Small Bowel Neuroendocrine Tumors

Tran, Catherine; Sherman, Scott K.; Howe, James R.

doi:10.1016/j.cpsurg.2020.100823

Cited by 18 publications

(33 citation statements)

References 130 publications

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“…The surgical intervention was performed in our case and the small intestine (duodenum, jejunum, and ileum) was carefully explored by palpation to identify small NEN or GIST (those identified by imaging methods or those not identified by them). Careful exploration of the small intestine is a very important part of the intervention because small tumors in the small intestine or metastases in the mesentery can escape from imaging detection, but can be identified directly [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Duodenal Ampulla Neuroendocrine Tumor with GISTs of the Proximal Jejunum: A Case Report

Nagy

Neag

Drasovean

et al. 2022

IJMS

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Neuroendocrine tumors (NEN) are a type of heterogenous, slow-growing tumors, that only in about half of the cases can be found in the gastrointestinal tract. Half of these is in the small intestine. The ampullary NENs are rare, accounting for less than 1% of gastroenteropancreatic NENs. Gastrointestinal stromal tumors (GIST) are a more common type of tumors of the gastrointestinal tract that consist of pacemaker cells. The occurrence of both tumors simultaneously is rare, but in patients with neurofibromatosis type 1, the co-existence of NEN and GIST is more often. Here we report a case of simultaneous occurrence of a well-differentiated NEN and a GIST in a patient without neurofibromatosis. Also, we provide a short review of the current knowledge and treatment strategies regarding these tumors.

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Section: Discussionmentioning

confidence: 99%

Duodenal Ampulla Neuroendocrine Tumor with GISTs of the Proximal Jejunum: A Case Report

Nagy

Neag

Drasovean

et al. 2022

IJMS

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“…A primeira descrição de um NET foi em 1867, quando Theodor Langhans relatou um tumor polipóide, do intestino delgado, que se apresentava de forma pouco diferenciada histologicamente, mas sem evidência de invasão local. Posteriormente, em 1888, Otto Lubarsch descreveu pólipos semelhantes em região ileal, seguido por William Ranson, que relatou o primeiro caso de síndrome carcinóide em uma mulher, com dor abdominal, diarréia, espirros e pólipos ileais, em 1890 (TRAN, 2020).…”

Section: Históricounclassified

“…Apesar destas descobertas, o uso do termo "carcinóide", como sinônimo de "carcinomalike", para descrever os tumores que aparentavam malignidade histologicamente, mas que apresentavam comportamento benigno, ocorreu apenas em 1907, em uma publicação de Siegfried Oberndorfer. Em 1963, Williams and Sandler "aumentaram" a abrangência do termo carcinóide, visando incluir outros tumores funcionais que apresentassem achados clínicos e bioquímicos semelhantes, passando a categorizar os tumores carcinóides por meio de sua origem embriológica (TRAN, 2020). A World Health Organization (WHO) manteve essa classificação por muitos anos, mas ao longo do tempo, foi ficando evidente que a diversidade desses tumores não estava adequadamente representada por essa nomenclatura.…”

Section: Históricounclassified

“…Além disso, a imensa maioria dos pacientes não apresentavam a síndrome carcinóide própriamente dita. Nesse sentido, (Capella et al 1995) recomendou a troca da nomenclatura "carcinóide" por "tumores neuro-endócrinos" para nomear tumores derivados das células neuroendócrinas e que são definidos pelas substâncias por eles secretadas (TRAN, 2020).…”

Section: Históricounclassified

“…Quando o local do tumor primário é desconhecido, especialmente durante análises de biópsias de metástases hepáticas, o uso de marcadores adicionais na imunohistoquímica pode ser útil. A coloração homeobox 2 (CDX2) do tipo caudal positiva sugere um NET de intestino médio, enquanto a coloração do gene box pareado positivo 6 (PAX6) e/ou proteína de ligação ao gene da insulina (ISL1) sugere um primário pancreático (TRAN et al, 2020). Tabela 6.2 Classificação dos tumores de órgãos endócrinos, segundo a WHO 2017.…”

Section: Imagemunclassified

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Tumor Neuroendócrino Não Funcionante De Intestino Delgado

COSTA¹,

NARDELLI²,

ESPASANDIN³

2022

Gastroenterologia E Hepatologia - Edição I

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Cytology as the guiding light: Prompt cytomorphologic diagnosis of cystic metastases from a jejunal neuroendocrine tumor masquerading as hepatic abscesses

Tom

Singh

Gupta

et al. 2023

Diagnostic Cytopathology

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Hepatic cystic lesions are commonly seen in radiology and can occur due to infective or neoplastic causes. It is imperative to determine the precise nature of these hepatic cysts owing to significant therapeutic and prognostic differences. Hepatic metastases from gastrointestinal neuroendocrine tumors (NETs) mostly present as solid hypervascular lesions. Cystic presentation of the metastatic NETs is extremely rare. A 64-year-old woman presented with an abdominal lump of 3 months duration and high-grade fever from the last 2 days. An ultrasound abdomen revealed multiple hypoechoic liver lesions suggestive of liver abscesses. An ultrasound-guided fineneedle aspiration (FNA) from the cystic liver lesions revealed a NET confirmed by immunocytochemistry. The Ki-67 index was 5%; hence, a final diagnosis of metastatic NET, grade 2, was given with advice to work up for localizing the primary tumor. Subsequently, a contrast-enhanced computerized tomography of the abdomen revealed a polypoidal lesion in the proximal jejunum, which showed intense expression on the whole-body DOTANOC scan (SUVmax-76.5), indicating it to be the likely primary tumor along with somatostatin receptor-expressing multiple lymph nodes and hypodense liver lesions. Thus, a final diagnosis of a jejunal NET with abdominal lymph node and liver metastases was made. The present report highlights the importance of FNA as a reliable modality in diagnosing metastatic NETs presenting as unusual cystic hepatic metastases masquerading as liver abscesses. Additionally, the cell block helps confirm the cytologic diagnosis and enables upfront tumor grading, thereby helping in prognostication and therapeutic decision-making.

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Small Bowel Neuroendocrine Tumors

Cited by 18 publications

References 130 publications

Duodenal Ampulla Neuroendocrine Tumor with GISTs of the Proximal Jejunum: A Case Report

Duodenal Ampulla Neuroendocrine Tumor with GISTs of the Proximal Jejunum: A Case Report

Tumor Neuroendócrino Não Funcionante De Intestino Delgado

Cytology as the guiding light: Prompt cytomorphologic diagnosis of cystic metastases from a jejunal neuroendocrine tumor masquerading as hepatic abscesses

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