Small Bowel PCI Score as a Prognostic Factor of Ovarian Cancer Patients Undergoing Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), a Retrospective Analysis of 130 Patients

Iavazzo, Christos; Fotiou, Alexandros; Psomiadou, Victoria; Lekka, Sofia; Katsanos, Dimitrios; Spiliotis, John

doi:10.1007/s13193-021-01304-w

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…To achieve complete resection, an extended multivisceral and/or peritoneal resection is usually needed. On the other hand, the degree of small bowel involvement is insistently considered to be a limiting factor to radically eradicate macroscopic tumor burden 8 , 20 – 22 . The terminal ileum, as a special part of the small bowel with its own features of anatomical fixity and limited peristaltic movements, is frequently resected in cytoreductive procedures.…”

Section: Discussionmentioning

confidence: 99%

Neglected prognostic importance of ileal resection in patients with peritoneal metastasis

Bişgin

Sökmen

Manoğlu

et al. 2022

Sci Rep

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We aimed to determine the prognostic role of ileal resection on postoperative complications and the final oncological results of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) treatment in patients with peritoneal metastasis (PM). Patients with PM who underwent CRS and HIPEC between 2007 and 2020 were analyzed retrospectively. Ileal resection was defined as the resection of the ileum at 100 cm or below. Patients were divided into ileal-resection and non-ileal resection groups. Besides clinico-pathological variables, peritoneal cancer index (PCI), completeness of cytoreduction (CC-0-1-2), (neo)adjuvant chemotherapy, operative time, need for surgical intensive care unit, and usage of blood products were all evaluated. The data of 664 patients was analyzed. Ileal resection was performed in 346(52.1%) patients. The median follow-up period was 27 months. The ileal resection group had significantly lower 3-and 5-year survival rates (55% and 43% vs. 69% and 52, p = .005, respectively). High PCI score (p < .001), more CC-1-2 cytoreductions (p < .001), more anastomoses (p < .001), prolonged operative time (p < .001), more ostomy creation (p = .001), increased morbidity (p < .001), and more infectious complications (p < .001) were all significantly associated with ileal resection. The loss of ileal function has a potential prognostic role in increased post-operative complications and worsened overall survival in patients with PMs.

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Section: Discussionmentioning

confidence: 99%

Neglected prognostic importance of ileal resection in patients with peritoneal metastasis

Bişgin

Sökmen

Manoğlu

et al. 2022

Sci Rep

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“…Evaluation of the prognostic value of small bowel PCI in patients with advanced epithelial OC undergoing cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) shows that both small bowel PCI and cytoreduction completeness are independent prognostic factors of overall survival, while age and timing of HIPEC have not been identified as independent prognostic factors [73].…”

Section: Peritoneal Cancer Index (Pci)mentioning

confidence: 99%

Imaging of Peritoneal Carcinomatosis in Advanced Ovarian Cancer: CT, MRI, Radiomic Features and Resectability Criteria

Miceli,

Gennarini,

Tomao

et al. 2023

Cancers

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PC represents the most striking picture of the loco-regional spread of ovarian cancer, configuring stage III. In the last few years, many papers have evaluated the role of imaging and therapeutic management in patients with ovarian cancer and PC. This paper summed up the literature on traditional approaches to the imaging of peritoneal carcinomatosis in advanced ovarian cancer, presenting classification systems, most frequent patterns, routes of spread and sites that are difficult to identify. The role of imaging in diagnosis was investigated, with particular attention to the reported sensitivity and specificity data—computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT (PET-CT)—and to the peritoneal cancer index (PCI). In addition, we explored the therapeutic possibilities and radiomics applications that can impact management of patients with ovarian cancer. Careful staging is mandatory, and patient selection is one of the most important factors influencing complete cytoreduction (CCR) outcome: an accurate pre-operative imaging may allow selection of patients that may benefit most from primary cytoreductive surgery.

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Antineoplastics

2021

Reactions Weekly

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Acute renal failure: 2 case reportsIn a retrospective study of 130 patients (aged 28-73 years) with ovarian cancer treated between 2005 and 2019, 2 women [ages at reaction onset not stated] were described, who developed acute renal failure following chemotherapy with bevacizumab, carboplatin, cisplatin and paclitaxel for ovarian cancer with peritoneal metastasis.The women, who had ovarian cancer with peritoneal metastasis, were scheduled to undergo debulking surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for recurrent ovarian cancer (n=1) and intermediate cytoreductive surgery combined with HIPEC after unspecified neoadjuvant chemotherapy (n=1). They underwent laparotomy, followed by surgery. Then, they underwent closed abdomen technique HIPEC with cisplatin 100 mg/m 2 , paclitaxel 175 mg/m2 carboplatin and bevacizumab [not all dosages stated] was in the abdominal cavity heated to 40°C for 90 min. They developed complications in the form of acute renal failure due to toxicity of HIPEC [times to reactions onsets and outcomes not stated].

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Small Bowel PCI Score as a Prognostic Factor of Ovarian Cancer Patients Undergoing Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), a Retrospective Analysis of 130 Patients

Cited by 4 publications

References 38 publications

Neglected prognostic importance of ileal resection in patients with peritoneal metastasis

Neglected prognostic importance of ileal resection in patients with peritoneal metastasis

Imaging of Peritoneal Carcinomatosis in Advanced Ovarian Cancer: CT, MRI, Radiomic Features and Resectability Criteria

Antineoplastics

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