SLN enriched hydrogels for dermal application: Full factorial design study to estimate the relationship between composition and mechanical properties

Amasya, Gülin; Inal, Ozge; Sengel-Türk, Ceyda Tuba

doi:10.1016/j.chemphyslip.2020.104889

Cited by 22 publications

(9 citation statements)

References 32 publications

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“…TA.XT Plus Texture Analyzer was utilized in compression mode with a 5 kg load cell and a trigger force of 0.05 N to measure the maximum peak force versus time andto calculate the firmness value of the semi-solid lipid nanoparticle formulations. It should be noted that a lower hardness value is desired in order to remove the semi-solid product from the container and to spread it to the skin surface easily [24][25]. As presented in Table 2; SemiSLN-2 had the highest firmness value of 2.695 N, while the lowest firmness value of 1.137 N was measured for semiSLN-1.…”

Section: Resultsmentioning

confidence: 98%

A novel formulation strategy for skin occlusion: Semi-solid lipid nanoparticles

AMASYA¹

2021

jrp

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Lipid nanoparticles (SLNs and NLCs) have possessed many advantages as versatile and innovative carriers to achieve better quality and highly effective skin-care cosmeceuticals. While they protect the water content of the epidermis by increasing skin occlusion, maintain the smoothness and elasticity of the skin, enhance the efficacy of the active substance by penetrating into the deep layers of the skin. Semi-solid lipid nanoparticles, which are the latest generation of lipid nanoparticles containing high amount of lipids compared to SLNs and NLCs are promising systems as nano-cosmeceuticals due to their semi-solid consistency and colloidal particle size. In this study, semi-solid lipid nanoparticles in NLC form were obtained by using different vegetable oils that possess positive effects in the dermal application. Then, the main in vitro physicochemical characteristics of the formulations that affect skin hydration like size, surface charge, and occlusive properties were investigated. Overall results suggested that, while vegetable oil loaded semi-solid lipid nanoparticles were obtained, colloidal size and semi-solid consistency could be maintained. On the other hand, all formulations had acceptable firmness values for customer use despite the high lipid content of the system, and enhanced skin hydration with the help of both vegetable oils and lipid nanoparticles were achieved.

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Section: Resultsmentioning

confidence: 98%

A novel formulation strategy for skin occlusion: Semi-solid lipid nanoparticles

AMASYA¹

2021

jrp

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“…However, comparing GC and GH, their performance on skin penetration of TH-NLC was similar, providing more suitable results. Due to the fact that carbomer gels (GC-TH-NLC) show to increased skin TH-NLC retention and have the advantages of ease of spreading, wide viscosity intervals, good organoleptic characteristics, and very low concentrations needed, 58 , 59 this gel was chosen for further penetration studies. Therefore, carbomer gel was also used to incorporate TH in its free form, and this was compared to aqueous free TH and TH-NLC ( Figure 6B ).…”

Section: Resultsmentioning

confidence: 99%

Gel-Dispersed Nanostructured Lipid Carriers Loading Thymol Designed for Dermal Pathologies

Folle,

Marqués,

Díaz-Garrido

et al. 2024

IJN

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Purpose Acne vulgaris is one of the most prevalent dermal disorders affecting skin health and appearance. To date, there is no effective cure for this pathology, and the majority of marketed formulations eliminate both healthy and pathological microbiota. Therefore, hereby we propose the encapsulation of an antimicrobial natural compound (thymol) loaded into lipid nanostructured systems to be topically used against acne. Methods To address this issue, nanostructured lipid carriers (NLC) capable of encapsulating thymol, a natural compound used for the treatment of acne vulgaris, were developed either using ultrasonication probe or high-pressure homogenization and optimized using 2 2 -star factorial design by analyzing the effect of NLC composition on their physicochemical parameters. These NLC were optimized using a design of experiments approach and were characterized using different physicochemical techniques. Moreover, short-term stability and cell viability using HaCat cells were assessed. Antimicrobial efficacy of the developed NLC was assessed in vitro and ex vivo. Results NLC encapsulating thymol were developed and optimized and demonstrated a prolonged thymol release. The formulation was dispersed in gels and a screening of several gels was carried out by studying their rheological properties and their skin retention abilities. From them, carbomer demonstrated the capacity to be highly retained in skin tissues, specifically in the epidermis and dermis layers. Moreover, antimicrobial assays against healthy and pathological skin pathogens demonstrated the therapeutic efficacy of thymol-loaded NLC gelling systems since NLC are more efficient in slowly reducing C. acnes viability, but they possess lower antimicrobial activity against S. epidermidis , compared to free thymol. Conclusion Thymol was successfully loaded into NLC and dispersed in gelling systems, demonstrating that it is a suitable candidate for topical administration against acne vulgaris by eradicating pathogenic bacteria while preserving the healthy skin microbiome.

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“…Studies on mechanical features of semi-solid and disperse systems are important to mimic the real situations such as ease of removal from the container, spreading onto the skin; therefore, patient acceptability and ease of use are highly influenced by the mechanical parameters of the formulations. Texture profile analysis (TPA) is a suitable method for determining the mechanical properties such as hardness, compressibility, cohesiveness, elasticity and adhesiveness of emulgels [29,30]. It is also useful tool in providing information about batch-to-batch uniformity, quality and stability of formulations [31].…”

Section: Evaluation Of the Mechanical Properties Of Emulgelsmentioning

confidence: 99%

“…In TPA analysis, hardness and compressibility two parameters directly obtained from force-time curves and are used for interpreting the ease of removing the product from the container or skin application of the product. Hardness defines as the maximum peak force during the first compression cycle whereas compressibility defines the work required to deform the product during the first compression of probe [30,32].…”

Section: Evaluation Of the Mechanical Properties Of Emulgelsmentioning

confidence: 99%

“…It is related with the reconstruction of the product after deformation in time. The decrease in the numerical value of elasticity shows the increase in the elasticity of gel, which indicates greater product elasticity and therefore better skin retention [30,32,33]. The results of TPA analysis are given in Table 2.…”

Section: Evaluation Of the Mechanical Properties Of Emulgelsmentioning

confidence: 99%

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In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

ERGİN¹,

Inal²,

BARAKAT³

2023

jrp

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Curcumin has been used in many diseases due to its high therapeutical potential in recent years. Although curcumin is a frequently used natural polyphenolic compound products, its low solubility and poor permeability limits the dermal efficacy of curcumin. Emulgels are a new generation of semi-solid formulations that combine the advantages of both emulsions and gels. The biggest limitation of emulsions is surfactant related irritation problems caused by the use of high amount of surfactants. In this study, it was aimed to increase the skin permeability of curcumin by developing surfactant-free emulgel formulations. In the study, emulgels were developed by Carbopol 940 gels as the aqueous phase, olive oil and curcumin methanol solution as the oil phase. No surfactant was used additionally to show the stabilizing effect of Carbopol in emulgels. The emulgel formulations were subjected to physicochemical characterization by means of organoleptic properties, pH, rheological and mechanical properties. Mechanical properties were carried out by texture profile analyzes to determine the structure related properties such as hardness, compressibility, adhesiveness, cohesiveness and elasticity. The spreadability of the formulations was also determined with Texture Analyzer. Obtained emulgels showed good rheological, mechanical and spreadability properties. The transdermal permeation of the chosen emulgel was studied ex vivo against hydrogel prepared with the same amount of Carbopol. The emulgel formulation significantly increased transdermal permeation compared to the hydrogel. This emulgel formulation successfully passed from stress tests. As a conclusion, the novel surfactant-free emulgel formulation was successfully developed to increase curcumin permeation through the rat skin.

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SLN enriched hydrogels for dermal application: Full factorial design study to estimate the relationship between composition and mechanical properties

Cited by 22 publications

References 32 publications

A novel formulation strategy for skin occlusion: Semi-solid lipid nanoparticles

A novel formulation strategy for skin occlusion: Semi-solid lipid nanoparticles

Gel-Dispersed Nanostructured Lipid Carriers Loading Thymol Designed for Dermal Pathologies

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

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