Small bowel metastasis from pulmonary rhabdomyosarcoma causing intussusception: a case report

Sun, Ke‐kang; Shen, Xiaojun

doi:10.1186/s12876-019-0990-4

Cited by 6 publications

(3 citation statements)

References 18 publications

(14 reference statements)

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“…According to our study, bone was the most common involved sites in metastatic RMS, and the lung ranked second. One patient (case 1) showed liver metastases in our study, and breast (14,15) and small bowel metastasis (16) were seen in previous studies.…”

Section: Discussionsupporting

confidence: 82%

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Liu

Zhao

et al. 2020

Front. Med.

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Background: The role of [ 18 F] fluoro-deoxyglucose [[ 18 F] FDG] positron emission tomography (PET)/computed tomography (CT) in pediatric rhabdomyosarcoma (RMS) is not well-established. This manuscript explores the role of staging and therapy response evaluation of PET/CT in a series of patients with RMS. Methods: Thirteen consecutive patients with pathologically proven RMS underwent baseline PET/CT scan and a second PET/CT for evaluation of therapy response. Maximum standardized uptake value (SUV max), mean standardized uptake value (SUV mean), highest standardized uptake peak value (SUV peak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained from baseline PET/CT and were used as potential predictors for evaluation of metabolic treatment response. Results: On baseline PET/CT, most RMSs are located in the pelvic cavity, and upper arms ranked second. The primary lesions were large and showed invasion to the surrounding tissues. Lymph node metastases were seen in eight patients, and eight patients showed distant metastasis to the lung, liver, and bone. The median SUV max , SUV mean , and SUV peak of primary sites were 7.1, 4.0, and 5.9, respectively. The median MTV and TLG were 196.6 cm 3 and 780.2, respectively. After therapy, six patients received complete metabolic response (CMR) and non-CMR occurred in seven patients on the second PET/CT. SUV max , SUV peak , MTV, and TLG in patients with CMR were significantly lower than those in patients with non-CMR. Conclusions: Primary sites and metastatic lesions of RMS demonstrate increased glycolytic activity, which may allow them to be imaged using [ 18 F] FDG PET/CT. Metabolic parameters derived from the baseline PET/CT have potential value for predicting CMR to therapy in pediatric RMS.

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Section: Discussionsupporting

confidence: 82%

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Liu

Zhao

et al. 2020

Front. Med.

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“…In addition, a study illustrated that metabolic parameters obtained from baseline PET/CT were potential to select patients sensitive to treatment ( 31 ). Features of patients including unfavorable sites of the primary tumor, older patient age at initial presentation, the alveolar subtype, and regional lymph node involvement are considered to be poor prognostic factors for RMS ( 5 , 32 ). Unfavorable sites include the prostate and bladder, cranial parameningeal sites, extremities, trunk, retroperitoneum, and other sites ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal alveolar rhabdomyosarcoma intruding into spinal canal: A case report and literature review

Zhang

Huang

et al. 2022

Front. Med.

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BackgroundRhabdomyosarcoma (RMS) is the most frequent soft sarcoma in children and adolescents. Alveolar rhabdomyosarcoma (ARMS) is a relatively rare subtype that is characterized by aggressive behavior and an unsatisfactory prognosis. An ARMS can arise anywhere but most commonly occurs at extremity sites with a very small fraction in the retroperitoneum. The utility of 2-Deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) positron emission tomography combined with computed tomography (PET/CT) remains to be established in ARMS.Case ReportA 3-year-old female child was accidentally found with a large left upper abdominal mass for a day. CT examination indicated a huge soft tissue mass in the left retroperitoneum extending superiorly to the level of the left hilus renalis and inferiorly to the left acetabulum in the pelvic cavity, with intrusion into the lumbar foramens. 18F-FDG PET/CT found a mass in the left retroperitoneum from the level of T12 to the left acetabulum, with the maximum standardized uptake value (SUVmax) of about 7.0, and a CT value of about 39 HU, invading the left L3-5 intervertebral foramina and protruding into the spinal canal, with unclear boundary with the spinal cord. Retroperitoneal tumor resection and the repair operation of vascular exploration were performed. An ARMS was confirmed by postoperative biopsy, immunohistochemical staining, and genetic detection with the rupture of the fork head in rhabdomyosarcoma (FKHR). The patient received chemotherapy and was in a good condition with no recurrence and obvious complications.ConclusionRetroperitoneal ARMS is rare and indicates a poor outcome with the potential to involve vital organs and intrude into the spinal canal. Accurate diagnosis and staging using PET/CT would contribute to better risk stratifications and appropriate treatment individually.

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“…Rowe et al [52] x Ruffolo et al [48] x Sabel et al [18] x Shibata et al [17] x Sondenaa et al [31] x Sun et al [7] x…”

Section: Oldfield Et Al 36 Xmentioning

confidence: 99%

Small Bowel Intussusception Secondary to Metastatic Spindle Cell Sarcoma: A Case Report and Review of the Literature

Wong

Ayyad

et al. 2020

OAJOM

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Background: Intussusception is an uncommon diagnosis in adults. It is characterized by an abnormal luminal "lead point" that precipitates bowel invagination, resulting in obstructive symptoms that warrants further investigation. Both benign and malignant tumors have been reported to cause small bowel intussusception, with primary small bowel malignancies occurring more commonly. We present an unusual case of a middle-aged gentleman with small bowel intussusception and obstruction caused by a metastatic spindle cell sarcoma and a review of the available literature.Case Presentation: A 50-year-old male patient with a history of recurrent spindle cell sarcoma of the scalp treated 3 years prior presented with abdominal pain and bloating. Diagnostic workup revealed two segments of small bowel intussusception and obstruction as well as several lung nodules. The patient underwent exploratory laparotomy for resection and primary anastomosis of the intussuscepted segments of small bowel. Histologic analysis of the surgical specimens confirmed metastatic spindle cell sarcoma. After completion of full metastatic workup, patient was counseled on the diagnosis and offered palliative chemotherapy while awaiting results from tumor molecular profiling to guide future treatment and clinical trial options. Conclusion:Intussusception in the adult patient should be carefully evaluated, with a high suspicion for malignancy as the underlying cause, especially in those with a personal history of cancer.

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Small bowel metastasis from pulmonary rhabdomyosarcoma causing intussusception: a case report

Cited by 6 publications

References 18 publications

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Retroperitoneal alveolar rhabdomyosarcoma intruding into spinal canal: A case report and literature review

Small Bowel Intussusception Secondary to Metastatic Spindle Cell Sarcoma: A Case Report and Review of the Literature

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