Small bowel adenocarcinoma and Crohn's disease: Any further ahead than 50 years ago?

Cahill, Caitlin; Gordon, Philip H.; Petrucci, Andrea; Boutros, Marylise

doi:10.3748/wjg.v20.i33.11486

Cited by 82 publications

(93 citation statements)

References 81 publications

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“…The most common site for GIST was the jejunum, for adenocarcinoma it was the duodenum, and for lymphoma it was the ileum. (Haselkorn et al, 2005;Bilimoria et al, 2009;Cahill et al, 2014;Anderson et al, 2015). In the present study, GIST was the most common histological subtype of small bowel cancer, followed by adenocarcinoma and lymphoma.…”

Section: Site Of Small Bowel Cancersupporting

confidence: 57%

Clinical, Radiologic, and Endoscopic Manifestations of Small Bowel Malignancies: a First Report from Thailand

Tangkittikasem

Boonyaarunnate²,

Aswakul³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 16 (18), 8613-8618 IntroductionSmall bowel cancer is a rare malignancy that accounts for only 2% of all gastrointestinal cancers (Paski, 2009;Pan et al, 2011). The incidence of malignant small intestine tumors, which ranges from 0.5-1.5/100,000 in men and 0.2-1.0/100,000 in women (Parkin et al., 1992), seems to be higher in North America and Europe than Asia (Haselkorn et al., 2005). Most cases of small bowel cancer are diagnosed late in the course of the disease because of its vague clinical presentations (e.g. abdominal pain and abdominal discomfort), and patients who present with obvious clinical manifestations such as gastrointestinal bleeding, intestinal obstruction, or ascites are almost always diagnosed with advanced stage cancer. The most common malignancy lesions are adenocarcinoma, neuroendocrine tumor (NET), sarcomas, and small bowel lymphoma. However, the incidence of small bowel cancer is increasing, particularly for carcinoid tumor (Islam, 2014). The small bowel is not a common location of metastatic cancers, although there are many case reports Based on radiology and endoscopy, this study revealed upper gastrointestinal bleeding, an intra-abdominal mass, and a sub-epithelial mass as common symptoms of GIST. Obstruction and ulcerating/circumferential masses were findicative of adenocarcinoma, as revealed by radiology and endoscopy, respectively. Finally, no specific symptoms were related to lymphoma.

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Section: Site Of Small Bowel Cancersupporting

confidence: 57%

Clinical, Radiologic, and Endoscopic Manifestations of Small Bowel Malignancies: a First Report from Thailand

Tangkittikasem

Boonyaarunnate²,

Aswakul³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…Many reports have documented that adenocarcinoma of the small bowel is a complication of CD [6] . As there are only a small number of cases of SRCC of the ileum in CD, this association has not been clearly established.…”

Section: Discussionmentioning

confidence: 99%

“…As there are only a small number of cases of SRCC of the ileum in CD, this association has not been clearly established. Patients with long-standing small bowel CD are thought to have an increased risk of small bowel carcinoma [6][7][8] . Many postulated risk factors surfaced as a result of observed trends across case reports such as previous strictureplasty and excluded/bypassed bowel segments [6,8] .…”

Section: Discussionmentioning

confidence: 99%

“…Patients with long-standing small bowel CD are thought to have an increased risk of small bowel carcinoma [6][7][8] . Many postulated risk factors surfaced as a result of observed trends across case reports such as previous strictureplasty and excluded/bypassed bowel segments [6,8] . The risk of developing small bowel carcinoma was also found to be much higher in patients whose disease was confined to the small bowel than in the patients with ileocolic CD [9] .…”

Section: Discussionmentioning

confidence: 99%

“…It is consensual that the risk of developing small bowel adenocarcinoma is greater in patients with CD than in the general population; however, the exact magnitude and the etiologic mechanism of the increased risk are difficult to determine [5][6][7][8] . Sometimes the patients who develop an adenocarcinoma are those with small bowel CD but most often there is a combination of those with both small and large bowel CD [5] .…”

Section: Introductionmentioning

confidence: 99%

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Signet Ring Cell Carcinoma, Ileal Crohn Disease or Both - A Case of Diagnostic Challenge

Carvalho¹,

Tavares²,

Goulart³

et al. 2017

GE Port J Gastroenterol

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ResumoO carcinoma de células em anel de sinete é uma forma rara de adenocarcinoma que afeta predominantemente o estômago. A forma primária do íleon é muito rara e apresenta mau prognóstico. Apresentamos um caso de doença de Crohn do íleon cuja forma de apresentação cursou com quadro oclusivo associado a adenocarcinoma de cé-lulas em anel de sinete do íleon. A doente apresentava história prévia de diarreia crónica e tinha história familiar de doença inflamatória. Foi submetida a ressecção cirúr-gica e os achados histopatológicos revelaram a presença de aspetos compatíveis com doença de Crohn do íleon e adenocarcinoma de células em anel de sinete. Foi proposta uma associação com esta forma rara de tumor e infla- Keywords Signet ring cell carcinoma · Crohn disease · Ileum AbstractSignet ring cell carcinoma is a rare form of adenocarcinoma that predominantly affects the stomach. Signet ring cell carcinoma originated from the ileum is extremely rare and the prognosis is poor. We present a case of small bowel obstruction with features suggesting Crohn disease of the ileum. The symptoms were chronic diarrhea and abdominal pain with a family history of inflammatory bowel disease. The patient underwent surgery and histopathology revealed both aspects of signet ring cell carcinoma and Crohn disease of the ileum. An association between long-standing inflammation and the development of this subtype of tumor has been proposed but there are no established surveillance guidelines for small bowel neoplasm in inflammatory bowel disease. 48 mação de longa duração, contudo, não existem recomendações estabelecidas de vigilância de neoplasia na doença inflamatória intestinal com atingimento ileal.

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Duodenal localization is a negative predictor of survival after small bowel adenocarcinoma resection: A population‐based, propensity score‐matched analysis

Wilhelm

Galata

Beutner

et al. 2017

Journal of Surgical Oncology

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Small bowel adenocarcinoma and Crohn's disease: Any further ahead than 50 years ago?

Cited by 82 publications

References 81 publications

Clinical, Radiologic, and Endoscopic Manifestations of Small Bowel Malignancies: a First Report from Thailand

Clinical, Radiologic, and Endoscopic Manifestations of Small Bowel Malignancies: a First Report from Thailand

Signet Ring Cell Carcinoma, Ileal Crohn Disease or Both - A Case of Diagnostic Challenge

Duodenal localization is a negative predictor of survival after small bowel adenocarcinoma resection: A population‐based, propensity score‐matched analysis

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