Sleep, Synaptic Plasticity, and Memory

Golbert, Daiane Cristina Ferreira; Souza, Annie C.; Almeida-Filho, Daniel G.; Ribeiro, Sidarta

doi:10.1016/b978-0-12-809324-5.21118-8

Cited by 1 publication

(2 citation statements)

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“…Similar biases are exhibited by studies using molecular techniques where screenings are often compared between sleep and wake. However, when sleep stages are considered, results indicate a significant influence of REM sleep on gene expression (Golbert et al, 2017). Functional imaging during development and adulthood also revealed that Ca 2+ activity synchronization in the cortex is closely associated with specific sleep rhythms, such as spindle-like oscillations.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Experimental evidence in humans and animals suggests that sleep plays a central role in brain development, cognition and plasticity (Golbert et al, 2017; Puentes-Mestril and Aton, 2017; Tononi and Cirelli, 2014). Sleep is involved in physiological processes in the brain and periphery, such as temperature and hormone regulation, neuromodulation, brain activity, and gene expression.…”

Section: Introductionmentioning

confidence: 99%

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Peeking into the sleeping brain: Using in vivo imaging in rodents to understand the relationship between sleep and cognition

Sigl‐Glöckner

Seibt

2019

Journal of Neuroscience Methods

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Sleep is well known to benefit cognitive function. In particular, sleep has been shown to enhance learning and memory in both humans and animals. While the underlying mechanisms are not fully understood, it has been suggested that brain activity during sleep modulates neuronal communication through synaptic plasticity. These insights were mostly gained using electrophysiology to monitor ongoing large scale and single cell activity. While these efforts were instrumental in the characterisation of important network and cellular activity during sleep, several aspects underlying cognition are beyond the reach of this technology. Neuronal circuit activity is dynamically regulated via the precise interaction of different neuronal and non-neuronal cell types and relies on subtle modifications of individual synapses. In contrast to established electrophysiological approaches, recent advances in imaging techniques, mainly applied in rodents, provide unprecedented access to these aspects of neuronal function in vivo. In this review, we describe various techniques currently available for in vivo brain imaging, from single synapse to large scale network activity. We discuss the advantages and limitations of these approaches in the context of sleep research and describe which particular aspects related to cognition lend themselves to this kind of investigation. Finally, we review the few studies that used in vivo imaging in rodents to investigate the sleeping brain and discuss how the results have already significantly contributed to a better understanding on the complex relation between sleep and plasticity across development and adulthood.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%