Background: Mini-gastric bypass (MGB) surgery is a successful and secure method for losing weight. It provides lasting weight loss with the possibility of revision or reversal. The procedure has potential benefits such as reduced surgery duration and enhanced patient contentment. Nevertheless, there are ongoing worries about its anatomical structure and metabolic consequences. Objectives: This systematic review aims to evaluate the safety and efficacy of MGB surgery. It assesses postoperative complications, adverse events, weight loss outcomes, and resolution of comorbidities. The review provides guidance for clinicians, researchers, and patients in their decision-making process. Methods: The study design followed the guidelines for meta-analyses of interventional studies. The researchers conducted a thorough investigation by exploring five scholarly databases, including PubMed, Scopus, Google scholar, and Web of Science. Their objective was to identify any published materials from the period of 2014 to 2024 available in each database. To accomplish this, they devised an all-encompassing search strategy utilizing MeSH keywords. Within the realm of their study, they utilized the phrases "Safety and Efficacy", "Mini-Gastric Bypass Surgery", "Clinical trials", and "observational" to further enrich their investigation. Results: 156 articles were collected, nine full-text studies included in the review. The included studies provide insights into the safety and efficacy of MGB surgery. Studies from different countries report positive outcomes related to resolution of comorbidities and weight loss. Conclusion: MGB surgery is a promising alternative for those considering bariatric surgery. More research and follow-up studies are necessary for concerns and standard of care establishment.