Sma Biomarkers

Abstract

ST; TBZ-score was also negatively related to ST duration up to T4. There was no difference in TBZ-score between DMD with or without fractures. L1-L4 Z-score was not influenced by age, HT, BMI, ST, ambulant status and was more stable than TBZ-score over time. In multiple regression analyses, age was the only negative predictor of TBZ-score up to T4 after correction for HtSD and FM% (R2 between 0,54 and 0,20, P's < 0,05), while logistic regression showed that fractures were predicted by BMI SD after correction for TBZ-score, ST (dose or duration) and not by age or HtSD. In conclusion TBZ-score declines in ambulant DMD over time although a high BMI SD may represent the best predictor of fragility fractures in this cohort.