Abstract:Background Distant metastasis remained the major cause of mortality in nasopharyngeal carcinoma (NPC) receiving radiotherapy despite favorable locoregional control in the past decades. Tumor microenvironment plays a critical role in tumor progression by secreting factors that regulate cancer cell metastasis. We explored the role of secreted protein Slit2 in NPC metastasis and the underlying mechanisms. Methods Colony formation assay were determined the opitimal dose. Using real-time PCR, western blotting, and … Show more
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