Small-Animal SPECT, SPECT/CT, and SPECT/MRI

Meng, Ling-Jian; Clinthorne, N.H.

doi:10.1016/b978-0-12-816386-3.00007-7

Cited by 1 publication

(1 citation statement)

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“…Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) employ radiopharmaceuticals to provide three-dimensional images of the tracer molecules. , Both imaging techniques have the capability to track chemical changes, such as sugar metabolism and antisense recognition, with significant depth penetration. The distinction lies in the detection mechanism: in PET, two oppositely directed photons are detected by the scanner, which offers picomolar sensitivity but is constrained by the limited availability of imaging reagents, such as 18 F. In SPECT, however, the detectors can capture γ rays emitted from various radiolabeled tracers with a corresponding decrease in imaging precision …”

Section: Imaging-assisted Aso Delivery and Cancer Gene Therapymentioning

confidence: 99%

Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy

Liao,

Wang,

Wang

et al. 2024

Chemical & Biomedical Imaging

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Antisense oligonucleotide (ASO) represents a class of practical tools for targeting undruggable oncogenes with several candidates currently undergoing clinical investigation. The advancement of antisense therapeutics necessitates comprehensive approaches for evaluating their efficacy and improving their accuracy. Molecular imaging techniques offer a qualitative and quantitative means to assess therapeutics at the molecular, cellular, and in vivo levels, as well as to elucidate biodistribution and pharmacokinetics. These capabilities play a pivotal role in enhancing therapeutic evaluation and efficiency. This review systematically explores the current landscape of ASO delivery by leveraging a synergistic combination of imaging techniques and delivery vehicles to enhance oligonucleotide distribution and accumulation at tumor sites and thereby optimizing therapeutic outcomes.

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Section: Imaging-assisted Aso Delivery and Cancer Gene Therapymentioning

confidence: 99%