Slow Extraction Techniques at the Marburg Ion-Beam Therapy Centre

Krantz, Claude; Cee, R.; Faber, Fiona; Feldmeier, Eike; Fischer, Tobias; Galonska, M.; Haberer, Thomas; Kroeck, Benno; Peters, A.; Scheeler, U.; Scheloske, Stefan; Schömers, Christian; Weber, A.; Witt, Matthias

doi:10.18429/jacow-ipac2018-tupal036

Cited by 9 publications

(10 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extraction mechanism most often used in synchrotron ion beam therapy facilities is based around two methods: a slow resonant mechanism which is usually driven by a transverse excitation [RF knockout (RF-KO) ( 51 , 52 )] or a longitudinally slowly induced energy change [Betatron magnet ( 47 , 53 , 54 )]. For slow resonant extraction, the beam can be kept bunched throughout the extraction process, making re-acceleration (or deceleration) a delicate but feasible process.…”

Section: Limitations and Avenues For Improvementsmentioning

confidence: 99%

“…Although the process is not completely lossless, it requires only roughly ~100 ms (37,49) to change beam energy 2 . The extraction mechanism most often used in synchrotron ion beam therapy facilities is based around two methods: a slow resonant mechanism which is usually driven by a transverse excitation [RF knockout (RF-KO) (51,52)] or a longitudinally slowly induced energy change [Betatron magnet (47,53,54)].…”

Section: Synchrotronsmentioning

confidence: 99%

See 1 more Smart Citation

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

2021

View full text Add to dashboard Cite

The physical and clinical benefits of charged particle therapy (CPT) are well recognized. However, the availability of CPT and complete exploitation of dosimetric advantages are still limited by high facility costs and technological challenges. There are extensive ongoing efforts to improve upon these, which will lead to greater accessibility, superior delivery, and therefore better treatment outcomes. Yet, the issue of cost remains a primary hurdle as utility of CPT is largely driven by the affordability, complexity and performance of current technology. Modern delivery techniques are necessary but limited by extended treatment times. Several of these aspects can be addressed by developments in the beam delivery system (BDS) which determines the overall shaping and timing capabilities enabling high quality treatments. The energy layer switching time (ELST) is a limiting constraint of the BDS and a determinant of the beam delivery time (BDT), along with the accelerator and other factors. This review evaluates the delivery process in detail, presenting the limitations and developments for the BDS and related accelerator technology, toward decreasing the BDT. As extended BDT impacts motion and has dosimetric implications for treatment, we discuss avenues to minimize the ELST and overview the clinical benefits and feasibility of a large energy acceptance BDS. These developments support the possibility of advanced modalities and faster delivery for a greater range of treatment indications which could also further reduce costs. Further work to realize methodologies such as volumetric rescanning, FLASH, arc, multi-ion and online image guided therapies are discussed. In this review we examine how increased treatment efficiency and efficacy could be achieved with improvements in beam delivery and how this could lead to faster and higher quality treatments for the future of CPT.

show abstract

Section: Limitations and Avenues For Improvementsmentioning

confidence: 99%

Section: Synchrotronsmentioning

confidence: 99%

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

2021

View full text Add to dashboard Cite

show abstract

“…It is also worth noting that different "slow" extraction methods exist, like quadrupleresonance extraction, 67 the betatron core extraction, 69 and the RF-KO extraction. 68,70 In recent years a consensus has emerged that the RF-KO method is optimal for radiotherapy because the extraction intensity (particle rate) can be optimally modulated and controlled and hence allows an optimum scanning speed 67 and would, therefore, be the best option for FLASH irradiation with synchrotrons.…”

Section: Implementation Of Fl Ash Dose R Ates At C-ion Synchrotronsmentioning

confidence: 99%

“…The ion beam therapy facilities of Heidelberg and Marburg (HIT and MIT) are limited to <1 × 10 9 carbon ions per spill. 70,71 Recent tests for FLASH irradiations at HIT proved that spills of 5 × 10 8 carbon ions can be reliably extracted. The CNAO ion beam synchrotron in Italy-having a comparable ring diameter-can provide similar particle numbers per spill.…”

Section: Statement Of the Problem And Tg Chargesmentioning

confidence: 99%

FLASH radiotherapy with carbon ion beams

2021

View full text Add to dashboard Cite

show abstract

“…The extraction mechanism most often used in synchrotron ion beam therapy facilities is based around a slow resonant mechanism which is usually driven by a transverse excitation (RF knockout (RF-KO) [51,52]) or a longitudinally slowly induced energy change (Betatron magnet [47,53,54]). The former technique can keep the beam bunched throughout the extraction process, making re-acceleration (or deceleration) a delicate but feasible process.…”

Section: Synchrotronsmentioning

confidence: 99%

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Yap,

De Franco,

Sheehy

2021

Preprint

View full text Add to dashboard Cite

The physical and clinical benefits of charged particle therapy (CPT) are well recognised and recent developments have led to the rapid emergence of facilities, resulting in wider adoption worldwide. Nonetheless, the availability of CPT and complete exploitation of dosimetric advantages are still limited by high facility costs and technological challenges. There are extensive ongoing efforts to improve upon these, which will lead to greater accessibility, superior delivery, and therefore better treatment outcomes. The issue of cost however still remains a primary hurdle as the utility of CPT is largely driven by the affordability, complexity and performance of current technology. Several of these aspects can be addressed by developments to the beam delivery system (BDS) which determine the overall shaping and timing capabilities to provide high quality treatments. Modern delivery techniques are necessary but are limited by extended treatment times. The energy layer switching time (ELST) is a limiting constraint of the BDS and a determinant of the beam delivery time (BDT), along with the accelerator and other factors. This review evaluates the delivery process in detail, presenting the limitations and developments for the BDS and related accelerator technology, toward decreasing the BDT. As extended BDT impacts motion and has dosimetric implications for treatment, we discuss avenues to minimise the ELST and overview the clinical benefits and feasibility of a large energy acceptance BDS. These developments support the possibility of delivering advanced methodologies such as volumetric rescanning, FLASH and arc therapy and can further reduce costs given a faster delivery for a greater range of treatment indications. Further work to realise multi-ion, image guided and adaptive therapies is also discussed. In this review we examine how increased treatment efficiency and efficacy could be achieved with an improved BDS and how this could lead to faster and higher quality treatments for the future of CPT.

show abstract

Slow Extraction Techniques at the Marburg Ion-Beam Therapy Centre

Cited by 9 publications

References 3 publications

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

FLASH radiotherapy with carbon ion beams

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Contact Info

Product

Resources

About