Slovak Trial on Cardiovascular Risk Reduction Following National Guidelines with CaDUET® (The STRONG DUET Study)

Abstract

Single-pill amlodipine/atorvastatin was associated with significant improvements in BP, LDL-C target attainment, and 10-year CV risk in patients with uncontrolled hypertension in Slovakia. The treatment was well-tolerated and safe. Use of single-pill amlodipine/atorvastatin in high CV-risk countries could lead to significant improvements in CV risk management.

<p>Efficacy of a fixed dose combination of irbesartan and atorvastatin (Rovelito^&reg;) in Korean adults with hypertension and hypercholesterolemia</p>

“…The study duration was only 3 months, which was rather short for judging the study drug’s protective effects on the cardiovascular system. Previous open label, non-comparative studies that evaluated the efficacy and safety of an FDC of amlodipine and atorvastatin for the treatment of patients with HTN and hypercholesterolemia, were conducted for 12–14 weeks 16,23. Furthermore, a previous placebo-controlled study showed that an FDC of irbesartan and atorvastatin provided effective, safe treatment to which patients with HTN and hypercholesterolemia showed good adherence, as the treatment duration was only 8 weeks 24.…”