Small Bowel Capsule Endoscopy Impacts Diagnosis and Management of Pediatric Inflammatory Bowel Disease: A Prospective Study

Gralnek, Ian M.; Cohen, Stanley A.; Ephrath, Hagit; Napier, Angela; Gobin, Tamara; Sherrod, Olga; Lewis, Jeffrey D.

doi:10.1007/s10620-011-1894-5

Cited by 55 publications

(39 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mohan et al (1) reported that 36 out of 42 patients (85.71%) had abnormal findings on OMOM capsule endoscopy in their study, among which 26 patients exhibited obscure gastrointestinal bleeding and a further 10 patients exhibited abdominal pain and/or diarrhea. However, the diagnostic yield in another study using the PillCam patency capsule was 77.78% (14/18) (19). In the present study, various types of lesion were detected in 54 out of 89 patients (60.67%), which was lower than the rates in previous studies.…”

Section: Discussioncontrasting

confidence: 86%

Diagnostic value of OMOM capsule endoscopy for small bowel diseases in adults

Zhang¹,

Shen²,

Guo³

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

Abstract. The present study aimed to determine the diagnostic yield of OMOM capsule endoscopy for small bowel diseases in adults. A total of 89 patients, including 45 cases of obscure abdominal pain, 22 of chronic diarrhea, 18 of obscure gastrointestinal bleeding and 4 of obscure anemia were enrolled in the present study. The transit time of the endoscopy capsule in the digestive tract was recorded and the testing results were analyzed. All detections were completed except for four capsule retentions and the completion rate was 95.51%. The average transit time of the endoscopy capsule in the esophagus, stomach and small intestine was 62.18±64.23 sec, 67.46±63.13 and 346.53±102.81 min, respectively. Of the 89 patients, 54 (60.67%) were found to have lesions, among which 19 had mucosal erosion (21.35%), 15 had anabrosis (16.85%), 9 were diagnosed with polyps (10.11%), 5 with angiodysplasia (5.62%); furthermore, tumors were identified in 5 patients (5.62%) and ancylostomiasis in 1 patient (1.12%). The results confirmed the feasibility and validity of OMOM capsule endoscopy for diagnosing small bowel diseases in adults.

show abstract

Section: Discussioncontrasting

confidence: 86%

Diagnostic value of OMOM capsule endoscopy for small bowel diseases in adults

Zhang¹,

Shen²,

Guo³

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…A large number of studies on small bowel lesions in CD using capsule endoscopy (CE) have clearly shown the superior diagnostic power of CE compared to other modalities [16, 17], as well as its usefulness in evaluation of disease activity [18, 19] and treatment selection [20, 21]. However, few studies have assessed UC small bowel lesions and none appear to have investigated the differences between these lesions in UC and CD.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Small Bowel Lesions Using Capsule Endoscopy in Ulcerative Colitis and Crohn’s Disease: A Single-Center Retrospective Analysis

et al. 2018

View full text Add to dashboard Cite

Background: Capsule endoscopy (CE) has allowed the characterization of small bowel lesions. However, small bowel lesions in ulcerative colitis (UC) have not been elucidated and no studies have compared between UC and Crohn’s disease (CD). Aim: The objective of this study was to investigate the small bowel lesions in UC, and to characterize UC lesions by comparison with CD. Methods: Subjects comprised 54 UC patients and 39 CD patients who underwent CE. We retrospectively investigated characteristics of small bowel lesions in UC. We also compared endoscopic findings and degree of inflammation between UC and CD. Results: The incidence of small bowel lesions in UC was 27.8%. The group with small bowel lesions exhibited higher endoscopic activity in the colon than without small bowel lesions (p = 0.002). Comparing small bowel lesions between UC and CD, significantly more ulcerative lesions, notched appearance, longitudinal tendency of lesions, and cobblestone appearance were seen in CD. The Lewis score was significantly higher in CD than UC in the second and third tertiles (205 ± 379 vs. 73 ± 223, p = 0.01; 358 ± 449 vs. 105 ± 333, p < 0.001). Conclusions: Small bowel lesions in UC were linked to colonic activity. UC and CD differ in terms of the morphology and distribution of small bowel lesions.

show abstract

“…Treatment changes brought about by CE include onset of a new therapy, medication changes or withdrawal, and surgery indication (41,76,77). At a practical level this impact on CD management will depend on the reason why CE was indicated.…”

Section: Impact Of Capsule Endoscopy On Crohn's Diseasementioning

confidence: 99%

“…This impact is particularly relevant at pediatric ages since CE reclassifies as CD 50 % of ulcerative colitis and IC cases, detects proximal lesions unnoticed by other techniques in 50 % of subjects, and changes therapeutic decisions for 78 % of patients (76).…”

Section: Impact Of Capsule Endoscopy On Crohn's Diseasementioning

confidence: 99%

Indications of capsule endoscopy in Crohn's disease

Luján-Sanchis

Sanchis-Artero

Suárez-Callol

et al. 2014

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

Capsule endoscopy currently plays a relevant role for Crohn's disease. This manuscript will discuss the current indications and practical uses of capsule endoscopy in this disease. It is a non-invasive technique that represents a significant advance in the endoscopic diagnosis of small bowel conditions. These circumstances, together with its diagnostic yield and excellent tolerability, make it considerably acceptable by both patients and physicians. This paper discusses the current evidence on the specific circumstances where capsule endoscopy may be indicated for three specific scenarios: Suspected Crohn's disease, indeterminate colitis, and established Crohn's disease, where it plays an extensive role. Furthermore, the impact and implications of capsule endoscopy results for follow-up are reviewed. These recommendations must be interpreted and applied in the setting of the integral, individual management of these patients. Understanding its appropriate use in daily clinical practice and an analysis of results may define endoscopic scoring systems to assess activity and mucosal healing in this condition. The present role of capsule endoscopy for Crohn's disease is subject to ongoing review, and appropriate usage uncovers novel applications likely to result in relevant changes for the future management of these patients.

show abstract

Small Bowel Capsule Endoscopy Impacts Diagnosis and Management of Pediatric Inflammatory Bowel Disease: A Prospective Study

Cited by 55 publications

References 23 publications

Diagnostic value of OMOM capsule endoscopy for small bowel diseases in adults

Diagnostic value of OMOM capsule endoscopy for small bowel diseases in adults

Comparison of Small Bowel Lesions Using Capsule Endoscopy in Ulcerative Colitis and Crohn’s Disease: A Single-Center Retrospective Analysis

Indications of capsule endoscopy in Crohn's disease

Contact Info

Product

Resources

About