SlimQuickTM-Associated Hepatotoxicity Resulting in Fulminant Liver Failure and Orthotopic Liver Transplantation

Whitsett, Maureen; Marzio, Dina Halegoua-De; Rossi, Simona

doi:10.14309/crj.2014.59

Cited by 17 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 Two additional cases of suspected hepatotoxicity specifically linked to SLIMQUICK ® has been reported. 22,23 The clinical features of those cases were similar to those described in this current report as summarized in Table 2.…”

Section: Discussion (4)supporting

confidence: 80%

Risk of Liver Injury Associated with Green Tea Extract in SLIMQUICK® Weight Loss Products: Results from the DILIN Prospective Study

et al. 2016

Self Cite

View full text Add to dashboard Cite

Introduction Herbal and dietary supplements (HDS) have been increasingly recognized as a cause for acute liver injury1, 2. HDS products frequently contain numerous ingredients, and are marketed under various product names. A perusal of marketed weight loss products indicates that green tea extract is a common ingredient in many. We aimed to describe the course and outcome of six patients who developed liver injury attributed to SLIMQUICK® weight loss products. Methods Patients with suspected drug induced liver injury were enrolled in a prospective study of the Drug-Induced Liver Injury Network (DILIN) and causality was assessed by a panel of hepatologists. During the period under study, 6 of 1091 cases of liver injury were attributed to a SLIMQUICK® product and were assigned causality scores of probable, highly likely, or definite. Results Six cases of acute liver injury attributed to SLIMQUICK® products were enrolled in the DILIN prospective study between 2007 and 2011. All were women aged 22 to 58 years. Two had a normal body weight and four were mildly obese (body mass index 22.9 to 32.2 kg/m2). All were taking SLIMQUICK® products for weight loss and no patient reported prior use. Laboratory tests revealed a hepatocellular pattern of injury, with initial alanine aminotransferase (ALT) levels above 1000 U/L in all but one patient. Three patients were hospitalized and one underwent successful liver transplantation. No patients died of liver injury. GTE and/or its component catechins were listed among the ingredients for 5 of the 6 products. Conclusions SLIMQUICK® products can lead to severe acute hepatocellular liver injury, which may result in transplantation. Given the frequency of GTE as a component in weight loss products, this ingredient should be studied further as a possible cause for liver injury.

show abstract

Section: Discussion (4)supporting

confidence: 80%

Risk of Liver Injury Associated with Green Tea Extract in SLIMQUICK® Weight Loss Products: Results from the DILIN Prospective Study

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some manufacturers recommend intakes over 100-times higher than those currently associated with a Western diet ( 110 ). In some cases, supplementation trials of antioxidants have been associated with adverse effects, including increased mortality or stroke in some studies ( 112 – 115 ). Concerns regarding heterogeneous effects in subpopulations and interactions with medications also arise with the promotion of polyphenol consumption at levels far above natural occurrence ( 114 ).…”

Section: Implications For Food Systems and Policymentioning

confidence: 99%

The Role of Polyphenols in Human Health and Food Systems: A Mini-Review

et al. 2018

View full text Add to dashboard Cite

This narrative mini- review summarizes current knowledge of the role of polyphenols in health outcomes—and non-communicable diseases specifically—and discusses the implications of this evidence for public health, and for future directions for public health practice, policy, and research. The publications cited originate mainly from animal models and feeding experiments, as well as human cohort and case-control studies. Hypothesized protective effects of polyphenols in acute and chronic diseases, including obesity, neurodegenerative diseases, type 2 diabetes, and cardiovascular diseases, are evaluated. Potential harmful effects of some polyphenols are also considered, counterbalanced with the limited evidence of harm in the research literature. Recent international governmental regulations are discussed, as the safety and health claims of only a few specific polyphenolic compounds have been officially sanctioned. The implications of food processing on the bioavailability of polyphenols are also assessed, in addition to the health claims and marketing of polyphenols as a functional food. Finally, this mini-review asserts the need for increased regulation and guidelines for polyphenol consumption and supplementation in order to ensure consumers remain safe and informed about polyphenols.

show abstract

“…In fact, some dietary supplements contain concentrations of polyphenols 100 times more elevated than those related to a western diet [261]. In a number of studies, administration of antioxidants has caused severe side effects such as mortality or stroke [262][263][264][265]. In this context, the possible interaction between polyphenols and drugs requires more intensive studies to understand the existence of synergism or neutralization in relation to their therapeutic activity.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

Magrone

Russo

et al. 2019

Antioxidants

View full text Add to dashboard Cite

In this review, special emphasis will be placed on red grape polyphenols for their antioxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of proinflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols will be illustrated with special reference to the activation of T regulatory cells which support a tolerogenic pathway at intestinal level. Additionally, the effects of red grape polyphenols will be analyzed in obesity, as a low-grade systemic inflammation. Also, possible modifications of inflammatory bowel disease biomarkers and clinical course have been studied upon polyphenol administration, either in animal models or in clinical trials. Moreover, the ability of polyphenols to cross the blood–brain barrier has been exploited to investigate their neuroprotective properties. In cancer, polyphenols seem to exert several beneficial effects, even if conflicting data are reported about their influence on T regulatory cells. Finally, the effects of polyphenols have been evaluated in experimental models of allergy and autoimmune diseases. Conclusively, red grape polyphenols are endowed with a great antioxidant and anti-inflammatory potential but some issues, such as polyphenol bioavailability, activity of metabolites, and interaction with microbiota, deserve deeper studies.

show abstract

SlimQuickTM-Associated Hepatotoxicity Resulting in Fulminant Liver Failure and Orthotopic Liver Transplantation

Cited by 17 publications

References 15 publications

Risk of Liver Injury Associated with Green Tea Extract in SLIMQUICK® Weight Loss Products: Results from the DILIN Prospective Study

Risk of Liver Injury Associated with Green Tea Extract in SLIMQUICK® Weight Loss Products: Results from the DILIN Prospective Study

The Role of Polyphenols in Human Health and Food Systems: A Mini-Review

Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

Contact Info

Product

Resources

About