Small-airway disease and its reversibility in human immunodeficiency virus-infected children on highly active antiretroviral therapy: A cross-sectional study in an African setting

Ayuk, Adaeze C; Ndukwu, C.I.; Uwaezuoke, Samuel N

doi:10.4103/atm.atm_494_20

Cited by 1 publication

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data regarding prevalence of abnormal spirometry results is summarised in Table 2. The prevalence of low FEV 1 was reported in five papers and ranged from 25.3% to 73% 5,6,10,11,23 . FEV 1 /FVC ratio was reported in 14 studies, 6,10–12,16–19,21–26 and the prevalence of low FEV 1 /FVC ranged from 3% to 26% prebronchodilator.…”

Section: Resultsmentioning

confidence: 97%

“…Twelve papers enrolled participants established on ART 6,10,14,15,18–25 and six papers enrolled participants regardless of their ART status with the percentage on ART ranging from 69% to 97% 5,11–13,26,28 . Three papers did not report ART prevalence 16,17,27 .…”

Section: Resultsmentioning

confidence: 99%

“…Ten papers reported the spirometry data after giving bronchodilator (Table 2). Three papers reported the prevalence of abnormal spirometry parameters post‐bronchodilator 10–12 . Seven papers reported the prevalence of a positive post‐bronchodilator response which ranged from 9% to 35.5% for CALHIV from baseline 16,18,23,25–28 …”

Section: Resultsmentioning

confidence: 99%

“…The eight papers all used Global Lung Function Initiative Standards 2012 to calculate z ‐score, including three papers using African–American option, 14,23,25 one paper using non‑Caucasian “other” option, 10 and four papers did not specify which option of the GLI reference data was used 15,17,20,26 . Eight studies reported FEV 1 z ‐scores, including seven reported mean zFEV 1 10,14,17,20,23,25,26 and two reported median zFEV 1 15,26 . Among those studies, the mean zFEV 1 ranged from −2.19 to −0.73 and median zFEV 1 ranged from −1.94 to −1.31.…”

Section: Resultsmentioning

confidence: 99%

“…16 The African studies reported study populations from South Africa (n = 6), Zimbabwe (n = 9), Malawi (n = 3), Kenya (n = 3), and Nigeria (n = 1). The 21 studies represent 12 distinct study cohorts-six manuscripts involved a distinct study cohort, 5,10,16,[26][27][28] whereas the remaining six study cohorts were analyzed and reported in more than one manuscript. The BREATHE trial was a multicountry trial conducted in Zimbabwe and Malawi, and the findings were reported in two manuscripts.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

See 4 more Smart Citations

A scoping review of lung function in children and adolescents living with HIV in the era of antiretroviral treatment

Liu

Maleche‐Obimbo

Shanthikumar

et al. 2023

Pediatric Pulmonology

View full text Add to dashboard Cite

Background: Human immunodeficiency virus (HIV) in children and adolescents remains an important health challenge in many countries and is commonly associated with lung disease. The introduction of antiretroviral therapy (ART) has greatly improved survival but chronic lung disease is a common ongoing challenge.We conducted a scoping review of studies that have reported lung function in school-aged children and adolescents living with HIV.Methods: A systematic literature search was performed by searching Medline, Embase, and PubMed databases, limited to articles published between 2011 and 2021 in English language. Inclusion criteria were studies involving participants living with HIV aged 5-18 years and having spirometry data. The primary outcome was lung function as measured by spirometry.Results: Twenty-one studies were included in the review. Most study participants were living in the sub-Saharan African region. The prevalence of reduced forced expiratory volume in 1 s (FEV 1 ) ranged from 25.3% to 73% across studies, reduced forced vital capacity (FVC) ranged from 10% to 42% and reduced FEV 1 /FVC ranged from 3% to 26%. The mean z-score of FEV 1 ranged from −2.19 to −0.73, mean zFEV 1 /FVC ranged from −0.74 to 0.2, and mean FVC ranged from −1.86 to −0.63. Conclusion:There is a high prevalence of lung function impairment in children and adolescents living with HIV, which persists in the ART era. Further studies are needed of interventions that might improve lung function in these vulnerable populations.

show abstract

Section: Resultsmentioning

confidence: 97%