Sleeve Gastrectomy Provides a Better Control of Diabetes by Decreasing Ghrelin in the Diabetic Goto–Kakizaki Rats

Li, Feng; Jiang, Liang; Ding, Xiangjiu; Cheng, Zhiqiang; Hu, Sanyuan

doi:10.1007/s11605-009-0997-1

Cited by 41 publications

(29 citation statements)

References 39 publications

(45 reference statements)

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“…In rodents, Shin et al 35 saw greater suppression of acylated ghrelin, the active form of ghrelin, in response to meal, similar to what has been seen in a T2DM rodent model that underwent the VSG procedure. 36 Similar decreases in postprandial total ghrelin were also seen between RYGB and VSG 1 week and 3 months postoperatively. 23 However, other studies have not shown any changes in fasting or mealinduced total ghrelin levels in RYGB patients, 27,37 but still showed significant decreases in patients with VSG.…”

Section: Changes In Gut Hormonesmentioning

confidence: 59%

Bariatric surgeries: beyond restriction and malabsorption

Sandoval

2011

Int J Obes

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Behavioral and pharmaceutical intervention to treat obesity and its comorbidities typically results in only a 5-10% weight loss. Thus, bariatric surgery is the most effective obesity treatment with some surgeries resulting in 30% sustained weight loss. Although this degree of weight loss has profound metabolic impact, these surgeries seem to have metabolic effects that are independent of weight loss. In support of this is the clinical literature showing rapid resolution of Type 2 diabetes mellitus (T2DM) that occurs before significant weight loss. To gain a complete understanding of the weight loss-independent effects of bariatric surgery, animal models have been developed. These are becoming more widely implemented and allow the use of pairfed or weight-matched sham-operated controls in order to gain mechanistic insights into the mode of action of bariatric surgery. Increases in anorectic gut hormones, such as glucagon-like peptide-1 and peptide YY, or decreases in the orexigenic hormone ghrelin have been seen and are implicated as mediators of weight loss-independent actions of bariatric surgery. Changes in nutrient processing and sensing may also have a mechanistic role that is independent of, or that regulates, gut hormone responses to these surgeries. Ultimately, the hope is that understanding the mechanisms of bariatric surgeries will aid in the development of less invasive surgeries or pharmacological therapies that are more specifically, and perhaps individually, targeted at weight loss and/or resolution of T2DM.

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Section: Changes In Gut Hormonesmentioning

confidence: 59%

Bariatric surgeries: beyond restriction and malabsorption

Sandoval

2011

Int J Obes

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“…Previous studies in experimental rat models of SG have shown a decrease in body weight compared to the respective control group [16][17][18][19][20][21][22][23], although not statistically significant in all cases. SG represents a bariatric surgery procedure that involves the reduction of the total stomach size and lumen through the removal of gastric tissue along the greater curvature of the stomach from the fundus to the antrum.…”

Section: Discussionmentioning

confidence: 78%

“…SG experimental models have been successfully carried out in diverse species, mainly pigs and rats, providing evidence of the effects on weight reduction and comorbidity improvement [12,[14][15][16][17][18][19][20][21][22][23]. The beneficial impact of this restrictive surgical procedure has been shown in physiological circumstances, diet-induced, and genetic obesity as well as in different type 2 diabetes experimental models.…”

Section: Introductionmentioning

confidence: 99%

Sleeve Gastrectomy Induces Weight Loss in Diet-Induced Obese Rats Even if High-Fat Feeding Is Continued

et al. 2010

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“…PYY exerts its action through NPY receptors, decreases gastric motility in response to food ingestion and induces satiety [25][26][27][28]. Further it is documented that PYY shows a close relation to insulin resistance and insulin secretion [29][30].…”

Section: Sleeve Gastrectomy and Its Mode Of Action On Weight Lossmentioning

confidence: 99%

Technique and results of single-step laparoscopic sleeve resection*

et al. 2012

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Background: The epidemic of obesity assumes vast proportions with approximately estimated 2.3 billion overweight adults and more than 700 millions defined as obese according to the World Health Organization in 2015. The close relation between obesity and its co-morbidities such as hypertension, insulin resistance and diabetes mellitus type 2 are well documented. Laparoscopic sleeve gastrectomy (LSG) was initially described as a first-step procedure followed by either biliopancreatic diversion with duodenal switch (BPD-DS) or Roux-en-Y gastric bypass (RYGBP) in super-super obese patients (i.e. BMI>60 kg/m 2 ) or in high-risk patients. On the other hand the role of LSG as a single procedure is yet unclear and controversial.Methods: We report about 83 patients enrolled for LSG as single bariatric procedure and a follow-up period of 12 months or more. Follow-up was performed continuously every 3 months and data regarding weight loss, GERD and subjective well-being as well as blood samples were collected. Mean preoperative BMI was 49 kg/m 2 (range 38-74).Results: Within 12 months patients reached a mean EWL of 63% (31-90%). 22 patients, who suffered preoperatively from diabetes mellitus type 2 showed amelioriation of the disease. Hba1c levels dropped from 6.2% to 5.3%. In 2 (2.4%) cases patients had to be reoperated because of bleeding. 1 (1.2%) patient underwent reoperation because of leakage of the staple line. 13 (15.7%) patients complained about GERD symptoms. Some patients showed occasional symptoms, others could be treated conservatively.Conclusions: Single-step LSG is very well accepted by patients and seems to be efficient regarding weight loss, although large studies concerning long-term results are still rare. In our patients there are some cases of GERD, which seem to ameliorate in the course of time, but objective data are still lacking and further evaluation is necessary.

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Sleeve Gastrectomy Provides a Better Control of Diabetes by Decreasing Ghrelin in the Diabetic Goto–Kakizaki Rats

Abstract: SG shows better control in terms of glucose tolerance and other measurements. This study provides direct evidence that SG possesses better improvement of diabetes by reduction of Ghrelin.

Cited by 41 publications

References 39 publications

Bariatric surgeries: beyond restriction and malabsorption

Bariatric surgeries: beyond restriction and malabsorption

Sleeve Gastrectomy Induces Weight Loss in Diet-Induced Obese Rats Even if High-Fat Feeding Is Continued

Technique and results of single-step laparoscopic sleeve resection*

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