Small-Bowel Changes in Dermatitis Herpetiformis

Tongeren, J. H. M. Van; Staak, W.J.B.M. van de; Schillings, P.H.M.

doi:10.1016/s0140-6736(67)91862-4

Cited by 37 publications

(11 citation statements)

References 5 publications

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“…Its incidence is, however, extremely low in patients presenting to dermatologists with eczema or psoriasis and we ourselves have only found it twice in over 200 such patients . The jejunal mucosa has now been examined in patients with eczema (Shuster and Marks, 1965), i^"thyosis vulgaris, Brocq's ichthysoiform erythroderma, acrodermatitis enteropathica (Fry, McMinn, and Shuster, 1966), psoriasis (Shuster, Watson, and Marks, 1967), rosacea (Watson, Paton, and Murray, 1965;Marks, Beard, Clark, Kwok, and Robertson, 1967), pemphigoid (Marks and Shuster, 1969), subcorneal pustular dermatosis (Fry, Keir, McMinn, Cowan, and Hoffbrand, 1967;Marks and Shuster, 1970), and dermatitis herpetiformis (Marks, Shuster, and Watson, 1966;van Tongeren, van der Staak, and Schillings, 1967;Fraser, Murray, and Alexander, 1967;Fry et al, 1967;Verbov and Barkhan, 1967;Marks, Whittle, Beard, Robertson, and Gold, 1968;Bendl and Williams, 1968).…”

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confidence: 99%

Small-intestinal mucosal abnormalities in various skin diseases fact or fancy?

Marks¹,

Shuster²

1970

Gut

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SUMMARY Two-thirds of patients with dermatitis herpetiformis have been found to have a flat or convoluted mucosa but no special association has been found in the other dermatoses studied with structural alterations in the small bowel mucosa. The frequency distribution of the predominant and individual small intestinal mucosal features is the same in the patients in the present series with eczema, psoriasis, and rosacea as in the local control population. Apredominantly convoluted mucosa has been found in the upper small intestine in 8 %of these patients and in 8 % of subjects without a rash. The presence of convolutions in patients with these dermatoses is merely a reflection of the incidence in the normal population of Newcastle upon Tyne. Different findings in the same skin disease in different parts of the country are explicable on the basis of variations in the nornmal mucosa between one geographical region and another.The increased incidence of a convoluted mucosa in the north east of England requires further study to determine whether it is indicative of an increased incidence of the coeliac syndrome in the region, or whether it results from a minor population difference or a local peculiarity of diet.

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confidence: 99%

Small-intestinal mucosal abnormalities in various skin diseases fact or fancy?

Marks¹,

Shuster²

1970

Gut

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“…One patient appears to have been relieved of both his malabsorption syndrome and skin disease by a gluten-free diet, as was one patient of Van Tongeren et al (1967), and we are investigating the effect of a gluten-free diet on many of the other patients in this series. In view of the many patients with abnormally low serum folate and vitamin B12 levels and some with megaloblastic changes in the marrow we are now giving our patients folic acid and vitamin B12 supplements when this measure is indicated.…”

Section: Discussionmentioning

confidence: 97%

“…The occurrence of jejunal mucosal abnormalities in dermatitis herpetiformis was first reported by Marks, Shuster, and Watson (1966) and Van Tongeren, Van der Staak, and Schillings (1967). More recently two other studies of small-bowel structure and function have been published (Fry, Keir, McMinn, Cowan, and Hoffbrand, 1967;Fraser, Murray, and Alexander, 1967).…”

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confidence: 88%

Small-bowel abnormalities in dermatitis herpetiformis.

Marks¹,

Whittle²,

Beard³

et al. 1968

BMJ

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“…The association of gluten-sensitive villous atrophy and DH is now well established (1)(2)(3)(4)(5)(6). It remains to be demonstrated, however, that the intestinal lesion of DH is identical to or different from that found in GSE and that the pathophysiology of the intestinal lesion of DH is or is not related to that of the skin lesion of DH.…”

Section: Discussionmentioning

confidence: 99%