Sleep State Switching

Saper, Clifford B.; Fuller, Patrick M.; Pedersen, Nigel P.; Lü, Jun; Scammell, Thomas E.

doi:10.1016/j.neuron.2010.11.032

Cited by 1,186 publications

(1,143 citation statements)

References 223 publications

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“…The neural circuitry and mechanisms underlying sleep and wakefulness have been extensively studied (for review see [6]). However, studies investigating (i) whether sex differences exist and (ii) the precise targets of oestradiol action within these circuits are in their infancy.…”

Section: (B) Sexual Differentiation Of Sleep Circuitrymentioning

confidence: 99%

Sex differences in sleep: impact of biological sex and sex steroids

Mong

Cusmano

2016

Phil. Trans. R. Soc. B

400

300

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One contribution of 16 to a theme issue 'Multifaceted origins of sex differences in the brain'. Men and women sleep differently. While much is known about the mechanisms that drive sleep, the reason for these sex differences in sleep behaviour is unknown and understudied. Historically, women and female animals are underrepresented in studies of sleep and its disorders. Nevertheless, there is a growing recognition of sex disparities in sleep and rhythm disorders. Women typically report poorer quality and more disrupted sleep across various stages of life. Findings from clinical and basic research studies strongly implicate a role for sex steroids in sleep modulation. Understanding how neuroendocrine mediators and sex differences influence sleep is central to advancing our understanding of sleep-related disorders. The investigation into sex differences and sex steroid modulation of sleep is in its infancy. Identifying the mechanisms underlying sex and gender differences in sleep will provide valuable insights leading to tailored therapeutics that benefit each sex. The goal of this review is to discuss our current understanding of how biological sex and sex steroids influence sleep behaviour from both the clinical and pre-clinical perspective.

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Section: (B) Sexual Differentiation Of Sleep Circuitrymentioning

confidence: 99%

Sex differences in sleep: impact of biological sex and sex steroids

Mong

Cusmano

2016

Phil. Trans. R. Soc. B

400

300

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“…The neurotransmitter or neuropeptide-like choline or orexin neurons found in the sleep-wake regulating nuclei (such as pedunculopontine tegmetal nucleus and lateral hypothalamus) [36] may project to the ventral tegmental area, one of the key rewarding systems in the brain, to relegate neural activity [37,38] . We found that sucrose preference (measured using a reward-based test for the interest in a sweet solution) [20] was correlated with sleep generation (light sleep bouts and total sleep time) and the REM sleep ratio, suggesting that the altered sleep time may reflect changes in the reward system.…”

Section: Wwwchinapharcom Wang Zj Et Almentioning

confidence: 99%

Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats

Wang

Zhang

et al. 2014

Acta Pharmacol Sin

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Aim: Disrupted sleep may be a prodromal symptom or a predictor of depressive disorders. In this study we investigated the relationship between depression symptoms and disrupted sleep using a novel model of stress-mimicked sleep disorders in rats. Methods: SD rats were injected with corticosterone (10, 20 or 40 mg/kg, sc) or vehicle for 7 d. Their sleep-wake behavior was monitored through implanted EEG and EMG electrodes. Their depressive behaviors were assessed using forced swim test, open field test and sucrose preference test. Results: The corticosterone-treated rats showed significantly reduced sleep time, disinhibition of rapid-eye-movement (REM) sleep and altered power spectra during non-REM sleep. All depressive behavioral tests did not show significant difference across the groups. However, individual correlation analysis revealed statistically significance: the immobility time (despair) was negatively correlated with REM sleep latency, slow wave sleep (SWS) time ratio, SWS bouts and delta power density, and it was positively correlated with REM sleep bouts and beta power density. Meanwhile, sucrose preference (anhedonia) was positively correlated with total sleep time and light sleep bouts, and it was negatively correlated with the REM sleep time ratio. Conclusion: In stress-mimicked rats, sleep disturbances are a predictor of depressive disorders, and certain symptoms of depression may be related to the disruption of several specific sleep parameters.

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“…Sleep is strongly regulated by groups of neurons located in the brainstem and midbrain areas, which form reciprocal connections (Luppi et al, 2011;Saper et al, 2010Saper et al, , 2001Schwartz and Roth, 2008). These ''sleep-wake switches'' are mutually dependent and have been referred to as the wake-sleep and REM-NREM sleep switches, respectively.…”

Section: Introductionmentioning

confidence: 99%