Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid

Fazlioğlu, Murat; Şentürk, Tunay; Kumbay, Ethem; Kaderli, Aysel Aydin; Yılmaz, Yusuf; Özdemi̇r, Bülent; Baran, İbrahim; Aydınlar, Ali

doi:10.1016/j.atherosclerosis.2008.04.014

Cited by 14 publications

(17 citation statements)

References 19 publications

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“…Cardiovascular clinical outcomes and extent of atherosclerotic plaques have been two major end points used in numerous studies in this field to date. After the early work of Allard and Goulet [29], which refuted an association between SUA levels and angiographically proven CAD severity, a number of subsequent investigations [30,31,32,33] suggested a positive independent association, while others did not [34,35,36]. Differences in studied populations, study protocols and methods to detect CAD (electron beam CT, coronary angiography) as well as lack of adjustment for inflammatory markers and other novel cardiovascular risk factors may in part account for discrepancies in the results of these studies.…”

Section: Discussionmentioning

confidence: 99%

Uric Acid and Pentraxin-3 Levels Are Independently Associated with Coronary Artery Disease Risk in Patients with Stage 2 and 3 Kidney Disease

Kanbay¹,

Ikizek²,

Solak³

et al. 2011

Am J Nephrol

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Background and Objectives: Cardiovascular disease is prevalent in chronic kidney disease (CKD). Uric acid is increased in subjects with CKD and has been linked with cardiovascular mortality in this population. However, no study has evaluated the relationship of uric acid with angiographically proven coronary artery disease (CAD) in this population. We therefore investigated the link between serum uric acid (SUA) levels and (i) extent of CAD assessed by the Gensini score and (ii) inflammatory parameters, including C-reactive protein (CRP) and pentraxin-3, in patients with mild-to-moderate CKD. Material and Methods: In an unselected population of 130 patients with estimated glomerular filtration rate (eGFR) between 90 and 30 ml/min/1.73 m², we measured SUA, serum pentraxin-3, CRP, urinary protein-to-creatinine ratio, lipid parameters and the severity of CAD as assessed by coronary angiography and quantified by the Gensini lesion severity score. Results: The mean serum values for SUA, pentraxin-3 and CRP in the entire study population were 5.5 ± 1.5 mg/dl, 6.4 ± 3.4 ng/ml and 3.5 ± 2.6 mg/dl, respectively. The Gensini scores significantly correlated in univariate analysis with gender (R = –0.379, p = 0.02), uric acid (R = 0.42, p = 0.001), pentraxin-3 (R = 0.54, p = 0.001), CRP (R = 0.29, p = 0.006) levels, eGFR (R = –0.33, p = 0.02), proteinuria (R = 0.21, p = 0.01), and presence of hypertension (R = 0.37, p = 0.001), but not with smoking status, diabetes mellitus, and lipid parameters. After adjustments for traditional cardiovascular risk factors, only uric acid (R = 0.21, p = 0.02) and pentraxin-3 (R = 0.28, p = 0.01) remained significant predictors of the Gensini score. Conclusions: SUA and pentraxin-3 levels are independent determinants of severity of CAD in patients with mild-to-moderate CKD. We recommend a clinical trial to determine whether lowering uric acid could prevent progression of CAD in patients with CKD.

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Section: Discussionmentioning

confidence: 99%

Uric Acid and Pentraxin-3 Levels Are Independently Associated with Coronary Artery Disease Risk in Patients with Stage 2 and 3 Kidney Disease

Kanbay¹,

Ikizek²,

Solak³

et al. 2011

Am J Nephrol

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“…In light of these findings, C2 may be considered to be an available and easily accessible ED marker. The main reason we chose this method was that it has easy applicability and has been validated in various studies (11,12,16). In some studies, early CV abnormalities ranging from oxidative stress to ED have been shown in ADPKD (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease

Yıldız¹,

Sağ²,

Oruç³

et al. 2017

Turk Neph Dial Transpl

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OBJECTIVE: Early arterial stiffness has been shown in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function. However, to our knowledge, no prospective study evaluated changes in arterial functions in patients with ADPKD. The study aimed to monitor the changes in renal and arterial functions in patients with ADPKD with preserved renal functions. MATERIAL and METHODS:A total of 25 ADPKD patients and 12 controls were included in the study. Data on patient characteristics, biochemical parameters and arterial stiffness were recorded at baseline and at the end of fourth year. Determination of independent correlates of the change in eGFR and arterial functions was performed by linear regression analyses. RESULTS:There was a similar decline in renal functions over the study period in both groups. However, arterial functions deteriorated more rapidly in the ADPKD group. Having ADPKD was the only independent factor associated with the decline in arterial functions. CONCLUSION:There were significant decreases in arterial elasticity characteristics in the ADPKD group compared with the control group despite a similar decline in renal functions. Monitoring of arterial stiffness may be as important as monitoring of renal functions in ADPKD patients. KEy wORDS:Autosomal dominant polycystic kidney disease, Cardiovascular disease, Endothelial dysfunction, Arterial stiffness Öz AMAÇ: Arteriyel sertlik kötü kardiyovasküler sonuçlar ve mortalitenin artması ile ilişkilidir. Renal fonksiyonları korunmuş otozomal dominant polikistik böbrek hastalığı (ODPBH) hastalarında erken arteriyel sertlik görülmüştür. Bununla birlikte, bildiğimiz kadarıyla, ODPBH'li hastalarda prospektif bir çalışmada arteriyel fonksiyon değişiklikleri değerlendirilmemiştir. Bu çalışma, renal fonksiyonları korunmuş olan ODPBH hastalarında böbrek ve arteriyel fonksiyonlarındaki değişiklikleri izlemeyi amaçlamıştır. GEREÇ ve yÖNTEMLER:Çalışmaya toplam 25 ODPBH hastası ve 12 kontrol alındı. Hasta özellikleri, biyokimyasal parametreler ve arteriyel sertlik verileri başlangıçta ve dördüncü yılda kaydedildi. eGFR ve arteriyel fonksiyonlarda meydana gelen değişikliğin bağımsız faktörlerinin belirlenmesi doğrusal regresyon analizi ile gerçekleştirildi. BULGULAR:Her iki grupta da çalışma süresi boyunca böbrek fonksiyonlarında benzer bir düşüş vardı. Bununla birlikte, ODPBH grubunda arteriyel fonksiyonlar daha da kötüleşti. Arteriyel fonksiyonlarda azalma ile ilişkili tek bağımsız faktör, ODPBH olmaktı. SONUÇ:Bu çalışmada, kontrol grubu ile karşılaştırıldığında, ODPBH grubunda böbrek fonksiyonlarında benzer bir düşüşe rağmen, arteriyel elastisite özelliklerinde anlamlı azalmalar vardı. Noninvaziv olarak kolayca ölçülen arteriyel sertliğin izlenmesi, ODPBH hastalarında böbrek fonksiyonlarının izlenmesi kadar önemli olabilir.

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“…We recognize that the most widespread noninvasive technique to assess endothelial function is flow-mediated dilation (FMD). However, FMD is time-consuming, the equipment is very expensive, and it requires an experienced examiner (15). Other techniques available to evaluate arterial elasticity are ultrasound measurement, magnetic resonance imaging, and indirect measures such as pulse pressure.…”

Section: Discussionmentioning

confidence: 99%

“…The average of three replicates for each participant was used for data analyses. Applanation tonometry is based on the principle that when the curved surface of a rounded pressurecontaining chamber (in this case, an artery) is partially flattened, pressures are normalized and a sensor placed on the flattened surface can record the pressure in the chamber (15,16). This technique, which analyzes the signal-averaged radial artery waveform based on a modified Windkessel model, correlates well with other methods that measure hemodynamic parameters in humans (17).…”

Section: Measurements Of Arterial Elasticitymentioning

confidence: 99%

Acute effect of hemodialysis on arterial elasticity

Sağ¹,

Yeşilbursa²,

Yıldız³

et al. 2015

Turk J Med Sci

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Background/aim: Reduced arterial elasticity is an independent predictor of cardiovascular mortality in patients with end-stage renal disease (ESRD). Hemodialysis (HD) treatment per se can bring additional risk factors for vascular disease. Our study was designed to determine whether a single hemodialysis session leads to an acute alteration in parameters of arterial elasticity in ESRD. Materials and methods:In this study, 58 patients undergoing chronic hemodialysis and 29 healthy controls were enrolled. Large artery elasticity index (LAEI) and the small artery elasticity index (SAEI) were measured by applanation tonometry. The acute effect of a hemodialysis session on arterial elasticity indices was assessed by comparison of prehemodialysis and posthemodialysis determinations.Results: At baseline, LAEI did not differ significantly in patients compared with controls. In contrast, the SAEI was significantly lower in patients (4.1 ± 2.6 mL/mmHg × 100) than in healthy individuals (8.9 ± 3.4 mL/mmHg × 100, P < 0.05). In patients with ESRD, no significant changes in LAEI was observed after HD, but SAEI deteriorated significantly (from 4.1 ± 2.6 mL/mmHg × 100 to 3.4 ± 2.3, P < 0.05). Conclusion:We conclude that ESRD patients face a significant reduction in SAEI, which is exacerbated by a dialysis procedure.

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Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid

Cited by 14 publications

References 19 publications

Uric Acid and Pentraxin-3 Levels Are Independently Associated with Coronary Artery Disease Risk in Patients with Stage 2 and 3 Kidney Disease

Uric Acid and Pentraxin-3 Levels Are Independently Associated with Coronary Artery Disease Risk in Patients with Stage 2 and 3 Kidney Disease

Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease

Acute effect of hemodialysis on arterial elasticity

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