Slow degrading hyaluronic acid hydrogel reinforced with cationized graphene nanosheets

Patil, Rahul; Kansara, Vrushti; Ray, Debes; Aswal, Vinod K.; Jha, Prafulla K.; Bahadur, Pratap; Tiwari, Sanjay

doi:10.1016/j.ijbiomac.2019.08.243

Cited by 21 publications

(9 citation statements)

References 44 publications

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“…In general, Schiff bases are characterized by poor degradation, but aldehyde-hydrazide-based hydrogels form a subclass of Schiff’s base called hydrazone bond which presents excellent ability of hydrolysis in aqueous environments [ 18 ]. Therefore, to enhance the stability of the material against degradation, some researchers have reinforced the hydrogel with materials such as graphene or cellulose, obtaining satisfactory results in vitro [ 11 , 19 , 42 , 43 ]. However, we prefer not to use these reinforcements because it is still unknown whether they could generate foreign body reactions at the periapical zone as the classical cases reported by Koppang and Nair [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Injectable Hyaluronic Acid-Based Hydrogels for Endodontic Tissue Regeneration

et al. 2021

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Dental pulp tissue engineering (TE) endeavors to regenerate dentin/pulp complex by combining a suitable supporting matrix, stem cells, and biochemical stimuli. Such procedures foresee a matrix that can be easily introduced into the root canal system (RCS) and tightly adhere to dentin walls to assure the dentin surface’s proper colonization with progenitor cells capable of restoring the dentin/pulp complex. Herein was investigated an injectable self-setting hyaluronic acid-based (HA) hydrogel system, formed by aldehyde-modified (a-HA) with hydrazide-modified (ADH), enriched with platelet lysate (PL), for endodontic regeneration. The hydrogels’ working (wT) and setting (sT) times, the adhesion to the dentine walls, the hydrogel’s microstructure, and the delivery of human dental pulp cells (DPCs) were studied in vitro. Hydrogels incorporating PL showed a suitable wT and sT and a porous microstructure. The tensile tests showed that the breaking point occurs after 4.3106 ± 1.8677 mm deformation, while in the indentation test after 1.4056 ± 0.3065 mm deformation. Both breaking points occur in the hydrogel extension. The HA/PL hydrogels exhibited supportive properties and promoted cell migration toward dentin surfaces in vitro. Overall, these results support using PL-laden HA injectable hydrogels (HA/PL) as a biomaterial for DPCs encapsulation, thereby displaying great clinical potential towards endodontic regenerative therapies.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Injectable Hyaluronic Acid-Based Hydrogels for Endodontic Tissue Regeneration

et al. 2021

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“…In general, Schiff bases are characterized by poor degradation, but aldehyde-hydrazide-based hydrogels form a subclass of Schiff's base called hydrazone bond which presents excellent ability of hydrolysis in aqueous environments [15]. Therefore, to enhance the stability of the material against degradation, some researchers have reinforced the hydrogel with materials such as graphene or cellulose, obtaining satisfactory results in vitro [12,16,38,39]. However, we prefer not to use these reinforcements because it is still unknown whether they could generate foreign body reactions at the periapical zone as the classical cases reported by Koppang and Nair [40,41].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Injectable Hyaluronic Acid-Based Hydrogels for Endodontic Tissue Regeneration

Astudillo-Ortiz¹,

Babo²,

Reis³

et al. 2021

Preprint

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Dental pulp tissue engineering (TE) quests to regenerate dentin/pulp complex by combining a suitable supporting matrix, stem cells, and biochemical stimuli. Such procedures foresee a matrix that can be easily introduced into the root canal system (RCS) and tightly adhere to dentin walls to assure the dentin surface's proper colonization with progenitor cells capable of restoring the dentin/pulp complex. Herein was investigated an injectable self-setting hyaluronic acid-based (HA) hydrogel system, formed by aldehyde-modified (a-HA) with hydrazide-modified (ADH), enriched with platelet lysate (PL), for endodontic regeneration. The hydrogels' working (wT) and setting (sT) times, the adhesion to the dentine walls, the hydrogel's microstructure, and the delivery of human Dental Pulp Cells (DPCs) were studied in vitro. Hydrogels incorporating PL showed a suitable wT and sT and a porous microstructure. The tensile tests showed that the breaking point occurs after 4.13 mm deformation. While in the indentation test after 1.3 mm deformation. Both breaking points occur in the hydrogel extension. The HA/PL hydrogels exhibited supportive properties and promoted cell migration toward dentin surfaces in vitro. Overall, these results support using PL-laden HA injectable hydrogels (HA/PL) as a biomaterial for DPCs encapsulation, thereby displaying great clinical potential towards endodontic regenerative therapies.

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“…GO sheets were synthesized from graphite using modified Hummers method described previously 3,19 . Mixed micelles (P103-DTAB) were prepared by adding different concentration of DTAB (0.1-20 mM) to 1% solution of P103.…”

Section: Methods and Characterizationsmentioning

confidence: 99%

Adsorption of P103 Nanoaggregates on Graphene Oxide Nanosheets: Role of Electrostatic Forces in Improving Nanosheet Dispersion

et al. 2021

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Highlights1. P103 micelles improve aqueous dispersibility of graphene sheets through formation of fractal aggregates.2. Affinity of aggregates can be improved by imparting positive surface charge to the micelles.3. Surface charge was induced in P103 micelles by incorporating DTAB, a cationic surfactant.4. Mixed micelles triggered the formation of small-sized building blocks and improved the dispersity of sheets.

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Slow degrading hyaluronic acid hydrogel reinforced with cationized graphene nanosheets

Cited by 21 publications

References 44 publications

Evaluation of Injectable Hyaluronic Acid-Based Hydrogels for Endodontic Tissue Regeneration

Evaluation of Injectable Hyaluronic Acid-Based Hydrogels for Endodontic Tissue Regeneration

Evaluation of Injectable Hyaluronic Acid-Based Hydrogels for Endodontic Tissue Regeneration

Adsorption of P103 Nanoaggregates on Graphene Oxide Nanosheets: Role of Electrostatic Forces in Improving Nanosheet Dispersion

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