Abstract:The mechanism underlying allostery in hemoglobin (Hb) is still not completely understood. Various models describing the action of allosteric effectors on Hb function have been published in the literature. It has also been reported that some allosteric effectors—such as chloride ions, inositol hexaphosphate, 2,3-diphospho-glycerate and bezafibrate—considerably lower the oxygen affinity of Hb. In this context, an important question is the extent to which these changes influence the conformational dynamics of the… Show more
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