Sleeve Gastrectomy for Obesity in Polycystic Ovarian Syndrome: a Pilot Study Evaluating Weight Loss and Fertility Outcomes

Abstract

Compared to non-PCOS patients, PCOS patients had greater postoperative ΔBMI and %EWL at 1 year. The majority of patients becoming pregnant after VSG were previously nulliparous. This study shows that VSG is effective for weight loss in PCOS patients with obesity and may positively augment effect fertility rates.

The Impact of Sleeve Gastrectomy on Females With Polycystic Ovarian Syndrome From 2018 to 2020 in Riyadh, Saudi Arabia: A Prospective Study

“…Dilday et al investigated the outcomes of sleeve gastrectomy in patients with PCOS related to weight loss and fertility. Through 119 PCOS patients, they demonstrated that most of the PCOS patients became pregnant after the operation, with an effective weight loss and weight control [16].…”

Laparoscopic Sleeve Gastrectomy: Outcomes, Safety and Complications

“…These hormonal changes were also associated with the regulation of the menstrual cycle and resolution of dysmenorrhea [45]. Moreover, 22% percent of PCOS patients became pregnant within 12 months, 69% of which were previously nulliparous [43].…”

“…Polycystic ovarian syndrome (PCOS) is a common endocrine disorder associated with obesity. Women with PCOS have hyperandrogenism and hyperinsulinemia with subsequent insulin resistance and infertility [43]. LSG is effective in treating PCOS, resulting not only in WL, but also significant improvement in the hormonal profile [43,44].…”

“…Women with PCOS have hyperandrogenism and hyperinsulinemia with subsequent insulin resistance and infertility [43]. LSG is effective in treating PCOS, resulting not only in WL, but also significant improvement in the hormonal profile [43,44]. Significant decrease is observed as early as 3 months post-surgery in luteinizing hormone (LH) levels (7.2 vs. 4.5 mIU/mL), with inversion of LH/ FSH ratio (P = 0.008), as well as significant decrease in fasting insulin levels (24.4 mIU/mL vs. 9.0 mIU/mL) [44].…”

“…Significant decrease is observed as early as 3 months post-surgery in luteinizing hormone (LH) levels (7.2 vs. 4.5 mIU/mL), with inversion of LH/ FSH ratio (P = 0.008), as well as significant decrease in fasting insulin levels (24.4 mIU/mL vs. 9.0 mIU/mL) [44]. LSG also positively augments fertility rates [43,45]. A cohort of 53 women had a progressive increase of serum anti-Mullerian hormone (marker of ovarian reserve) levels 6 months after LSG [45].…”