<p class="abstract">The salivary glands home of several tumoral pathologies, diversified by their locations and their histological types. Described as a rare malignant tumor of the accessory salivary glands, more so in the palatine bone; the diagnosis of Mucoepidermoid carcinoma (CME) remains difficult to evoke due to the uncommonness of the clinical signs and the insidious evolution. The purpose of this case report is to discuss the clinical manifestation, diagnosis, treatment and the follow-up plan of this case. A 39-year-old patient, with no prior pathological history, presents with a painless swelling on the palate evolving for 4 years causing swallowing difficulties without any other signs, several clinical, radiographic and histopathological investigations were carried out for excision of the lesion. Biopsy of the lesion confirmed the diagnosis as mucoepidermoid carcinoma of the palate, following which wide surgical excision with adjacent free margins was performed, the additional surgical treatment consisted of bilateral functional lymph node dissection of groups I, II and III. The follow-up of the patient shows a good improvement in the local condition in the 18 months, after 36 radiotherapy sessions and without signs of recurrence. On the control CT scan with placement of an obturator palatal prosthesis to improve the quality of life awaiting a palatal flap. This case report highlights the need for diagnosis and of an appropriate treatment plan in cases of malignant tumors, as this can lead to morbidity and mortality.</p>