Sleep Symptoms During the Menopausal Transition and Early Postmenopause: Observations from the Seattle Midlife Women's Health Study

Woods, Nancy Fúgate; Mitchell, Ellen Sullivan

doi:10.1093/sleep/33.4.539

Cited by 170 publications

(151 citation statements)

References 36 publications

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“…A structured online questionnaire that included a range of validated instruments and items was used to collect data on: (1) socio-demographic characteristics; (2) modifiable lifestyle risk factors including exercise and physical activity (Seattle Physical Activity questionnaire) [16], smoking and alcohol consumption [17], fruit and vegetable consumption [18] and self-reported height and weight from which BMI was calculated [19]; (3) physical and mental functional health and well-being (MOS SF-12v2) [20]; (4) exercise self-efficacy [21], and; perceived exercise benefits and barriers [22]. The exercise benefits and barriers scale (EBBS) is a 46 item instrument using a forced response Likert type scale with four response categories (Strongly agree, Agree, Disagree, Strongly disagree).…”

Section: Methodsmentioning

confidence: 99%

Factors predicting barriers to exercise in midlife Australian women

2016

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On average, the 225 participants were aged 50.9 years (SD=5.9). The significant predictors of perceived barriers to exercise were perceived benefits of exercise, exercise self-efficacy, physical well-being and mental well-being. These variables explained 41% of the variance in the final model (F (8219)=20.1, p<.01) CONCLUSIONS: In midlife women, perceptions of barriers to exercise correlate with beliefs about the health benefits of exercise, exercise self-efficacy, physical and mental well-being. These findings have application to health promotion interventions targeting exercise behaviour change in midlife women.

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Section: Methodsmentioning

confidence: 99%

Factors predicting barriers to exercise in midlife Australian women

2016

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“…The extent to which sleep is disturbed during menopause may depend on the severity of menopausal symptoms. Hot flushes affect 75-85% of women across the menopausal transition and are associated with sleep disruption [96,100,103,104]. Nevertheless, the exact relationship between hot flushes and sleep disruption remains controversial.…”

Section: (C) Sex Steroids Influence Sleepmentioning

confidence: 99%

Sex differences in sleep: impact of biological sex and sex steroids

Mong

Cusmano

2016

Phil. Trans. R. Soc. B

367

300

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One contribution of 16 to a theme issue 'Multifaceted origins of sex differences in the brain'. Men and women sleep differently. While much is known about the mechanisms that drive sleep, the reason for these sex differences in sleep behaviour is unknown and understudied. Historically, women and female animals are underrepresented in studies of sleep and its disorders. Nevertheless, there is a growing recognition of sex disparities in sleep and rhythm disorders. Women typically report poorer quality and more disrupted sleep across various stages of life. Findings from clinical and basic research studies strongly implicate a role for sex steroids in sleep modulation. Understanding how neuroendocrine mediators and sex differences influence sleep is central to advancing our understanding of sleep-related disorders. The investigation into sex differences and sex steroid modulation of sleep is in its infancy. Identifying the mechanisms underlying sex and gender differences in sleep will provide valuable insights leading to tailored therapeutics that benefit each sex. The goal of this review is to discuss our current understanding of how biological sex and sex steroids influence sleep behaviour from both the clinical and pre-clinical perspective.

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“…Many studies have endorsed the relationship between perceived vasomotor symptoms and perceived sleep disturbances. 4,42,43 However, the results in objective sleep studies have been inconsistent, depending on subjective or objective measurements of vasomotor symptoms. 44 In a study of Young et al, sleep variables did not differ in menopausal women, whether or not the women reported hot flashes.…”

Section: Effect Of Time Effect Of S-fshmentioning

confidence: 99%

“…1 This has been confirmed in several large longitudinal studies. [2][3][4] However, the evidence for changes in sleep architecture during menopausal transition is inconsistent. 5,6 There are only a few polysomnographic (PSG) sleep studies assessing sleep architecture in premenopausal and postmenopausal women, all with cross-sectional design.…”

Section: Introductionmentioning

confidence: 99%

“…13 Poor sleep is reported especially in the presence of vasomotor symptoms. 2,4,14,15 Nevertheless, even today the researchers are not unanimous about the primary cause of menopausal sleep disturbance. In addition to fluctuations and decrease in reproductive hormone concentrations, aging itself, 16 depressive symptoms, 17,18 sleep-disordered breathing, primary sleep disorders, other systemic diseases and/ or their medications as well as psychosocial or behavioral factors may contribute to sleep impairment.…”

Section: Introductionmentioning

confidence: 99%

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Sleep During Menopausal Transition: A 6-Year Follow-Up

Lampio¹,

Polo‐Kantola²,

Himanen³

et al. 2017

Sleep

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Study Objectives: Menopausal transition is associated with increased dissatisfaction with sleep, but the effects on sleep architecture are conflicting. This prospective 6-year follow-up study was designed to evaluate the changes in sleep stages and sleep continuity that occur in women during menopausal transition. Methods: Sixty women (mean age 46.0 years, SD 0.9) participated. All women were premenopausal at baseline, and at the 6-year follow-up, women were in different stages of menopausal transition. Polysomnography was used to study sleep architecture at baseline and follow-up. The effects of aging and menopause (assessed as change in serum follicle-stimulating hormone [S-FSH]) on sleep architecture were evaluated using linear regression models. Results: After controlling for body mass index, vasomotor, and depressive symptoms, aging of 6 years resulted in shorter total sleep time (B −37.4, 95% confidence interval [CI] −71.5 to (−3.3)), lower sleep efficiency (B −6.5, 95%CI −12.7 to (−0.2)), as well as in increased transitions from slow-wave sleep (SWS) to wakefulness (B 1.0, 95%CI 0.1 to 1.9), wake after sleep onset (B 37.7, 95%CI 12.5 to 63.0), awakenings per hour (B 1.8, 95%CI 0.8 to 2.8), and arousal index (B 2.3, 95%CI 0.1 to 4.4). Higher S-FSH concentration in menopausal transition was associated with increased SWS (B 0.09, 95%CI 0.01 to 0.16) after controlling for confounding factors. Conclusions: A significant deterioration in sleep continuity occurs when women age from 46 to 52 years, but change from premenopausal to menopausal state restores some SWS.

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Sleep Symptoms During the Menopausal Transition and Early Postmenopause: Observations from the Seattle Midlife Women's Health Study

Abstract: Sleep symptoms during the MT may be amenable to symptom management strategies that take into account the symptom clusters and promote women's general health rather than focusing only on the MT.

Cited by 170 publications

References 36 publications

Factors predicting barriers to exercise in midlife Australian women

Factors predicting barriers to exercise in midlife Australian women

Sex differences in sleep: impact of biological sex and sex steroids

Sleep During Menopausal Transition: A 6-Year Follow-Up

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