“Slip-slidin’ away”:

Brooker, Jewel Spears

doi:10.2307/j.ctvhn0cz2.11

Cited by 2 publications

(3 citation statements)

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“…Overdose response after naloxone administration 29 2016 administration by community and lay users, service staff, police and other non-healthcare professionals [52,56].…”

Section: Reviewmentioning

confidence: 99%

Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review

Moustaqim‐Barrette

Dhillon

et al. 2021

BMC Public Health

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Background Opioid related overdoses and overdose deaths continue to constitute an urgent public health crisis. The implementation of naloxone programs, such as ‘take-home naloxone’ (THN), has emerged as a key intervention in reducing opioid overdose deaths. These programs aim to train individuals at risk of witnessing or experiencing an opioid overdose to recognize an opioid overdose and respond with naloxone. Naloxone effectively reverses opioid overdoses on a physiological level; however, there are outstanding questions on community THN program effectiveness (adverse events, dosing requirements, dose-response between routes of administration) and implementation (accessibility, availability, and affordability). The objective of this scoping review is to identify existing systematic reviews and best practice guidelines relevant to clinical and operational guidance on the distribution of THN. Methods Using the Arksey & O’Malley framework for scoping reviews, we searched both academic literature and grey literature databases using keywords (Naloxone) AND (Overdose) AND (Guideline OR Review OR Recommendation OR Toolkit). Only documents which had a structured review of evidence and/or provided summaries or recommendations based on evidence were included (systematic reviews, meta-analyses, scoping reviews, short-cut or rapid reviews, practice/clinical guidelines, and reports). Data were extracted from selected evidence in two key areas: (1) study identifiers; and (2) methodological characteristics. Results A total of 47 articles met inclusion criteria: 20 systematic reviews; 10 grey literature articles; 8 short-cut or rapid reviews; 4 scoping reviews; and 5 other review types (e.g. mapping review and comprehensive reviews). The most common subject themes were: naloxone effectiveness, safety, provision feasibility/acceptability of naloxone distribution, dosing and routes of administration, overdose response after naloxone administration, cost-effectiveness, naloxone training and education, and recommendations for policy, practice and gaps in knowledge. Conclusions Several recent systematic reviews address the effectiveness of take-home naloxone programs, naloxone dosing/route of administration, and naloxone provision models. Gaps remain in the evidence around evaluating cost-effectiveness, training parameters and strategies, and adverse events following naloxone administration. As THN programs continue to expand in response to opioid overdose deaths, this review will contribute to understanding the evidence base for policy and THN program development and expansion.

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“…Overdose response after naloxone administration 29 2016 administration by community and lay users, service staff, police and other non-healthcare professionals [52,56].…”

Section: Reviewmentioning

confidence: 99%

Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review

Moustaqim‐Barrette

Dhillon

et al. 2021

BMC Public Health

View full text Add to dashboard Cite

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“…Gunn et al assessed distribution of naloxone from emergency departments (40), and Behar et al assessed acceptability and feasibility of naloxone prescribing to patients in primary care settings (41). One mapping review assessed evidence on THN distribution from correctional facilities to identify further research needs (42), and two rapid reviews assessed attitudes and experiences related to naloxone administration by community and lay users, service staff, police and other non-healthcare professionals (43,44).…”

Section: Provision Feasibility and Acceptability Of Naloxone Distrimentioning

confidence: 99%

“…Overdose response after naloxone administration Provision, feasibility and acceptability of naloxone distribution 13 (27.7%) (30,(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) Effectiveness of naloxone and take-home naloxone (THN) for opioid overdose reversal 10 (21.3%) (10,12,(27)(28)(29)(32)(33)(34)(35)31,36) Overdose response after naloxone administration 6 (12.8%) (51,65,66,72,73,75) Naloxone training and education 6 (12.8%) (12,29,33,36,38,45) Recommendations for policy, practice, and gaps in knowledge 4 (8.5%) (67)(68)(69)(70) Naloxone safety (harm and adverse events related to naloxone administration)…”

Section: Reviewmentioning

confidence: 99%

Take-Home Naloxone Programs for Suspected Opioid Overdose in Community Settings: A Scoping Umbrella Review

Moustaqim‐Barrette

Dhillon

et al. 2021

Preprint

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Background: Opioid related overdoses and overdose deaths continue to constitute an urgent public health crisis. The implementation of naloxone programs, such as ‘take-home naloxone’ (THN), has emerged as a key intervention in reducing opioid overdose deaths. These programs aim to train individuals at risk of witnessing or experiencing an opioid overdose to recognize an opioid overdose and respond with naloxone. Naloxone effectively reverses opioid overdoses on a biological level; however, there are outstanding questions on community THN program effectiveness (adverse events, dosing requirements, dose-response between routes of administration) and implementation (accessibility, availability, and affordability). The objective of this scoping review is to identify existing systematic reviews and best practice guidelines relevant to clinical and operational guidance on the distribution of THN.Methods: Using the Arksey & O’Malley framework for scoping reviews, we searched both academic literature and grey literature databases using keywords (Naloxone) AND (Overdose) AND (Guideline OR Review OR Recommendation OR Toolkit). Only documents which had a structured review of evidence and/or provided summaries or recommendations based on evidence were included (systematic reviews, meta-analyses, scoping reviews, short-cut or rapid reviews, practice/clinical guidelines, and reports). Data were extracted from selected evidence in two key areas: (1) study identifiers; and (2) methodological characteristics. Results: A total of 47 articles met inclusion criteria: 20 systematic review; 10 grey literature articles; 8 short-cut or rapid reviews; 4 scoping reviews; and 5 other review types (e.g. mapping review and comprehensive reviews). The most common subject themes were: naloxone effectiveness, safety, provision feasibility/acceptability of naloxone distribution, dosing and routes of administration, overdose response after naloxone administration, cost-effectiveness, naloxone training and education, and recommendations for policy, practice and gaps in knowledge. Conclusions: Several recent systematic reviews address the effectiveness of take-home naloxone programs, naloxone dosing/route of administration, and naloxone provision models. Gaps remain in the evidence around evaluating cost-effectiveness, training parameters and strategies, and adverse events following naloxone administration. As THN programs continue to expand in response to opioid overdose deaths, this review will contribute to understanding the evidence 60 base for policy and THN program development and expansion.

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“Slip-slidin’ away”:

Cited by 2 publications

References 0 publications

Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review

Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review

Take-Home Naloxone Programs for Suspected Opioid Overdose in Community Settings: A Scoping Umbrella Review

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