Small-Bowel Tumors

Hatzaras, Ioannis; Palesty, J. Alexander; Abir, Farshad; Sullivan, Paul D.; Kozol, Robert A.; Dudrick, Stanley J.; Longo, Walter E.

doi:10.1001/archsurg.142.3.229

Cited by 190 publications

(62 citation statements)

References 24 publications

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“…The main location of the SBT reported in the literature is the ileum [3,4]. On the contrary, in our series, the lesions were almost exclusively located in jejunum.…”

Section: Discussioncontrasting

confidence: 81%

“…As reported in the literature [2,3,25], the patients were predominantly male and old, although without statistical significance. Forms of presentation were the usual ones: overt gastrointestinal bleeding and/or anemia, abdominal pain, and occlusive symptoms.…”

Section: Discussionmentioning

confidence: 68%

“…Their annual incidence is about 0.5-1.5/100,000 in males and 0.2-1.0/ 100,000 in females and fewer than 2,500 cases of small bowel cancer are diagnosed annually in the USA [2]. In regional epidemiological studies, their incidence has increased in the last decades [3].…”

Section: Background and Aimsmentioning

confidence: 99%

“…These tumors are preferentially located, by decreasing order, in the ileum, duodenum, and jejunum [3,4].…”

Section: Background and Aimsmentioning

confidence: 99%

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Double-Balloon Enteroscopy and Small Bowel Tumors: A South-European Single-Center Experience

et al. 2008

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Small bowel tumors are rare, accounting for 1-2% of all gastrointestinal neoplasms. We sought to determine the diagnostic and therapeutic impact of double-balloon enteroscopy (DBE) in patients with small bowel tumors. Between January 2005 and March 2008, 78 patients underwent 96 DBE. All nine patients (seven males; mean age 68 +/- 11.3 years) with small bowel tumors were retrospectively reviewed. Clinical presentation was: mid-gastrointestinal bleeding or iron-deficient anemia (55.6%); abdominal pain (22.2%); nausea/vomiting and abdominal distension (22.2%). Five patients had abnormal findings in previous capsule endoscopy and four in previous radiologic examinations. Route of insertion was exclusively oral and abnormal lesions were detected in all patients (jejunum 8; ileum 1). Biopsies were taken in seven patients and provided definitive histological diagnosis in all except one. There were no complications of DBE. Surgical resection took place in eight patients. Final histologic diagnosis were: primary carcinoma (33.3%), gastrointestinal stromal tumor (GIST) (33.3%), malignant lymphoma (22.2%), and carcinoid tumor (11.1%). Mean follow-up time was 15.4 +/- 12.7 months (range 2-34 months). Six patients were submitted to chemotherapy. Two patients died. Small bowel tumors are common in patients submitted to DBE. Given its safety and diagnostic capabilities, DBE should be considered the gold-standard method in the study of these neoplasms.

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“…The main location of the SBT reported in the literature is the ileum [3,4]. On the contrary, in our series, the lesions were almost exclusively located in jejunum.…”

Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 68%

Section: Background and Aimsmentioning

confidence: 99%

“…These tumors are preferentially located, by decreasing order, in the ileum, duodenum, and jejunum [3,4].…”

Section: Background and Aimsmentioning

confidence: 99%

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Double-Balloon Enteroscopy and Small Bowel Tumors: A South-European Single-Center Experience

et al. 2008

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“…Small-intestinal carcinoids (SIC) are the most common small-bowel malignancies, representing 31-41% of all small-bowel neoplasms (DiSario et al 1994, Lepage et al 2006, Hatzaras et al 2007, Bilimoria et al 2009). Although they may be diagnosed at any time, peak incidence occurs between the ages of 50 and 60 years.…”

Section: Introductionmentioning

confidence: 99%

The risk of metachronous cancers in patients with small-intestinal carcinoid tumors: a US population-based study

Amin¹,

Warner²,

Itzkowitz³

et al. 2012

Endocrine-Related Cancer

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Small-intestinal carcinoids (SIC) are the most common small-bowel malignancies. We sought to determine the risk of developing SIC before and after other primary malignancies (PM) and the prognosis of patients with SIC, with and without another PM. We used the Surveillance, Epidemiology, and End Results database to identify patients diagnosed with SICs between 1973 and 2007. Multiple primary-standardized incidence ratios were calculated as an approximation of relative risk (RR) to explore the association of SICs with metachronous malignancies. Survival analysis was performed using Kaplan-Meier methods and Cox proportional-hazard models. Among 8331 patients with SICs, 2424 (29%) had another PM at some time. The most common sites were prostate (26.2%), breast (14.3%), colon (9.1%), lung/bronchus (6.3%), and bladder (5.3%). Overall, 67% of patients had a PM diagnosed before SIC (pre-SIC), 33% after SIC (post-SIC), and 8% had a PM both before and after SIC. Among the pre-SIC group, the risk of future SIC was increased after cancers of the small bowel (RR 11.86 (95% CI: 6

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