Slow, Natural Reduction in Blood Lead Level After Chelation Therapy for Lead Poisoning in Childhood

Description of 3,180 Courses of Chelation with Dimercaptosuccinic Acid in Children ≤5 y with Severe Lead Poisoning in Zamfara, Northern Nigeria: A Retrospective Analysis of Programme Data

“…In patients with VBLL ≥ 120 µg/dl, it was notable that the ECP achieved by the first course was substantially better than that achieved by subsequent courses. This finding has also been observed with lead chelation of severely poisoned patients treated with CaNa 2 EDTA [12] , [54] , [55] . Similarly, within courses of chelation with CaNa 2 EDTA and DMSA, the largest change in VBLL and urinary lead excretion is usually observed during the first 1–2 d of treatment [26] , [27] , [55] , [56] .…”

Lead Intoxication from Ingestion of Fishing Sinkers: A Case Study and Review of the Literature

“…Most studies monitor longitudinal declines in lead levels of children who have had long-term, not short-term, exposure to lead. Moel et al 23 described the rate of decline in blood lead levels in children after chelation therapy. However, these children had levels exceeding 100 μg/dL and were only followed up until their levels fell to 70 μg/dL.…”

The efficacy of chelation therapy and factors influencing mortality in lead intoxicated petrol sniffers

“…The decrease in blood lead concentrations from admission to the end of IM chelation was also comparable to decreases of 60-7OYo in the blood lead concentrations of occupationally exposed males receiving either EDTA/BAL therapy or oral dimercaptosuccinic acid (DMSA) the~apy'~,'~ or children receiving EDTA/BAL therapy. 28 Both d-ALAD activity and FEP concentration reflect inorganic lead exposure and are not affected directly by alkylleads.'." Depressed d-ALAD activity and elevated FEP concentrations in petrol sniffers on admission further suggest a heavy burden of inorganic lead equivalent to occupationally exposed individual^.^^^^^ However, d-ALAD appeared to be activated during chelation therapy and this may be due to the effect of sulphydryl groups in BAL restoring enzyme a~tivity.…”