Slow Cortical Potentials in Migraine Families

Abstract

Amplitude and habituation of event-related potentials are abnormal in migraine. We investigated 43 migraine and 41 healthy families to evaluate the influences of age, sex and familial contribution on the variance of amplitude and habituation of the contingent negative variation (CNV). Analysis of individual differences in relation to the CNV habituation was performed. The study demonstrated that habituation of the early CNV component characterizes migraine considerably better than the CNV amplitudes. Habituation, however, is strongly influenced by age. Migraine adults and children generally showed reduced habituation. Surprisingly, more than 30% of the healthy adults demonstrated a marked loss of habituation. The reduced CNV habituation represented a high sensitivity but low specificity to migraine, especially in children. CNV amplitude and habituation parameters revealed a considerable familial contribution associated with migraine. No familial influence on either morphology or habituation of the CNV in healthy families or between healthy members of migraine families was observed. The low specificity and familial transmission of CNV parameters in members of migraine families suggest that increased amplitudes and reduced habituation of CNV do not constitute a primary risk factor for migraine, but rather represent a predisposition. Genetic components probably affect variation of the CNV amplitude and habituation.

Neurobiology in primary headaches

“…Reduced habituation of event-related potentials (ERPs) and enhanced contigent negative variation (CNV) appear to be a unique characteristic of migraine with and without aura [141,175]. Thus, there is evidence of cortical hyperexcitability and lack of habituation to repetitive stimuli in the migraine brain.…”

Deep Belief Networks Based Brain Activity Classification Using EEG from Slow Cortical Potentials in Stroke

“…Kotchoubey et al analysed the influencing factors in epilepsy using twenty sessions SCP training and detected the positive trials are more important than the negative trials [7,8]. Strehl et al used functional magnetic resonance imaging and the BOLD signal in the SCP and reduced epileptic seizure frequency [17], Siniatchkin et al evaluated the analysis of individual differences in migraine and experienced the negative trials from the SCP differed significantly between the individual habitat [9], Schneider et al determined the efficiency of the SCP training with self-regulation task utilizing biofeedback and instrumental conditioning in psychiatric patients with alcohol dependency [10], Hinterberger et al developed a tough translation device for ALS patients using the SCP trials [3], Pham et al developed an auditory braincomputer stimuli for paralysed patients using the SCP and discussed auditory stimuli characteristics may have to be adapted to optimize brain-computer interface performances [5]. The studies based on cognitive functions, motor performance of the brain and many neurological disorders in literature are indicated the efficiency and the importance of the SCP training and classification of the brain activities from the SCP training such as negativity trials or positivity trials in stroke patients.…”

“…Ergenoglu et al worked on determining the relationship between SCP and P300 amplitude [12], Khader et al analysed the relations between the SCP and Blood-oxygen-level dependent (BOLD) signal changes [16], Devrim et al investigated the detection of visual stimuli at sensory threshold using the SCP [6], Kotchoubey et al used the SCP training in the research on epilepsy with analysis of influencing factors [7,8]. Strehl et al used functional magnetic resonance imaging and the BOLD signal in the SCP to reduce epileptic seizure frequency [17], Siniatchkin et al evaluated the analysis of migraine [9], Schneider et al determined the efficiency of the SCP training in psychiatric patients with alcohol dependency [10], Cosch et al associated the SCP with the eventrelated potentials such as object, spatial, and verbal information [4], Hinterberger et al suggested a robust and steady communication method between computer and brain for amyotrophic lateral sclerosis patients using the SCP and studied on developing a tough translation device [3], Pham et al developed an auditory brain-computer stimuli for paralysed patients using the SCP [5]. Stroke is a brain disorder that causes when the blood supply of brain cells is either cut off or reduced and the cells began to die.…”

Neurophysiological Determinants of Tic Severity in Children with Chronic Motor Tic Disorder

“…b, where a is the slope of habituation and b the intercept of linear regression; Petrinovich and Widaman 1984). Previous studies demonstrated that the habituation is a primary characteristic of the iCNV (Birbaumer et al 1990;Siniatchkin et al 2000). Therefore, only habituation of the iCNV component was calculated for this study.…”