Slow Viral Infections

Brooks, Benjamin Rix; Jubelt, Burk; Swarz, Jeffrey R.; Johnson, Richard T.

doi:10.1146/annurev.ne.02.030179.001521

Cited by 13 publications

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“…Because she left peninsular Malaysia for Sarawak, which was free of Nipah virus, we can be certain that the interval of 4 months represents a true late presentation between rather than a re-exposure. Similarly, one of the three human cases of Hendra encephalitis occurred 13 months after the initial exposure,3 and measles virus, another paramyxovirus, causes subacute sclerosing panencephalitis many years after initial exposure 1213 The IgM capture ELISA and indirect IgG ELISA against Hendra virus used during the Nipah outbreak in 1998 were positive in serum samples of about 70% of patients, and CSF of about 30% 4…”

Section: Discussionmentioning

confidence: 99%

Late presentation of Nipah virus encephalitis and kinetics of the humoral immune response

Wong

2001

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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Nipah virus is a newly discovered paramyxovirus transmitted directly from pigs to humans. During a large encephalitis outbreak in Malaysia and Singapore in 1998-9, most patients presented acutely. A 12 year old child is described who developed encephalitis 4 months after exposure to the virus. She was diagnosed by a new indirect IgG enzyme linked immunosorbent assay (ELISA), which is also described. The late presentation and IgG subclass responses had similarities to subacute sclerosing panencephalitis. Nipah virus should be considered in patients with encephalitis even months after their possible exposure. (J Neurol Neurosurg Psychiatry 2001;71:552-554)

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Section: Discussionmentioning

confidence: 99%

Late presentation of Nipah virus encephalitis and kinetics of the humoral immune response

Wong

2001

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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“…Postinfectious encephalitis with perivenular demyelination also occurs as a rare complication of vaccinia, varicella, and rubella infections (Spillane and Wells, 1964;Griffith et al, 1970) and probably also occurred in smallpox (Marsden and Hurst, 1932). In contrast to the situation with measles virus, vaccinia and varicella have been recovered from brains and CSF (Angulo et al, 1964;Brooks et al, 1979;Peters et al, 1978). Central nervous system demyelination has also been documented following mumps, influenza, and Epstein-Barr virus infections (Schwarz et al, 1964;Hoult and Flewett, 1960).…”

Section: A Postin Fectio Us Encephalomyelitismentioning

confidence: 99%

Virus induced demyelination

Fazakerley¹,

Dyson²,

Simas³

1994

Journal of Neuroimmunology

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Quantification of de novo central nervous system igg measles antibody synthesis in sspe

Tourtellotte

Booe

Brandes

et al. 1981

Annals of Neurology

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De novo central nervous system (CNS) IgG measles antibody synthesis rate was determined in two patients with subacute sclerosing panencephalitis (SSPE). Cerebrospinal fluid and sera were incubated with different concentrations of measles virus to determine maximum absorption of IgG. The difference in IgG concentration before and after incubation was considered the amount of measles-specific IgG antibody. Various tests were done to assess the immunological specificity of the absorption test. Using our empirical formula, the de novo CNS IgG measles antibody synthesis rate for one patient with SSPE was 57 mg/day, or 59% of the total CNS IgG synthesis rate; for the other it was 145 mg/day, or 82%. Daily determination of CNS measles antibody by empirical formula provides a quantification of humoral immunity in SSPE that corrects for both passage of measles antibody across a damaged blood-brain barrier and the effect of an elevated blood antibody level.

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Slow Viral Infections

Cited by 13 publications

References 0 publications

Late presentation of Nipah virus encephalitis and kinetics of the humoral immune response

Late presentation of Nipah virus encephalitis and kinetics of the humoral immune response

Virus induced demyelination

Quantification of de novo central nervous system igg measles antibody synthesis in sspe

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