Abstract:Slow conformational changes are often directly linked to protein function. It is however less clear how such processes may perturb the overall folding stability of a protein. We previously found that the stabilizing double mutant L49I/I57V in the small protein chymotrypsin inhibitor 2 from barley led to distributed increased nano second and faster dynamics. Here we asked what effect this mutant and the two individual mutants L49I and I57V have on the slow conformational dynamics of CI2. We used 15N CPMG spin r… Show more
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