Sma Therapies I

Developmental central hypotonia: implications for counselling, prognosis, and management

“…Pompe disease, spinal muscular atrophy). 1 Origins in the muscle or lower motor neuron have been rightly emphasized, and the mechanisms for peripheral hypotonia as well as indication for therapy and secondary prevention have been well established in those contexts. However, the vast majority of cases of developmental hypotonia appear to originate in the CNS (i.e.…”