Small animal model of HIV-1 infection

Rytik, P G; Kutcherov, Igor I.; Müller, W.; Poleschuk, Nikolay; Duboiskaya, G. P.; M, Kruzo; Podol'skaya, I. A.

doi:10.1016/j.jcv.2004.09.010

Cited by 7 publications

(6 citation statements)

References 8 publications

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“…Although not demonstrated by direct culture of PBMC or tissues from infected animals, infectious virus replicated at a low level in cotton rats since viral cDNA was detected by PCR in animals that underwent three serial passages of blood. In addition, Rytik and collaborators[ 19 ] detected viral cDNA in spleen and brain of all the infected animals 6 months post-infection, showed increase in mortality (17%), and found morphological changes in cells of the CNS.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, we and others [ 16 - 19 ] have shown evidence of HIV-1 infection in two cotton rat species ( Sigmodon hispidus and S. fulviventer ). In one study [ 16 ] cotton rats inoculated with HIV-1 developed detectable amounts of proviral DNA in peripheral blood mononuclear cells (PBMC).…”

Section: Introductionmentioning

confidence: 94%

“…In another series of studies, Rytik and collaborators [ 17 - 19 ] infected cotton rats ( S. hispidus ) with a Russian isolate of HIV-1. Analysis of the infected animals showed that 75% of the samples from spleen and half of the samples from brain obtained 3 months post-infection contained proviral DNA, whereas all the samples from both tissues obtained 6 months post-infection were positive for proviral DNA.…”

Section: Introductionmentioning

confidence: 99%

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Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection

Blanco¹,

Wieczorek²,

Khetawat

et al. 2009

Virology Journal

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Background: Current small animal models for studying HIV-1 infection are very limited, and this continues to be a major obstacle for studying HIV-1 infection and pathogenesis, as well as for the urgent development and evaluation of effective anti-HIV-1 therapies and vaccines. Previously, it was shown that HIV-1 can infect cotton rats as indicated by development of antibodies against all major proteins of the virus, the detection of viral cDNA in spleen and brain of challenged animals, the transmission of infectious virus, albeit with low efficiency, from animal to animal by blood, and an additional increase in the mortality in the infected groups.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection

Blanco¹,

Wieczorek²,

Khetawat

et al. 2009

Virology Journal

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“…Previously, one laboratory in the U.S. (Langley, Prince, and Ginsberg, 1998) and another in Russia (Rytik et al, 1995;Rytik et al, 2004) demonstrated that HIV-1 was detected in tissues of cotton rats previously infected with HIV-1. In the U.S. study (Langley, Prince, and Ginsberg, 1998), cotton rats were infected with HIV-1 and proviral DNA was detected in peripheral blood mononuclear cells (PBMCs) and tissues including spleen, thymus, and bone marrow from infected animals.…”

Section: Hiv Infection In Cotton Ratmentioning

confidence: 99%

The Quest for a Small Animal Model for HIV Infection and Disease

Blanco¹,

Earle²,

Frels³

2011

HIV-Host Interactions

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“…Rabbits can be experimentally infected with HIV however these animals fail to develop any AIDS-like symptoms despite p24 detection and isolation of HIV from peripheral blood mononuclear cells (PBMC) [69]. Recently it was discovered that cotton rats could be infected with HIV [113] and proviral HIV DNA could be isolated from the spleen and brain. The rats developed fever, weight loss, pulmonary disorders and inflammatory reactions in the brain and spleen.…”

Section: Animals Models For Hiv/aidsmentioning

confidence: 99%

Animal Models Used for the Evaluation of Antiretroviral Therapies

Dias

Bester²,

Britz³

et al. 2006

CHR

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Several animal models for the study of HIV/AIDS have been established and characterized and have been widely used to study the pathogenesis of HIV/AIDS as well as vaccine development. The purpose of this study was to review the literature and identify the animal models most frequently used for the evaluation of drugs, drug combinations, plant extracts and drug-plant combinations. Four of these animal models were evaluated namely the SIV model due to its similarities in pathogenesis of disease to humans, the FIV and the LP-BM5 model due to wide availability and the SCID murine model that combines components of both systems. The pathogenesis of disease in each model, application in the evaluation of drugs, drug combinations and plant extracts as well as the inherent advantages and disadvantages of each model are discussed. The LP-BM5 murine AIDS (MAIDS) model with its in vitro equivalent was identified as the animal model, although not identical to HIV/AIDS, most suitable for the rapid and cost effective initial screening of drugs, drug combinations, plant extracts and drug-plant combinations.

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Small animal model of HIV-1 infection

Cited by 7 publications

References 8 publications

Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection

Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection

The Quest for a Small Animal Model for HIV Infection and Disease

Animal Models Used for the Evaluation of Antiretroviral Therapies

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