Small bowel perforation without tumor recurrence after radiotherapy for cervical carcinoma: Report of seven cases

Yamashita, Hideomi; Nakagawa, Keiichi; Tago, Masao; Igaki, Hiroshi; Shiraishi, Kenshirou; Nakamura, Naoki; Sasano, Nakashi; Yamakawa, Sen; Ohtomo, Kuni

doi:10.1111/j.1447-0756.2006.00382.x

Cited by 11 publications

(11 citation statements)

References 17 publications

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“…Additionally, the number of perforations was also just one in all seven cases. In the study (8), biological effective dose (BED) around the perforation site was much higher than that of TD50/5 in all six cases (one case was unavailable for 3D dose distribution of ICRT). It was suspected that small bowel perforation was likely caused by a hot spot in the irradiated volume.…”

Section: Discussionmentioning

confidence: 99%

“…The prone position may be of promise in reducing the hot spot dose of the bladder, but this position is too difficult to maintain during ICRT in a clinical situation. In our previous report (8), a database consisting of 95 Japanese women with FIGO stage 0 -IVA cervix cancer treated with combined external beam radiotherapy plus ICRT between 1991 and 2004 contained seven patients (7.4%) with small bowel perforation. The perforation site was the ileum in all seven cases.…”

Section: Discussionmentioning

confidence: 99%

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Correlation Between Bladder Volume and Irradiated Dose of Small Bowel in CT-based Planning of Intracavitary Brachytherapy for Cervical Cancer

Yamashita

Nakagawa

Okuma

et al. 2012

Japanese Journal of Clinical Oncology

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Objective: To quantify the effect of bladder volume on the dose distribution of intracavitary brachytherapy in computed tomography-based treatment planning for cervical cancer. Methods: Ten patients with cervical cancer were treated with high-dose rate radiation brachytherapy. For the three-dimensional analysis, pelvic computed tomographic scans were obtained from patients with indwelling catheters in place and from patients who received 50, 100, 150 and 200 cc injections of sterile water into their bladders ('200 cc' was defined as a full bladder). Additionally, scans were made in the prone position with the full bladder. Results: Bladder fullness significantly affected the dose to the small bowel and bladder. The median of maximal doses to the small bowel was significantly greater with an empty bladder in all factors of hot spot (480 vs. 256 cGy on D-2cc). Although dosimetry revealed lower doses for larger volumes of bladder (D-50 and V-25%), the median maximal dose to the bladder was significantly greater with a full bladder (420 vs. 775 cGy on D-2cc). The rectosigmoid doses were not affected by bladder distension (476 vs. 467 cGy on D-2cc). After changing to the prone position, the hot spot dose of small bowel did not change but that of the bladder significantly decreased, although this procedure was very difficult. Conclusions: An increase in bladder volume resulted in a significant reduction in the hot spot dose of the small bowel at the expense of an increase in that of the bladder without changing the dose distribution of the rectosigmoid.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Correlation Between Bladder Volume and Irradiated Dose of Small Bowel in CT-based Planning of Intracavitary Brachytherapy for Cervical Cancer

Yamashita

Nakagawa

Okuma

et al. 2012

Japanese Journal of Clinical Oncology

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“…The details of the treatment protocol have been previously reported (7)(8)(9). External beam cCRT energy was 10 MV.…”

Section: Radiotherapymentioning

confidence: 99%

Correlation Among Six Biologic Factors (p53, p21WAF1, MIB-1, EGFR, HER2, and Bcl-2) and Clinical Outcomes After Curative Chemoradiation Therapy in Squamous Cell Cervical Cancer

Yamashita

Murakami

Asari

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…[14][15][16][17] Accurate identification of the lesions involved, including peritoneal dissemination and the setting of the radiation field, is important to avoid recurrence after chemo-radiotherapy. Reported serious adverse effects of chemoradiotherapy for gastric cancer include gastrointestinal perforation and bleeding, [18][19][20] which did not occur in this study. In addition, no cardiac, hepatic or renal dysfunction developed during the follow-up period.…”

Section: Discussionmentioning

confidence: 79%

Usefulness of chemoradiotherapy for inoperable gastric cancer

Taki

Hoya

Watanabe

et al. 2017

annals

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INTRODUCTION Radiotherapy is not commonly used for the treatment of gastric cancer in Japan, where surgery is the standard local treatment. We report the results of chemoradiotherapy in patients with advanced or recurrent gastric cancer which was deemed difficult to treat surgically. METHODS Twenty-one patients with gastric cancer (including sixteen with advanced/recurrent gastric cancer and five with poor general condition) underwent chemo-radiotherapy, for whom the therapeutic efficacy, toxicity and survival period were analysed. RESULTS The tumour response to chemoradiotherapy was categorised as complete, partial, stable or progressive in 5, 9, 3, and 4 patients, respectively, with an overall response rate of 67%. No serious complications such as gastrointestinal perforation or bleeding occurred, and no cardiac, hepatic or renal dysfunction developed during the follow-up period. The mean survival time was 19.8 months (range, 3-51 months). One patient died of another disease, 18 died of primary cancer and the cause of death was unknown in 2 patients. CONCLUSIONS Chemoradiotherapy appears to be an effective treatment for localised gastric cancer without distant metastases, but further studies are needed to determine the indications for chemoradiotherapy and late adverse effects, as well as the chemotherapy regimens to be used.

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Small bowel perforation without tumor recurrence after radiotherapy for cervical carcinoma: Report of seven cases

Abstract: The presenting complaints of patients with bowel perforation following radiotherapy vary, and signs of peritonitis may be absent. Emergency physicians must be alert for these complications in patients who have been treated with radiotherapy.

Cited by 11 publications

References 17 publications

Correlation Between Bladder Volume and Irradiated Dose of Small Bowel in CT-based Planning of Intracavitary Brachytherapy for Cervical Cancer

Correlation Between Bladder Volume and Irradiated Dose of Small Bowel in CT-based Planning of Intracavitary Brachytherapy for Cervical Cancer

Correlation Among Six Biologic Factors (p53, p21WAF1, MIB-1, EGFR, HER2, and Bcl-2) and Clinical Outcomes After Curative Chemoradiation Therapy in Squamous Cell Cervical Cancer

Usefulness of chemoradiotherapy for inoperable gastric cancer

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