Slow Oscillation in Non-Lemniscal Auditory Thalamus

He, Jufang

doi:10.1523/jneurosci.23-23-08281.2003

Cited by 50 publications

(43 citation statements)

References 101 publications

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“…1 A) indicated that 2 of 4 cells recorded in the ventral division (lemniscal nucleus) and 4 of 5 cells in the dorsal and caudomedial divisions (nonlemniscal nucleus) of the MGB showed up and down states, suggesting that slow oscillations are more prominent in the nonlemniscal nucleus. Similar to that reported previously (He, 2003), we found that the auditory response latency of the nonlemniscal neurons (29.0 Ϯ 15.7 ms, SD, n ϭ 5) was longer than that of the lemniscal cells (15.2 Ϯ 3.8 ms, n ϭ 4) in the population of neurobiotin-labeled neurons. We thus used response latency as a criterion to select two groups of cells from the recorded pool: lemniscal cell-like (with latency Ͻ10 ms) and nonlemniscal cell-like (with latency Ͼ20 ms).…”

Section: Bistable Membrane Potentials Of Auditory Thalamic Neurons Insupporting

confidence: 90%

“…The average interval between the onset times of two adjacent down states (equivalent to the sum of the mean durations of up and down states) was 10.1 Ϯ 5.7 s (SD, n ϭ 121; range, 2 to 30 s) (Fig. 1 E), consistent with the frequency of previously observed slow oscillations in auditory thalamic neurons (He, 2003). For each given cell, the interval was highly variable (Fig.…”

Section: Bistable Membrane Potentials Of Auditory Thalamic Neurons Insupporting

confidence: 86%

“…Earlier studies using extracellular recordings have shown that sound stimulation can modulate the frequency of slow oscillations in nonlemniscal MGB neurons of anesthetized guinea pigs (He, 2003). Intracellular recordings from anesthetized animals in the present study further demonstrate that sound stimulation can entrain the up-to-down transitions of the membrane potential of these neurons.…”

Section: Entrainment Of Slow Oscillationssupporting

confidence: 75%

“…For example, visual stimulation increased the duration of the up state in cat cortical neurons (Anderson et al, 2000), and air-puff stimulation of the rat vibrissae evoked either up-to-down or down-to-up membrane potential transition in cerebellar Purkinje cells (Loewenstein et al, 2005;Schonewille et al, 2006). In the auditory thalamus, slow oscillations of neuronal activity have been observed in anesthetized animals, and extracellular recordings showed that repetitive sound stimulation could elicit regular oscillations of thalamic neurons (He, 2003). Although the interactions between sensory stimulation and ongoing network oscillations are likely to play important roles in various brain functions, experimental characterization of these interactions remains incomplete.…”

Section: Introductionmentioning

confidence: 99%

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Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli

Gao

Meng²,

Ye³

et al. 2009

J. Neurosci.

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Slow oscillations at frequencies Ͻ1 Hz manifest in many brain regions as discrete transitions between a depolarized up state and a hyperpolarized down state of the neuronal membrane potential. Although up and down states are known to differentially affect sensoryevoked responses, whether and how they are modulated by sensory stimuli are not well understood. In the present study, intracellular recording in anesthetized guinea pigs showed that membrane potentials of nonlemniscal auditory thalamic neurons exhibited spontaneous up/down transitions at random intervals in the range of 2-30 s, which could be entrained to a regular interval by repetitive sound stimuli. After termination of the entraining stimulation (ES), regular up/down transitions persisted for several cycles at the ES interval. Furthermore, the efficacy of weak sound stimuli in triggering the up-to-down transition was potentiated specifically at the ES interval for at least 10 min. Extracellular recordings in the auditory thalamus of unanesthetized guinea pigs also showed entrainment of slow oscillations by rhythmic sound stimuli during slow wave sleep. These results demonstrate a novel form of network plasticity, which could help to retain the information of stimulus interval on the order of seconds.

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Section: Bistable Membrane Potentials Of Auditory Thalamic Neurons Insupporting

confidence: 90%

Section: Bistable Membrane Potentials Of Auditory Thalamic Neurons Insupporting

confidence: 86%

Section: Entrainment Of Slow Oscillationssupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli

Gao

Meng²,

Ye³

et al. 2009

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…First, burst firing acts as an effective relay and amplifying signal in vivo [68][69][70][71]. Burst firing performs better signal detection [70,72], effectively relays auditory information in a non-linear input-output manner, regulates the frequency selectivity of MGB neurons [70,73,74], and may be involved in the generation of oscillations [75,76]. Second, RD and rebound spikes may be directly responsible for neuronal off-responses [8,77,78], which are shown by MGB neurons [79,80].…”

Section: Kir Channels Regulate Rd By Changing the Resting Membrane Pomentioning

confidence: 99%

Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro

et al. 2016

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Rebound depolarization (RD) is a response to the offset from hyperpolarization of the neuronal membrane potential and is an important mechanism for the synaptic processing of inhibitory signals. In the present study, we characterized RD in neurons of the rat medial geniculate body (MGB), a nucleus of the auditory thalamus, using whole-cell patch-clamp and brain slices. RD was proportional in strength to the duration and magnitude of the hyperpolarization; was effectively blocked by Ni 2? or Mibefradil; and was depressed when the resting membrane potential was hyperpolarized by blocking hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with ZD7288 or by activating G-protein-gated inwardly-rectifying K ? (GIRK) channels with baclofen. Our results demonstrated that RD in MGB neurons, which is carried by T-type Ca 2? channels, is critically regulated by HCN channels and likely by GIRK channels.

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The subcortical auditory structures in the Mongolian gerbil: II. Frequency‐related topography of the connections with cortical field AI

Budinger

Brosch

Scheich

et al. 2013

J of Comparative Neurology

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We investigated the frequency-related topography of connections of the primary auditory cortical field (AI) in the Mongolian gerbil with subcortical structures of the auditory system by means of the axonal transport of two bidirectional tracers, which were simultaneously injected into regions of AI with different best frequencies (BFs). We found topographic, most likely frequency-matched (tonotopic) connections as well as non-topographic (non-tonotopic) connections. AI projects in a tonotopic way to the ipsilateral ventral (MGv) and dorsal divisions (MGd) of the medial geniculate body (MGB), the reticular thalamic nucleus and dorsal nucleus of the lateral lemniscus, and the ipsi- and contralateral dorsal cortex of the inferior colliculus (IC) and central nucleus of the IC. AI receives tonotopic inputs from MGv and MGd. Projections from different BF regions of AI terminate in a non-tonotopic way in the ipsilateral medial division of the MGB (MGm), the suprageniculate thalamic nucleus (SG) and brachium of the IC (bic), and the ipsi- and contralateral external cortex and pericollicular areas of the IC. The anterograde labeling in the intermediate and ventral nucleus of the lateral lemniscus, parts of the superior olivary complex, and divisions of the cochlear nucleus was generally sparse; thus a clear topographic arrangement of the labeled axons could not be ruled out. AI receives non-tonotopic inputs from the ipsilateral MGm, SG, and bic. In conclusion, the tonotopic and non-tonotopic corticofugal connections of AI can potentially serve for both conservation and integration of frequency-specific information in the respective target structures.

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Slow Oscillation in Non-Lemniscal Auditory Thalamus

Cited by 50 publications

References 101 publications

Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli

Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli

Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro

The subcortical auditory structures in the Mongolian gerbil: II. Frequency‐related topography of the connections with cortical field AI

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