Forced convective laminar flow of different types of nanofluids such as Al 2 O 3 , CuO, SiO 2 , and ZnO, with different nanoparticle size 25, 45, 65, and 80 nm, and different volume fractions which ranged from 1% to 4% using ethylene glycol as base fluids were used. A three-dimensional microtube (MT) with 0.05 cm diameter and 10 cm in length with different values of heat fluxes at the wall is numerically investigated. This investigation covers Reynolds number (Re) in the range of 80 to 160. The results have shown that SiO 2 -EG nanofluid has the highest Nusselt number (Nu), followed by ZnO-EG, CuO-EG, Al 2 O 3 -EG, and finally pure EG.