SMAC is expressed de novoin a subset of cervical cancer tumors

Espinosa, Magali; Cantú, David; Lopez, Carlos M; Garza, Jaime G. De La; Maldonado, Vilma; Meléndez-Zajgla, Jorge

doi:10.1186/1471-2407-4-84

Cited by 14 publications

(11 citation statements)

References 34 publications

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“…In other studies conducted in RCC, no correlation between Smac/DIABLO and stage of disease was observed at the mRNA level (8,12). In cervical cancer, expression of Smac/DIABLO mRNA was not linked with tumor stage (17).…”

Section: Discussionmentioning

confidence: 74%

Correlation of Smac/DIABLO protein expression with the clinico-pathological features of breast cancer patients

Pluta¹,

Cebula-Obrzut²,

Ehemann³

et al. 2011

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Smac/DIABLO protein promotes caspase-dependent apoptosis by inhibition of inhibitor of apoptosis protein (IAP) family members. The role of Smac/DIABLO in breast cancer has not been yet established. Therefore, the aim of the study was to assess the expression of this protein in tumor cells from breast cancer patients. The expression of Smac/DIABLO was analyzed in 62 breast cancer patients by flow cytometry. The obtained results were compared with expression of this protein in benign breast tumor tissue, which served as the control (11 patients with fibroadenoma). Expression of caspase-3 proteins in breast cancer was also evaluated. Smac/DIABLO expression in breast cancer was correlated with clinical and pathological data. Although the expression of Smac/DIABLO protein was found in all examined samples of both the breast cancer and fibroadenoma patients, the median expression of Smac/Diablo in breast cancer was significantly lower than in the control (39.1% vs. 48.1%; p=0.0047). Smac/DIABLO expression correlated with expression of caspase-3 (p=0.000008). In pT1 breast cancer patients, expression of Smac/DIABLO protein was higher than in those with pT2-3 (p=0.02). Diffuse cancer infiltration significantly correlated with lower expression of Smac/DIABLO protein (p=0.02). Moreover, there was a loose correlation between low expression of Smac/DIABLO protein and cancer embolus in minor blood and lymphatic vessels (p=0.08). Our results indicate that expression of Smac/DIABLO inversely correlates with the tumor stage, which may suggest that this protein may play an important role in the breast cancer development.

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Section: Discussionmentioning

confidence: 74%

Correlation of Smac/DIABLO protein expression with the clinico-pathological features of breast cancer patients

Pluta¹,

Cebula-Obrzut²,

Ehemann³

et al. 2011

neo

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“…The members of the inhibitor of apoptosis (IAP) protein family are highly expressed in several classes of cancer. Interestingly, recent studies revealed that Smac is also differentially expressed in cervical tumors and in tumor cell lines [19,20]. These observations have prompted researchers to design Smac mimetic compounds that can be administered either alone or in combination with other chemotherapeutic agents to kill tumor cells.…”

Section: Discussionmentioning

confidence: 98%

Smac/DIABLO is required for effector caspase activation during apoptosis in human cells

et al. 2007

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Mitochondria play a pivotal role during stress-induced apoptosis as several proapoptotic proteins are released to the cytosol to activate caspases. Smac/DIABLO is one of the proapoptotic proteins released from the mitochondria and has been shown to inactivate IAPs. However, gene knockout studies in mice revealed a redundant role for Smac during development and cell death. By applying RNA interference-mediated loss of function approach, we demonstrate that Smac/DIABLO is required for the activation of effector but not initiator caspases during stress and receptor-mediated cell death in HeLa cells. Cells with reduced Smac resist apoptosis and retained clonogenicity. Our results suggest an obligatory role for Smac/DIABLO in these tumor cells during several pathways of apoptosis induction.

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“…Smac/ Diablo mRNA is increased in cancer tissue compared with normal cervical tissue. 23 Hsp60 is elevated in breast cancer cells and correlates with metastatic potential and prognosis. 24 Overexpression of galactins is associated with increased tumor aggressiveness, metastasis and poor prognosis.…”

Section: Research Articlesmentioning

confidence: 99%

The Response of Human Colonocytes to Folate Deficiency in Vitro: Functional and Proteomic Analyses

et al. 2008

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Low folate intake is associated with colon cancer. We combined a proteomics and biochemical approach to identify proteins and pathways affected by folate deficiency in human colonocytes. Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].

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SMAC is expressed de novoin a subset of cervical cancer tumors

Cited by 14 publications

References 34 publications

Correlation of Smac/DIABLO protein expression with the clinico-pathological features of breast cancer patients

Correlation of Smac/DIABLO protein expression with the clinico-pathological features of breast cancer patients

Smac/DIABLO is required for effector caspase activation during apoptosis in human cells

The Response of Human Colonocytes to Folate Deficiency in Vitro: Functional and Proteomic Analyses

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