SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis
Ricardo Coelho,
Brinton Seashore-Ludlow,
Sarah Schütz
et al.
Abstract:Resistance to chemotherapy and PARPi inhibitors remains a critical challenge in the treatment of epithelial ovarian cancer, mainly due to disabled apoptotic responses in tumor cells. Given mesothelin's pivotal role in ovarian cancer and its restricted expression in healthy tissues, we conducted a drug-screening discovery analysis across a range of genetically modified cancer cells to unveil mesothelin's therapeutic impact. We observed enhanced cell death in low mesothelin expressing cancer cells when exposed t… Show more
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