Sleep-wake cycle disturbances and NeuN-altered expression in adult rats after cannabidiol treatments during adolescence

Murillo-Rodrı́guez, Eric; Millán-Aldaco, Diana; Cicconcelli, Dorotea; Giorgetti, Valentina; Arankowsky‐Sandoval, Gloria; Alcaraz-Silva, Jocelyne; Imperatori, Claudio; Machado, Sérgio; Budde, Henning; Torterolo, Pablo

doi:10.1007/s00213-021-05769-z

Cited by 13 publications

(5 citation statements)

References 46 publications

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“…The literature is contradictory with respect to the effect of CBD on sleep in both human and animal studies, as some do not find an effect [22][23][24], some show significant improvements [22][23][24][25][26][27][28][29][30][31], and some show detrimental effects [22,27,[32][33][34]. The data from this study suggest that these differences may be due to the underlying quality of sleep of individuals and the severity of DD.…”

Section: Discussioncontrasting

confidence: 64%

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The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function

Kaufmann¹,

Bozer

Jotte

et al. 2023

Med Cannabis Cannabinoids

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Introduction: Previous research indicated that cannabidiol (CBD) may result in low levels of male total testosterone (TT), elevations in liver tests (LTs), and daytime drowsiness (DD). We investigated the prevalences of TT and LT in a large adult sample self-administering CBD and determined the effect self-dosing of CBD has on the severity of DD. Methods: Adult participants (18–75 years of age) who self-dose CBD orally for a minimum of 30 days were recruited for this decentralized observational study from companies that offer CBD products. Participants were sent their usual CBD regimen. A clinical study platform was used on a phone app to obtain consent and collect study data. Data included demographic information, reasons for self-dosing, dosage, current medications and dosage, medical history, adverse effects, effects on DD, and efficacy. After 30 days, LT and TT were obtained and follow-up LT was offered to participants who demonstrated elevated values of alanine transaminase (ALT). Results: A total of 28,121 individuals were contacted, 1,475 met the criteria and were enrolled, and 1,061 (female: 65.2%, male: 34.8%) completed the study. Most of the participants used full-spectrum CBD oil or CBD isolate with the mean ± SD daily dose of CBD for all users of 55.4 ± 37.8 mg. CBD use was associated with a significant decrease in DD and a decrease in the prevalence of low TT in males >40 years of age. The prevalences of elevations in ALT and aspartate aminotransferase were not significantly different from those of the general adult population, and the prevalences of elevated levels of alkaline phosphatase and bilirubin were less than those of a healthy adult population. There was no relationship between LT and CBD dose. Conclusions: In this large-sample study, self-dosing CBD was not associated with an increased prevalence of elevation of LT or low levels of TT in men. Furthermore, CBD administration decreased DD and was associated with a lower prevalence of low testosterone levels in older men as compared to age-adjusted population norms.

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Section: Discussioncontrasting

confidence: 64%

“…In one study, high-dose CBD use in individuals with epilepsy (10–20 mg/kg) causes drowsiness in 30% of individuals, but a different study found that it improves sleep and reduces DD [22, 27]. In rats, CBD improves sleep and decreases drowsiness during times of wakefulness [30, 31, 34].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function

Kaufmann¹,

Bozer

Jotte

et al. 2023

Med Cannabis Cannabinoids

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“…Studies in rats suggest that there is a correlation between CBD dose and increased percentage of sleep [133][134][135]. Additionally, chronic CBD exposure in adolescent rats leads to a decrease in wakefulness during the dark period [136]. Survey data from people using CBD to promote sleep have been highly variable, and this may be attributed to the high variability in the content and quality of CBD currently on the market [132].…”

Section: Sleepmentioning

confidence: 99%

Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals

2022

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Background: There is a growing interest in the use of cannabis (and its extracts), as well as CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is reason to believe that cannabinoids may be efficacious for a number of different diseases and syndromes, there exist limited objective data supporting the use of crude materials (CBD oil, cannabis extracts, and/or cannabis itself). Summary: In the present review, we examined data for pure cannabinoid compounds (dronabinol, nabilone, and CBD), as well as partially purified medicinal cannabis extracts (nabiximols), to provide guidance on the potential therapeutic uses of high-THC cannabis and CBD oil. In general, data support a role for cannabis/cannabinoids in pain, seizure disorders, appetite stimulation, muscle spasticity, and treatment of nausea/vomiting. Given the biological activities of the cannabinoids, there may be utility in treatment of central nervous system disorders (such as neurodegenerative diseases, PTSD, and addiction) or for the treatment of cancer. However, those data are much less compelling. Key Message: On balance, there are reasons to support the potential use of medical cannabis and cannabis extract (Δ9-THC-dominant or CBD-dominant), but much more careful research is required.

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“…Previous research has shown that roughly 27–42% of CBD users report improvement of sleep as reason for administration [ 43 , 44 ]. Improved sleep quality has been shown mainly in animal models [ 45 , 46 ] and not clearly in humans [ 47 , 48 , 49 ]. Additionally, first studies have shown a small effect on muscle soreness after CBD supplementation [ 50 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

et al. 2021

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Cannabidiol supplements (CBD) are increasingly consumed by athletes to improve regeneration. However, the evidence for the pro-regenerative effects of CBD in sports is quite limited. Therefore, our aim was to investigate the effects of a single CBD supplementation in a six-arm placebo-controlled crossover study after resistance training on performance and muscle damage. Before and after the resistance training, one-repetition maximum in the back squat (1RM BS), countermovement jump (CMJ), and blood serum concentrations of creatine kinase (CK) and myoglobin (Myo) were measured in healthy, well-trained participants. Sixteen of 21 participants completed the study and were included in the analysis. In 1RM BS, a significant decrease was observed after 24 h (p < 0.01) but not 48 or 72 h. A significant group difference was detected after 72 h (p < 0.05; ES = 0.371). In CMJ, no significant changes were observed. The CK and Myo concentrations increased significantly after 24 h (CK: p < 0.001; Myo: p < 0.01), 48 h (CK: p < 0.001; Myo: p < 0.01) and 72 h (CK: p < 0.001; Myo: p < 0.001). After 72 h, a significant group difference was observed in both muscle damage biomarkers (CK: p < 0.05 ES = 0.236; Myo: p < 0.05; ES = 0.214). The results show small and significant effects on muscle damage and recovery of squat performance after 72 h. However, more data are necessary for clearer statements about the pro-regenerative effects of CBD supplementation after resistance training.

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Sleep-wake cycle disturbances and NeuN-altered expression in adult rats after cannabidiol treatments during adolescence

Cited by 13 publications

References 46 publications

The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function

The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function

Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals

Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

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