Small bowel intussussception due to metastatic melanoma of unknown primary site. Case report

Stagnitti, F; Orsini, S; Martellucci, A; Tudisco, Antonella; Avallone, Marcello; Aiuti, F; Girolamo, Di; Stefanelli, Francesco; Angelis, Flavio De; Grazia, Carmen Di; Napoleoni, A; Nicodemi, S.; Cipriani, B; Ceci, Fabrizio; Mosillo, R; Corelli, Sergio; Casciaro, G; Spaziani, Erasmo

doi:10.11138/gchir/2014.35.9.246

Cited by 4 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No significant differences were observed between both groups with respect to the following baseline characteristics, patient age and sex, Child-Pugh class , proportions of patients positive for hepatitis C virus antibody. In our study 52.5%of the HCC lesions were medium-sized (5 cm) and 47.5% are large (5.1 To 7cm), this was not in agreement with Livraghi et al, 9 who studied 114 patients with HCC (with 126 focal HCC) and found that 80 tumors were medium and 46 were large. The liver biochemical profile in our study that is at one month after the end of sessions showed slight changes and after six months we found increase in transaminase as well as bilirubin levels above the pre-ablation level in 77% of patients.…”

Section: Resultscontrasting

confidence: 93%

“…Regarding the survival in our study , 12 months survival was recorded in 85% of patients of both groups. Our study was controversial with other studies conducted by Livraghi et al, 9 and Cheng et al 2 who follow up the survival of the patients for longer periods, this was due to the selection of the patients with medium or large size lesions which seemed to be difficult to follow up for longer period. In our study, no significant differences were observed between both groups with respect to the following baseline characteristics, patient age and sex , Child-Pugh class , proportions of patients positive for hepatitis C virus antibody and positive for hepatitis B surface antigen.…”

Section: Resultsmentioning

confidence: 55%

See 1 more Smart Citation

Combined Radiofrequency Ablation and Transarterial Chemoembolization in Treatment of Unresectable Primary Liver Cancer

Mohamed¹

2015

GHOA

View full text Add to dashboard Cite

Introduction: HCC is the fifth most common cancer worldwide. Surgical therapy, as a curative option, is indicated only in patients with single HCC without portal hypertension and preserved liver function. Hepatic resection of HCC in patients with cirrhosis is associated with significant peri-operative mortality and morbidity. Cirrhotic patients with non-respectable HCC have a poor prognosis influenced by hepatic reserve function and tumor staging. 1 Surgical resection is the standard of care because it has been shown to provide survival benefits, while systemic chemotherapy and radiotherapy are ineffective, Liver transplantation seems to be the choice for mono-focal HCC less than 5 cm in diameter and in selected cases of multifocal HCC, but may be limited by availability of donor organs and a long waiting time. 1 TACE has been shown to reduce systemic toxicity and increase local effects and thus improve therapeutic results. The core concept includes selective embolization of tumour-feeding arteries with a chemotherapeutic agent in an emulsion with iodized oil and subsequent embolization with a particulate agent, The chemotherapeutic regime varies considerably between centers, as does the choice of embolization agent including non-permanent embolic material such as absorbable gelatine powder or polyvinyl alcohol particles, gelatine-coated tri-acryl embospheres or biocompatible polyvinyl alcohol hydro-gels (bead block). Doxorubicin is the most commonly used agent. 2 Because blood flow promotes heat loss, and heat loss may reduce the effectiveness of RFA, a possible way to increase the ablation size of RFA thermal lesions would be to reduce or eliminate the heat loss that is mediated by tissue perfusion, Blood flow to hepatocellular carcinoma lesions can be substantially reduced by the arterial embolization effect of TACE treatment. Moreover, TACE has a strong antitumor effect on hepatocellular carcinoma lesions. However, both TACE and RFA have some well-known limitations. In particular, neither results in adequate control of hepatocellular carcinoma tumors larger than 3cm. Consequently, multimodal combined treatment is an appealing alternative, especially for patients with large hepatocellular carcinoma. 2Background: In this study, the outcome of the combination of RFA with TACE was retrospectively evaluated and the effectiveness of this combination treatment on large unresectable primary liver cancer. We carried out a prospective, randomized controlled trial to assess the benefits of combined TACE-RFA for large unresectable hepato-cellular carcinoma. Method:In the present work, 20 patient with single unresectable HCC from Cairo between 35-50years will be investigated, Patients were randomized into two groups, Group (1), starting by radiofrequency ablation followed by TACE after 4weeks then follow up by TACE, Group (2), starting by chemo-embolization followed by sequential radiofrequency ablation after 2weeks from TACE

show abstract

Section: Resultscontrasting

confidence: 93%

Section: Resultsmentioning

confidence: 55%

Combined Radiofrequency Ablation and Transarterial Chemoembolization in Treatment of Unresectable Primary Liver Cancer

Mohamed¹

2015

GHOA

View full text Add to dashboard Cite

show abstract

“…Twenty four different cases of primary malignant melanoma have been reported in the literature (1,2,6,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)46) according to the criteria proposed by Sacks et al but in some of these cases the follow-up is not according to these criteria for primary lesion. All the cases described in the literature show a wide range of patient's age with the highest prevalence above the age of 40 years.…”

Section: Discussionmentioning

confidence: 99%

Primary small bowel melanoma. A case report and a review of the literature

Spiridakis¹

2015

GCHIR

View full text Add to dashboard Cite

show abstract

“…Surgical exploration with bowel resection remains the standard of care, especially for patients with limited spread of the disease. However, surgery is not curative and it should be considered as a good mean of palliation with a chance of improving prognosis when free surgical margins can be achieved [1,9]. Postoperative chemotherapy is sometimes administered as further palliative treatment although evidence of its effectiveness is currently lacking [7].…”

Section: Discussionmentioning

confidence: 99%

Video Capsule Endoscopy is useful in the Management of Metastatic Malignant Melanoma?

Saglio¹

2015

GHOA

View full text Add to dashboard Cite

The incidence of melanoma has been increasing over the years. Mortality and morbidity remains high despite new therapies. Dissemination occurs primarily by the lymphatic route and than by hematogenous route. Gastrointestinal metastases do occur, but they are mainly intraluminal mucosal melanomas. We report a case of a man of 52 years old with a history of respected cutaneous melanoma who presented with rectal bleeding followed by recurrent episodes of melena, weight loss and severe anemia. Esophagogastroduodenoscopy and colonoscopy were performed without detecting any alteration except for the presence of a chronic atrophic gastritis, so a video capsule endoscopy was performed which showed, in the early jejunum, a substenosis from melanoma metastases associated with satellite lesions of whole jejunum. The patient was operated after being subjected to a computed tomography for staging the disease, but died after three months for the spread of disease. Since the melanoma incidence is rising, similar cases may present in the near future. This emphasizes the importance of a comprehensive study of the entire gastrointestinal tract endoscopy, highlighting the role of video capsule endoscopy as easy, noninvasive, and effective diagnostic procedures to carefully study the small bowel.

show abstract

Small bowel intussussception due to metastatic melanoma of unknown primary site. Case report

Cited by 4 publications

References 9 publications

Combined Radiofrequency Ablation and Transarterial Chemoembolization in Treatment of Unresectable Primary Liver Cancer

Combined Radiofrequency Ablation and Transarterial Chemoembolization in Treatment of Unresectable Primary Liver Cancer

Primary small bowel melanoma. A case report and a review of the literature

Video Capsule Endoscopy is useful in the Management of Metastatic Malignant Melanoma?

Contact Info

Product

Resources

About