Slowed Compensation Responses to Altered Auditory Feedback in Post-Stroke Aphasia: Implications for Speech Sensorimotor Integration

Johnson, Lorelei Phillip; Sangtian, Stacey; Johari, Karim; Behroozmand, Roozbeh; Fridriksson, Julius

doi:10.1016/j.jcomdis.2020.106034

Cited by 15 publications

(3 citation statements)

References 59 publications

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“…Other NIBS studies targeting other brain regions have shown that a-tDCS over the right cerebellum prolonged the peak times of vocal responses to pitch perturbations (Peng et al, 2021), while cTBS over the right cerebellum (Lin et al, 2022) or the left or right SMG (Li et al, 2023) shortened them. Prolonged vocal responses to pitch perturbations have been observed in patients with PD (Kiran and Larson, 2001) or aphasia (Johnson et al, 2020), reflecting their impaired sensorimotor integration in speech processing. However, these prolonged vocal responses can be normalized by intensive voice training in patients with PD (Li et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation

Chang,

Peng,

Zhao

et al. 2023

Front. Neurosci.

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BackgroundA growing body of literature has implicated the left dorsolateral prefrontal cortex (DLPFC) in the online monitoring of vocal production through auditory feedback. Specifically, disruption of or damage to the left DLPFC leads to exaggerated compensatory vocal responses to altered auditory feedback. It is conceivable that enhancing the cortical excitability of the left DLPFC may produce inhibitory influences on vocal feedback control by reducing vocal compensations.MethodsWe used anodal transcranial direct current stimulation (a-tDCS) to modulate cortical excitability of the left DLPFC and examined its effects on auditory-motor integration for vocal pitch regulation. Seventeen healthy young adults vocalized vowel sounds while hearing their voice pseudo-randomly pitch-shifted by ±50 or ±200 cents, either during (online) or after (offline) receiving active or sham a-tDCS over the left DLPFC.ResultsActive a-tDCS over the left DLPFC led to significantly smaller peak magnitudes and shorter peak times of vocal compensations for pitch perturbations than sham stimulation. In addition, this effect was consistent regardless of the timing of a-tDCS (online or offline stimulation) and the size and direction of the pitch perturbation.ConclusionThese findings provide the first causal evidence that a-tDCS over the left DLPFC can facilitate auditory-motor integration for compensatory adjustment to errors in vocal output. Reduced and accelerated vocal compensations caused by a-tDCS over left DLPFC support the hypothesis of a top–down neural mechanism that exerts inhibitory control over vocal motor behavior through auditory feedback.

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Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation

Chang,

Peng,

Zhao

et al. 2023

Front. Neurosci.

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“…In post-stroke aphasia , the classic behavioral measure of auditory-motor disruption is speech repetition, where errors reflect a breakdown of the mapping from afferent speech input (the auditory target) to motor-articulatory representations ( Hickok & Poeppel, 2004 ). The idea that the left-hemisphere lesions that cause aphasia may also damage the sensorimotor network for speech feedback processing is suggested by altered auditory feedback studies, in which persons with aphasia (PWA) make slower and/or smaller adjustments in response to externally applied pitch perturbations ( Behroozmand et al, 2018 ; Behroozmand et al, 2022 ; Johnson et al, 2020 ). While these laboratory assays help to pinpoint the anatomical and functional bases of speech motor impairments, they fall short of addressing how PWA achieve, or fail to achieve, accuracy in their own volitional speech—in which the auditory target is speaker-internal (i.e., unlike a repetition task) and the feedback is veridical (i.e., unlike an altered auditory feedback paradigm).…”

Section: Introductionmentioning

confidence: 99%

Pars Opercularis Underlies Efferent Predictions and Successful Auditory Feedback Processing in Speech: Evidence From Left-Hemisphere Stroke

Beach,

Tang,

Kiran

et al. 2024

Neurobiology of Language

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Hearing one’s own speech allows for acoustic self-monitoring in real time. Left-hemisphere motor planning regions are thought to give rise to efferent predictions that can be compared to true feedback in sensory cortices, resulting in neural suppression commensurate with the degree of overlap between predicted and actual sensations. Sensory prediction errors thus serve as a possible mechanism of detection of deviant speech sounds, which can then feed back into corrective action, allowing for online control of speech acoustics. The goal of this study was to assess the integrity of this detection-correction circuit in persons with aphasia (PWA) whose left-hemisphere lesions may limit their ability to control variability in speech output. We recorded magnetoencephalography (MEG) while 15 PWA and age-matched controls spoke monosyllabic words and listened to playback of their utterances. From this, we measured speaking-induced suppression of the M100 neural response and related it to lesion profiles and speech behavior. Both speaking-induced suppression and cortical sensitivity to deviance were preserved at the group level in PWA. PWA with more spared tissue in pars opercularis had greater left-hemisphere neural suppression and greater behavioral correction of acoustically deviant pronunciations, whereas sparing of superior temporal gyrus was not related to neural suppression or acoustic behavior. In turn, PWA who made greater corrections had fewer overt speech errors in the MEG task. Thus, the motor planning regions that generate the efferent prediction are integral to performing corrections when that prediction is violated.

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“…In post-stroke aphasia, the classic behavioral measure of auditory-motor disruption is speech repetition, where errors reflect a breakdown of the mapping from afferent speech input (the auditory target) to motor-articulatory representations (Hickok & Poeppel, 2004). The idea that the left-hemisphere lesions that cause aphasia may also damage the sensorimotor network for speech feedback processing is suggested by altered auditory feedback studies, in which persons with aphasia (PWA) make slower and/or smaller adjustments in response to externally applied pitch perturbations (Behroozmand et al, 2018; Johnson et al, 2020; Behroozmand et al, 2022). While these laboratory assays help to pinpoint the anatomical and functional bases of speech motor impairments, they fall short of addressing how PWA achieve, or fail to achieve, accuracy in their own volitional speech – in which the auditory target is speaker-internal and the feedback is veridical.…”

Section: Introductionmentioning

confidence: 99%

Pars opercularis underlies efferent predictions and successful auditory feedback processing in speech: Evidence from left-hemisphere stroke

Beach,

Tang,

Kiran

et al. 2023

Preprint

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Hearing one's own speech allows for acoustic self-monitoring in real time. Left-hemisphere motor planning regions are thought to give rise to efferent predictions that can be compared to true feedback in sensory cortices, resulting in neural suppression commensurate with the degree of overlap between predicted and actual sensations. Sensory prediction errors thus serve as a possible mechanism of detection of deviant speech sounds, which can then feed back into corrective action, allowing for online control of speech acoustics. The goal of this study was to assess the integrity of this detection-correction circuit in persons with aphasia (PWA) whose left-hemisphere lesions may limit their ability to control variability in speech output. We recorded magnetoencephalography (MEG) while 15 PWA and age-matched controls spoke monosyllabic words and listened to playback of their utterances. From this, we measured speaking-induced suppression of the M100 neural response and related it to lesion profiles and speech behavior. Both speaking-induced suppression and cortical sensitivity to deviance were preserved at the group level in PWA. PWA with more spared tissue in pars opercularis had greater left-hemisphere neural suppression and greater behavioral correction of acoustically deviant pronunciations, whereas sparing of superior temporal gyrus was not related to neural suppression or acoustic behavior. In turn, PWA who made greater corrections had fewer overt speech errors in the MEG task. Thus, the motor planning regions that generate the efferent prediction are integral to performing corrections when that prediction is violated.

show abstract

Slowed Compensation Responses to Altered Auditory Feedback in Post-Stroke Aphasia: Implications for Speech Sensorimotor Integration

Cited by 15 publications

References 59 publications

Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation

Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation

Pars Opercularis Underlies Efferent Predictions and Successful Auditory Feedback Processing in Speech: Evidence From Left-Hemisphere Stroke

Pars opercularis underlies efferent predictions and successful auditory feedback processing in speech: Evidence from left-hemisphere stroke

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