Slow gallbladder emptying reverts to normal but small intestinal transit of a physiological meal remains slow in celiac patients during gluten‐free diet

Benini, Federica; Mora, Alessandra; Turini, Daniele; Bertolazzi, S.; Lotti, Francesco; Ricci, Chiara; Villanacci, Vincenzo; Barbara, Giovanni; Stanghellini, Vincenzo; Lanzini, Alberto

doi:10.1111/j.1365-2982.2011.01822.x

Cited by 20 publications

(23 citation statements)

References 34 publications

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“…The authors demonstrated that patients with CD and fat malabsorption tend to have a delayed mouth-cecum transit in spite of apparently normal gastric emptying and normal levels of insulin, GIP, CCC, neurotensin and PYY [12]. A delay in M-CTT in CD was also reported by Benini et al [29]. …”

Section: Gastrointestinal Motility Alterations In CD and Ncgsmentioning

confidence: 86%

“…A positive effect of the GFD on M-CTT was reported by some groups, but not confirmed by others [29]. In a study performed by Bassotti et al [31], motility alterations assessed by manometry persisted on those in whom CD was still active, despite the GFD.…”

Section: The Effect Of Gfd On Gut Motilitymentioning

confidence: 87%

“…Gastric motility and emptying in CD have been reported to be normal [12,33,34] or delayed [17,26,29,35]. The reason for the different findings could relate to different methods used to assess gastric emptying [17,35].…”

Section: Gastrointestinal Motility Alterations In CD and Ncgsmentioning

confidence: 99%

“…The major finding was that this abnormal colonic behavior was principally due to a subpopulation of untreated patients with very fast transit times (<18 h) [36]. Using the same methodology, Benini et al [29] measured colonic transit time in 19 CD patients and no differences in mean numbers of markers were observed. However, a limitation of the latest study is that colonic transit time was performed in only a subset of patients and healthy volunteers.…”

Section: Colonic Motility Alterations In CD and Ncgsmentioning

confidence: 99%

“…Benini et al [29] performed a study to assess gallbladder motility by ultrasonography, and found that gallbladder fasting volume and postprandial residual volume were significantly higher in CD patients than in controls. Fraquelli et al [39] measured gallbladder volume and plasma levels of cholecystokinin and somatostatin by ultrasonography and radioimmunoassay in a cohort of 10 celiac patients at diagnosis, after 18 months of GFD, and 10 HC.…”

Section: Gallbladder Motility Alterations In CD and Ncgsmentioning

confidence: 99%

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Motility Alterations in Celiac Disease and Non-Celiac Gluten Sensitivity

Sánchez

Berčík²,

Verdú³

2015

Dig Dis

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Regulation of gut motility is complex and involves neuromuscular, immune and environmental mechanisms. It is well established that patients with celiac disease (CD) often display gut dysmotility. Studies have shown the presence of disturbed esophageal motility, altered gastric emptying, and dysmotility of the small intestine, gallbladder and colon in untreated CD. Most of these motor abnormalities resolve after a strict gluten-free diet, suggesting that mechanisms related to the inflammatory condition and disease process are responsible for the motor dysfunction. Motility abnormalities are also a hallmark of functional bowel disorders such as irritable bowel syndrome (IBS), where it has been proposed as underlying mechanism for symptom generation (diarrhea, constipation, bloating). Non-celiac gluten sensitivity (NCGS) is a poorly defined entity, mostly self-diagnosed, that presents clinically with IBS symptoms in the absence of specific celiac markers. Patients with NCGS are believed to react symptomatically to wheat components, and some studies have proposed the presence of low-grade inflammation in these patients. There is little information regarding the functional characterization of these patients before and after a gluten-free diet. A study suggested the presence of altered gastrointestinal transit in NCGS patients who also have a high prevalence of nonspecific anti-gliadin antibodies. Results of an ongoing clinical study in NCGS patients with positive anti-gliadin antibodies before and after a gluten-free diet will be discussed. Elucidating the mechanisms for symptom generation in NCGS patients is important to find new therapeutic alternatives to the burden of imposing a strict gluten-free diet in patients who do not have CD.

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Section: Gastrointestinal Motility Alterations In CD and Ncgsmentioning

confidence: 86%

Section: The Effect Of Gfd On Gut Motilitymentioning

confidence: 87%