Slowly progressive aphasia: three cases with language, memory, CT and PET data.

Kempler, Daniel; Metter, E. Jeffrey; Riege, Walter H.; Jackson, Catherine A.; Benson, D. Frank; Hanson, Wayne R.

doi:10.1136/jnnp.53.11.987

Cited by 111 publications

(54 citation statements)

References 15 publications

(5 reference statements)

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“…PET has a better spatial resolution and quantitative accuracy than SPECT, and appears to be a more promising functional imaging technique for the diagnosis and differential diagnosis of dementia [30]. The first PET studies highlighted left temporal lobe involvement [37,74]. Nevertheless, all these above mentioned studies performed using SPECT or PET used either a visual rating or the ROI method for the analysis of brain images.…”

Section: Functional Neuroimaging Methods Such As Single Photon Emissimentioning

confidence: 99%

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges

Matuszewski

Piolino

et al. 2007

Neurobiology of Aging

138

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Rare studies have used MRI and voxel based morphometry (VBM) to assess atrophy, and only two PET studies used SPM to examine functional changes in semantic dementia (SD). Our aim was to highlight both morphological and functional abnormalities in a same group of 10 SD patients, in the entire brain, using a "state of the art" methodology (optimized VBM procedure, PET data corrected for partial volume effects and voxel based analyses). We also used an extensive neuropsychological battery. We showed that main alterations concerned the left temporal lobe, in accordance with the striking impairment of semantic memory in SD patients, as well as the hippocampal region, which may partly explain their moderate episodic memory deficits. Hypometabolism was more extensive than grey matter loss in both temporal lobes, and specifically concerned the orbitofrontal areas, consistent with the moderate impairment of executive functions and behavioural changes. While PET is more sensitive than MRI, there is striking concordance between morphological and functional abnormalities, which contrast with the discordance observed in Alzheimer"s disease and might be a typical feature of SD.3

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Section: Functional Neuroimaging Methods Such As Single Photon Emissimentioning

confidence: 99%

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges

Matuszewski

Piolino

et al. 2007

Neurobiology of Aging

138

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“…All subtests involved complete declarative sentences referring to a full state of affairs (referent/s and predication). They spanned a range of sentence types, comprising different levels of morphosyntactic complexity, ranging from simple constructions (simple declaratives and possession: levels 2 and 3) to more elaborated structures (active voice, passive voice, double embedding: levels 4, 5, 6) and complex structures (object clefting, subject relative clauses, negative passives, object relative clauses, and object relative clauses with relativized object: levels 7,8,9). The numbers denominating the levels correspond to the age at which children normally learn to comprehend the considered type of sentence.…”

Section: Syntactic Comprehensionmentioning

confidence: 99%

“…1,3,7,28 However, the association of specific PPA clinical variants with discrete regions in the speech and language network remains vague. The anatomical basis of the cognitive impairment in SD has been investigated previously, 29-32 but no study has directly compared SD with other variants of PPA.…”

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confidence: 99%

Cognition and anatomy in three variants of primary progressive aphasia

Gorno‐Tempini

Dronkers

Rankin

et al. 2004

Annals of Neurology

1,370

131

1,437

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We performed a comprehensive cognitive, neuroimaging, and genetic study of 31 patients with primary progressive aphasia (PPA), a decline in language functions that remains isolated for at least 2 years. Detailed speech and language evaluation was used to identify three different clinical variants: nonfluent progressive aphasia (NFPA; n = 11), semantic dementia (SD; n = 10), and a third variant termed logopenic progressive aphasia (LPA; n = 10). Voxel-based morphometry (VBM) on MRIs showed that, when all 31 PPA patients were analyzed together, the left perisylvian region and the anterior temporal lobes were atrophied. However, when each clinical variant was considered separately, distinctive patterns emerged: (1) NFPA, characterized by apraxia of speech and deficits in processing complex syntax, was associated with left inferior frontal and insular atrophy; (2) SD, characterized by fluent speech and semantic memory deficits, was associated with anterior temporal damage; and (3) LPA, characterized by slow speech and impaired syntactic comprehension and naming, showed atrophy in the left posterior temporal cortex and inferior parietal lobule. Apolipoprotein E ε4 haplotype frequency was 20% in NFPA, 0% in SD, and 67% in LPA. Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes.Isolated speech and language difficulties are often the first symptoms of focal forms of neurodegenerative diseases, particularly frontotemporal lobar degeneration (FTLD) and corticobasal degeneration (CBD). 1,2 Alzheimer's disease (AD) patients also have been shown to present with atypical focal cognitive manifestations, including fluent and nonfluent progressive aphasia. 3-7 When speech and language deficits remain the only complaint for at least 2 years, the term primary progressive aphasia (PPA) has been applied. 8Pathologically, the most frequent finding in PPA is an FTLD-type of damage such as dementia lacking distinctive pathology (DLDH) 9-11 or Pick's disease. 12,13 Cases with AD, 3 Creutzfeldt-Jakob disease, 1,4 and FTLD with motor neuron disease (FTLD-MND) pathology also have been reported 15 (for review, see Mesulam, 16 Grossman, 17 and Black 18 ). Kertesz first included CBD in the FTLD/Pick's spectrum of diseases and recently reported four PPA cases with pathologically proven CBD. 12,19 Address correspondence to Dr Gorno-Tempini, UCSF Memory and Aging Center, 350 Parnassus Avenue, Suite 706, Box 1207. San Francisco, CA 94143. E-mail: marilu@itsa.ucsf.edu. NIH Public Access Author ManuscriptAnn Neurol. Author manuscript; available in PMC 2008 May 1. Published in final edited form as:Ann Neurol. 2004 March ; 55(3): 335-346. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptDifferent clinical presentations of PPA have been reported, but large studies that investigate both cognitive and neuroimaging findings in the same group of patients are still lacking. Here, we consider the clinical variants that have be...

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“…Evidence from functional neuroimaging (e.g. PET, SPECT, and fMRI) and postmortem examinations points to abnormalities in the frontal, perisylvian and temporal cortices, regions normally involved in language function (Chawluk et al, 1986;Kempler et al, 1990;McDaniel, Wagner, & Greenspan, 1991;Mesulam & Weintraub, 1992a;Radanovic et al, 2001;Turner, Kenyon, Trojanowski, Gonatas, & Grossman, 1996).…”

Section: Introductionmentioning

confidence: 99%

False recognition of incidentally learned pictures and words in primary progressive aphasia

et al. 2007

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Recognition memory was tested in patients with primary progressive aphasia (PPA), a language based dementia with relative preservation of memory for at least the first 2 years. The goal of the study was two-fold: (1) to compare true and false recognition rates for words versus pictures in patients with PPA and cognitively intact controls and (2) to determine if the semantic relatedness of distracters-to-targets influences recognition memory performance. Overall, performance of PPA patients was worse for words than pictures. PPA patients and healthy elderly controls showed similar recognition rates for studied items. However, the patients had significantly more false alarms than controls, particularly to semantically related items. This suggests that the aphasia in PPA patients contributes to their difficulty in selecting among items within a semantic class.

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Slowly progressive aphasia: three cases with language, memory, CT and PET data.

Cited by 111 publications

References 15 publications

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Cognition and anatomy in three variants of primary progressive aphasia

False recognition of incidentally learned pictures and words in primary progressive aphasia

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