Slowly activating voltage-gated potassium current potentiation by ML277 is a novel cardioprotective intervention
Sean Brennan,
Abrar I M Alnaimi,
Lauren R McGuinness
et al.
Abstract:Cardiovascular disease is thought to account for nearly a third of deaths worldwide, with ischemic heart disease, including acute coronary syndromes such as myocardial infarction, accounting for 1.7 million deaths per year. There is a clear need for interventions to impart cardioprotection against ischemia. Here, we show that the IKs current potentiator ML277 imparts cardioprotection against ischemia in cellular and whole heart models by modulating the action potential duration. In three different metabolic in… Show more
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