Slow sulfide donor GYY4137 potentiates effect of paclitaxel on colorectal carcinoma cells

Kajsik, Marek; Chovancova, Barbora; Lišková, Veronika; Babula, Petr; Križanová, Oľga

doi:10.1016/j.ejphar.2022.174875

Cited by 10 publications

(14 citation statements)

References 36 publications

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“…In other CRC cell lines (e.g. HCT116, SW620, DLD1), GYY4137 also increases the sensitivity of CRC cells to paclitaxel to promote apoptosis [ 89 ]. S-adenosyl-L-methionine (SAM), a metabolic activator at low to moderate levels of CBS, produces H 2 S as an endogenous pro-growth and bioenergetic factor in early stages of colon carcinogenesis, but high doses of SAM downregulate CBS expression and inhibit cancer cell bioenergetics and proliferation [ 90 ].…”

Section: The Roles Of H 2 S In Apoptosis In Differ...mentioning

confidence: 99%

The potential role of hydrogen sulfide in cancer cell apoptosis

Gao,

Liu,

Zhang

et al. 2024

Cell Death Discov.

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For a long time, hydrogen sulfide (H2S) has been considered a toxic compound, but recent studies have found that H2S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions. Currently, a large number of studies have shown that H2S mediates apoptosis through multiple signaling pathways to participate in cancer occurrence and development, for example, PI3K/Akt/mTOR and MAPK signaling pathways. Therefore, the regulation of the production and metabolism of H2S to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment. In this review, the role and mechanism of H2S in cancer cell apoptosis in mammals are summarized.

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Section: The Roles Of H 2 S In Apoptosis In Differ...mentioning

confidence: 99%

The potential role of hydrogen sulfide in cancer cell apoptosis

Gao,

Liu,

Zhang

et al. 2024

Cell Death Discov.

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show abstract

“…Researchers have also proposed a new combination therapy strategy based on the mechanism of action of GYY4137 in CRC. Kajsik et al reported that GYY4137 could be used to increase the sensitivity of CRC cells to the potent chemotherapeutic agent paclitaxel, which is commonly used in the treatment of a variety of cancers but has low efficacy in CRC [ 191 ].…”

Section: H 2 S Diagnosis and Treatment Strategies ...mentioning

confidence: 99%

Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

Lin¹,

Yang²,

Zhu³

et al. 2023

Redox Biology

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“…Paclitaxel, another well-known chemotherapeutic medication, inhibits microtubule disintegration by binding to -tubulin and stabilizing the polymerized structural component [45]. This reduces the cell machinery's ability to partition chromatids to the two centrosomederived poles and, on a cellular level, causes mitotic arrest in metaphase since the next phase (anaphase) is dependent on the shortening and retraction of the spindle fibers [46,47].…”

Section: Mitosis and The G2 Phasementioning

confidence: 99%