Small bowel cancer: A 30-year review

Frost, Daniel B.; Mercado, Philip D.; Tyrell, Jon S.

doi:10.1007/bf02303567

Cited by 64 publications

(51 citation statements)

References 7 publications

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“…Although it remains to be defined, correlation between biallelic mutations and very young cancer might be probable. Studies have shown that both sporadic (20) and HNPCCassociated (13,16) SBCs are more common in males than females, with the latter showing a reported 3:1 ratio of males to females. In the present study, 60% of our enrolled patients were male, yielding a 3:2 ratio of males to females that is relatively consistent with the previous findings.…”

Section: Resultsmentioning

confidence: 99%

Germ Line Mutations of Mismatch Repair Genes in Hereditary Nonpolyposis Colorectal Cancer Patients with Small Bowel Cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study

Park

Kim

Hong

et al. 2006

Clinical Cancer Research

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Purpose:The aim of study was to determine the clinical characteristics and mutational profiles of the mismatch repair genes in hereditary nonpolyposis colorectal cancer (HNPCC) patients with small bowel cancer (SBC). Experimental Design: A questionnaire was mailed to 55 members of the International Society for Gastrointestinal Hereditary Tumours, requesting information regarding patients with HNPCCassociated SBC and germ line mismatch repair gene mutations. Results: The study population consisted of 85 HNPCC patients with identified mismatch repair gene mutations and SBCs. SBC was the first HNPCC-associated malignancy in 14 of 41 (34.1%) patients for whom a personal history of HNPCC-associated cancers was available. The study population harbored 69 different germ line mismatch repair gene mutations, including 31 mutations in MLH1, 34 in MSH2, 3 in MSH6, and 1in PMS2. We compared the distribution of the mismatch repair mutations in our study population with that in a control group, including all pathogenic mismatch repair mutations of the International Society for Gastrointestinal Hereditary Tumours database (excluding those in our study population). In patients with MSH2 mutations, patients with HNPCC-associated SBCs had fewer mutations in the MutL homologue interaction domain (2.9% versus 19.9%, P = 0.019) but an increased frequency of mutations in codons 626 to 733, a domain that has not previously been associated with a known function, versus the control group (26.5% versus 2.8%, P < 0.001).Conclusions: In HNPCC patients, SBC can be the first and only cancer and may develop as soon as the early teens.The distribution of MSH2 mutations found in patients with HNPCC-associated SBCs significantly differed from that found in the control group (P < 0.001).

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Section: Resultsmentioning

confidence: 99%

Germ Line Mutations of Mismatch Repair Genes in Hereditary Nonpolyposis Colorectal Cancer Patients with Small Bowel Cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study

Park

Kim

Hong

et al. 2006

Clinical Cancer Research

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“…Survival has not been shown to vary with subsite in small case series from single institutions (Zollinger, 1986;Cunningham et al, 1997;Ojha et al, 2000). Other studies (Ashley and Wells, 1988;Frost et al, 1994) have shown slightly more favourable prognosis for duodenal adenocarcinomas. However, hospital-based series are prone to selection bias.…”

Section: Discussionmentioning

confidence: 84%

Survival trends for small intestinal cancer in England and Wales, 1971–1990: national population-based study

Pashayan¹,

Lepage

Rachet

et al. 2006

Br J Cancer

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This population-based study examines prognostic factors and survival trends among adults (15 -99 years) diagnosed with small intestinal cancer in England and Wales during 1971 -1990 and followed up to 1995. During this period, the 1-and 5-year agestandardised relative survival rates for small intestinal cancers combined were 42% and 23%, respectively. Duodenal tumours, adenocarcinomas, men, patients with advanced age and the most deprived patients had the poorest prognosis. For all small bowel tumours combined, the excess risk of death fell significantly by 6 -9% every 4 years over the 20-year period (adjusted excess hazard ratio (EHR) 0.91 at 1 year after diagnosis, 0.94 at 5 years). For duodenal tumours, the EHR fell by about 14% (95% CI 5 -22%) every 4 years between 1979 and 1990, and a similar trend for jejunal tumours was of borderline significance. Further population-based investigations linking survival data to individual data on diagnostic methods and types of treatment are needed.

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“…Primary melanoma of the gastrointestinal tract is a rare tumour; involvement of the alimentary tract is usually secondary to metastatic spread from primary tumours [3]. In an autopsy study Avital et al showed that up to 60% of patients with melanoma have gastrointestinal involvement [4].…”

Section: Discussionmentioning

confidence: 99%

Primary Melanoma of the Right Colon Presenting With Gastrointestinal Bleeding

Gerald¹

2013

TOGASJ

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A 73 year old female presented with painless fresh rectal bleeding and anaemia. At colonoscopy, a large mass arising from the right colon was visualised and biopsied. Histological evaluation established a diagnosis of melanoma. Thorough clinical examination confirmed the presence of primary localised melanoma which was amenable to resection.At laparotomy, right hemicolectomy and lymphadenectomy were performed. Two years after her surgery, our patient is well without any evidence of disease recurrence.Primary melanoma of the colon is a very rare clinical entity and limited data are available regarding its pathogenesis, treatment and outcome. Primary surgical resection in localised disease appears to be the mainstay of treatment, although the role of adjuvant therapy is still to be established.

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Small bowel cancer: A 30-year review

Abstract: A correlation exists between the pathologic stage and the survival rate for adenocarcinoma. The most common recurrence pattern for adenocarcinoma was carcinomatosis, followed in frequency by abdominal wall recurrence. Leiomyosarcoma preferentially metastasizes to the liver.

Cited by 64 publications

References 7 publications

Germ Line Mutations of Mismatch Repair Genes in Hereditary Nonpolyposis Colorectal Cancer Patients with Small Bowel Cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study

Germ Line Mutations of Mismatch Repair Genes in Hereditary Nonpolyposis Colorectal Cancer Patients with Small Bowel Cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study

Survival trends for small intestinal cancer in England and Wales, 1971–1990: national population-based study

Primary Melanoma of the Right Colon Presenting With Gastrointestinal Bleeding

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