Slim Body Weight Is Highly Associated With Enhanced Lipoprotein Functionality, Higher HDL-C, and Large HDL Particle Size in Young Women

Abstract

There has been no information about the correlations between body weight distribution and lipoprotein metabolism in terms of high-density lipoproteins-cholesterol (HDL-C) and cholesteryl ester transfer protein (CETP). In this study, we analyzed the quantity and quality of HDL correlations in young women (21.5 ± 1.2-years-old) with a slim (n = 21, 46.2 ± 3.8 kg) or plump (n = 30, 54.6 ± 4.4 kg) body weight. Body weight was inversely correlated with the percentage of HDL-C in total cholesterol (TC). The plump group showed 40% higher body fat (26 ± 3 %) and 86% more visceral fat mass (VFM, 1.3 ± 0.3 kg) than the slim group, which showed 18 ± 2% body fat and 0.7 ± 0.2 kg of VFM. Additionally, the plump group showed 20% higher TC, 58% higher triglyceride (TG), and 12% lower HDL-C levels in serum. The slim group showed 34% higher apoA-I but 15% lower CETP content in serum compared to the plump group. The slim group showed a 13% increase in particle size and 1.9-fold increase in particle number with enhanced cholesterol efflux activity. Although the plump group was within a normal body mass index (BMI) range, its lipid profile and lipoprotein properties were distinctly different from those of the slim group in terms of CETP mass and activity, HDL functionality, and HDL particle size.

Prevention and Early Detection of Metabolic Syndrome in Household Community, Surabaya

“…In this program, we found a significant positive correlation between body weight and abdominal circumference, significant inverse correlations between body weight and HDL, between abdominal circumference and HDL, and between TG and HDL. This was in line with previous studies showing significant positive correlation between body weight and abdominal circumference 12 , significant negative correlation between body weight and HDL 13 , between abdominal circumference and HDL 14 , and between TG and HDL 15 . This program had contribution for the community to reduce the incidence of metabolic syndrome in Indonesia, especially in urban household community.…”

Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population

“…A study involving 21 morbidly obese female participants (BMI > 40 kg/m 2 ) [68] who underwent a weight loss procedure concluded that weight loss was associated with a marked decrease in CETP mass and activity. Another study involving 51 normal weight individuals [70] also reported that participants with a body weight of around 46 kg had 15% lower serum CETP compared to those with a body weight of about 55 kg. However, an anti-adipogenic effect of CETP in the presence of apolipoprotein CIII (apoCIII) was reported by an animal study involving CETP and apoCIII transgenic mice [71], where obesity induced by a high-fat diet was reversed by the expression of CETP.…”

“…This study [58], which consisted of 199 overweight/obese Spanish adolescents and involved a weight loss intervention, showed that each minor allele of CETP SNP rs1800777 was associated with a −1.4 kg decrease in body weight after 10 weeks (p = 1.5 × 10 −4 ). Studies examining CETP and obesity have mainly focused on the impact of body weight on CETP mass and activity [68][69][70]. A study involving 21 morbidly obese female participants (BMI > 40 kg/m 2 ) [68] who underwent a weight loss procedure concluded that weight loss was associated with a marked decrease in CETP mass and activity.…”

Association of Lipid Profile with Body Mass Index in Public Employees in Halabja City, Kurdistan Region of Iraq

“…Slim body weight is very dependent on the amount of HDL-C in the body. There is an inverse relationship between BMI and the concentration of HDL-C (Park et al, 2018).…”