Slow-wave sleep and androgens: selective slow-wave sleep suppression affects testosterone and 17α-hydroxyprogesterone secretion

Ukraintseva, Yu. V.; Liaukovich, Krystsina; Полищук, А. А.; Martynova, Olga; Belov, D.A.; Сименел, Е С; Cruz, Miguel Meira e; Nizhnik, Alexander N.

doi:10.1016/j.sleep.2018.04.012

Cited by 12 publications

(5 citation statements)

References 42 publications

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“…For instance, total sleep deprivation and 4.5 h of sleep restricted to the first night‐half significantly reduced morning T concentrations in a study of 15 young and healthy men (27.1 ± 1.32 years; BMI, 22.9 ± 0.3 kg/m 2 ) 20 . This is consistent with the reduction in androgen secretion associated with suppression of SWS 21 . T secretion is pulsatile, following a circadian and ultradian rhythm.…”

Section: Discussionsupporting

confidence: 53%

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Association of sleep duration and quality with serum testosterone concentrations among men and women: NHANES 2011–2016

et al. 2023

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BackgroundThe association between testosterone concentrations and sleep duration is poorly understood.ObjectiveTo evaluate the association between sleep duration and quality with serum testosterone concentrations and its variation by sex and age.MethodsData were analyzed for 8748 men and women (≥20 years old) who participated in the cycles of the National Health and Nutrition Examination Survey 2011–2016, a cross‐sectional study. Total testosterone (ng/dL) was measured and categorized (low, moderate, and high) based on established cut‐offs for men and its tertile distribution among women. Sleep duration was classified as ≤6, 7–8, and ≥9 h. Sleep quality was classified as poor or good based on the frequency of trouble falling or staying asleep or sleeping too much. Weighted multivariable adjusted and multinomial logistic regression models were conducted to assess these associations.ResultsThe association between sleep duration and testosterone concentrations, varied according to sex and age. Sleep deprivation (≤6 h) was associated with high testosterone (odds ratio = 3.62; 95% confidence interval: 1.37, 9.53) among young men (20–40 years old); meanwhile, middle‐aged men (41–64 years old) who reported more sleep duration had low testosterone (odds ratio = 2.03; 95% confidence interval: 1.10, 3.73). A J‐shaped association between sleep duration and low testosterone (odds ratio≤6 h = 1.57; 95% confidence interval: 1.10, 2.27; odds ratio≥9 h = 2.06; 95% confidence interval: 1.18, 3.59) was observed in women aged 41–64 years. We did not find any association with sleep quality.ConclusionThe association of sleep duration with serum testosterone concentrations varies with sex and age group. Prospective studies are warranted to confirm these sex and age group differences.

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Section: Discussionsupporting

confidence: 53%

“…20 This is consistent with the reduction in androgen secretion associated with suppression of SWS. 21 T secretion is pulsatile, following a circadian and ultradian rhythm. Serum T concentrations begin to rise after falling asleep, until the onset of REM, 39 and the highest T peak is reached upon waking.…”

Section: Ta B L Ementioning

confidence: 99%

Association of sleep duration and quality with serum testosterone concentrations among men and women: NHANES 2011–2016

et al. 2023

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“…Slow-wave sleep plays an important role in regulating the synthesis and secretion of androgens [16]. Ukraintseva et al investigated the effect of suppression of slow-wave sleep (SWS) on, among others, morning androgen levels and demonstrated reduced testosterone and 17-hydroxyprogesterone levels in men subjected to SWS suppression [16]. The results of this study suggest that chronic sleep problems, especially those that interfere with deep sleep, increase the risk of developing androgen deficiency.…”

Section: -Hydroxyprogesterone Concentrationmentioning

confidence: 69%

“…Steroid hormones such as androgens are also subject to the circadian rhythm, and their concentration fluctuates with the sleep-wake phase [16]. Due to the nature of the work, flight attendants are prone to sleep disturbance.…”

Section: -Hydroxyprogesterone Concentrationmentioning

confidence: 99%

“…In the study, we showed that both testosterone and 17-hydroxyprogesterone levels were significantly lower than in the control group. Slow-wave sleep plays an important role in regulating the synthesis and secretion of androgens [16]. Ukraintseva et al investigated the effect of suppression of slow-wave sleep (SWS) on, among others, morning androgen levels and demonstrated reduced testosterone and 17-hydroxyprogesterone levels in men subjected to SWS suppression [16].…”

Section: -Hydroxyprogesterone Concentrationmentioning

confidence: 99%

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Diurnal Cortisol Rhythm in Female Flight Attendants

Radowicka

Pietrzak

Wielgoś

2021

IJERPH

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The work of flight attendants is associated with exposure to long-term stress, which may cause increased secretion of cortisol. The aim of the study is to determine the circadian rhythm of cortisol and to seek factors of potential influence on the secretion of cortisol in female flight attendants working within one time zone as well as on long-distance flights. The prospective study covers 103 women aged 23–46. The study group (I) was divided into two subgroups: group Ia, comprising female flight attendants flying within one flight zone, and group Ib, comprising female flight attendants working on long-distance flights. The control group (II) are women of reproductive age who sought medical assistance due to marital infertility in whom the male factor was found to be responsible for problems with conception in the course of the diagnostic process. The assessment included: age, BMI, menstrual cycle regularity, the length of service, the frequency of flying, diurnal profile of the secretion of cortisol, testosterone, estradiol, 17-OH progesterone, SHBG, androstenedione, and progesterone concentration. Descriptive methods and inferential statistics methods were used to compile the data. Comparing the profile of flight attendants from groups Ia and Ib shows that the curve flattened among women flying within one time zone. The secretion curve is also more flattened in women with less years worked and in flight attendants working less than 60 h per month. Due to the character of work, the female flights attendants do not have hypersecretion of cortisol. Frequency of flying and length of work affect the dysregulation of HPA axis.

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Effects of Testosterone in Mediating the Relationship Between Daytime Napping and Osteoporosis in European Populations: A Mendelian Randomization Study

Zhang,

Jiang,

Shang

et al. 2024

Calcif Tissue Int

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Slow-wave sleep and androgens: selective slow-wave sleep suppression affects testosterone and 17α-hydroxyprogesterone secretion

Cited by 12 publications

References 42 publications

Association of sleep duration and quality with serum testosterone concentrations among men and women: NHANES 2011–2016

Association of sleep duration and quality with serum testosterone concentrations among men and women: NHANES 2011–2016

Diurnal Cortisol Rhythm in Female Flight Attendants

Effects of Testosterone in Mediating the Relationship Between Daytime Napping and Osteoporosis in European Populations: A Mendelian Randomization Study

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