Sleep-Stage Dynamics in Patients with Chronic Fatigue Syndrome with or without Fibromyalgia

Kishi, Akifumi; Natelson, Benjamin H.; Togo, Fumiharu; Struzik, Zbigniew R.; Rapoport, David M.; Yamamoto, Yoshiharu

doi:10.5665/sleep.1396

Cited by 36 publications

(32 citation statements)

References 37 publications

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“…Continuity of sleep was assessed as duration of sleep runs, defined as the duration of consecutive 30-second epochs of sleep scored as that stage, terminated by one or more epochs scored as another stage, including wake (Kishi et al, 2011; Norman et al, 2006). …”

Section: Methodsmentioning

confidence: 99%

Effects of aging on slow-wave sleep dynamics and human spatial navigational memory consolidation

Varga

Ducca

Kishi

et al. 2016

Neurobiology of Aging

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The consolidation of spatial navigational memory during sleep is supported by electrophysiological and behavioral evidence. The features of sleep that mediate this ability may change with aging, as percentage of slow wave sleep is canonically thought to decrease with age, and slow waves are thought to help orchestrate hippocampal-neocortical dialogue that supports systems level consolidation. In this study, groups of younger and older subjects performed timed trials before and after polysomnographically recorded sleep on a 3D spatial maze navigational task. Although younger subjects performed better than older subjects at baseline, both groups showed similar improvement across pre-sleep trials. However, younger subjects experienced significant improvement in maze performance during sleep that was not observed in older subjects, without differences in morning psychomotor vigilance between groups. Older subjects had sleep quality marked by decreased amount of slow wave sleep and increased fragmentation of slow wave sleep, resulting in decreased slow wave activity. Across all subjects, frontal slow wave activity was positively correlated with both overnight change in maze performance and medial prefrontal cortical volume, illuminating a potential neuroanatomical substrate for slow wave activity changes with aging and underscoring the importance of slow wave activity in sleep-dependent spatial navigational memory consolidation.

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Section: Methodsmentioning

confidence: 99%

Effects of aging on slow-wave sleep dynamics and human spatial navigational memory consolidation

Varga

Ducca

Kishi

et al. 2016

Neurobiology of Aging

Self Cite

View full text Add to dashboard Cite

show abstract

“…Continuity of sleep was assessed as duration of sleep runs, defined as the duration of consecutive 30 s epochs of sleep scored as that stage, terminated by one or more epochs scored as another stage, including wake (Norman et al, 2006;Kishi et al, 2011).…”

Section: Methodsmentioning

confidence: 99%

Apnea-Induced Rapid Eye Movement Sleep Disruption Impairs Human Spatial Navigational Memory

et al. 2014

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Hippocampal electrophysiology and behavioral evidence support a role for sleep in spatial navigational memory, but the role of particular sleep stages is less clear. Although rodent models suggest the importance of rapid eye movement (REM) sleep in spatial navigational memory, a similar role for REM sleep has never been examined in humans. We recruited subjects with severe obstructive sleep apnea (OSA) who were well treated and adherent with continuous positive airway pressure (CPAP). Restricting CPAP withdrawal to REM through real-time monitoring of the polysomnogram provides a novel way of addressing the role of REM sleep in spatial navigational memory with a physiologically relevant stimulus. Individuals spent two different nights in the laboratory, during which subjects performed timed trials before and after sleep on one of two unique 3D spatial mazes. One night of sleep was normally consolidated with use of therapeutic CPAP throughout, whereas on the other night, CPAP was reduced only in REM sleep, allowing REM OSA to recur. REM disruption via this method caused REM sleep reduction and significantly fragmented any remaining REM sleep without affecting total sleep time, sleep efficiency, or slow-wave sleep. We observed improvements in maze performance after a night of normal sleep that were significantly attenuated after a night of REM disruption without changes in psychomotor vigilance. Furthermore, the improvement in maze completion time significantly positively correlated with the mean REM run duration across both sleep conditions. In conclusion, we demonstrate a novel role for REM sleep in human memory formation and highlight a significant cognitive consequence of OSA.

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“…[44] Alteration in the transition pattern of sleep stages in CFS has also been observed; in particular, significantly fewer transitions have been found from REM to non-REM sleep over the night in CFS patients in comparison to controls. [41,56] In addition, one study has explored cyclic alternating pattern (CAP) rates in patients with CFS, observing higher values in patients compared to controls. [40] CAP rates are an objective index of sleep instability, typically associated with greater arousability and feelings of unrefreshing sleep.…”

Section: Polysomnography (Psg) Studiesmentioning

confidence: 98%

The role of sleep in chronic fatigue syndrome: a narrative review

Gotts

Ellis

Newton

et al. 2014

Fatigue: Biomedicine, Health & Behavior

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Background: Chronic Fatigue Syndrome (CFS) affects 0.23-2.6% of the adult population. Sleep-related complaints are amongst the most frequently reported symptoms in these patients. Although a biopsychosocial model of CFS offers a plausible framework for understanding the condition, the role of sleep and how it functions within this model remains unclear. Purpose: This narrative review describes the findings of studies of sleep in CFS and considers the reasons behind the diversity of results. The review also discusses the difficulties that exist in establishing relationships between sleep, behaviour, cognition, physiology, and the physical symptoms of CFS. Methods: A search of Medline for the terms "CFS," "chronic fatigue syndrome," AND "sleep" was performed to identify articles concerning sleep and CFS from 1988 to the present. Results: Subjective sleep dysfunction was frequently reported in the CFS sleep studies. However, objective sleep research in CFS has shown no consistent picture of sleep disturbance, particularly with regard to polysomnography. This may be attributable to the heterogeneity of sleep phenotypes in the CFS population as well as the variability in sleep assessment protocols, case definitions, and exclusion criteria used across studies. Conclusions: Given the high prevalence of disturbed sleep in this population in combination with inconsistent findings, exploration of new protocols for the objective assessment of sleep in CFS (e.g., three-night PSG protocol) is recommended. Understanding the distinct sleep characteristics in this population could serve to improve insight into perpetuating factors of CFS symptoms which is relevant for diagnosis and therapy.

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Sleep-Stage Dynamics in Patients with Chronic Fatigue Syndrome with or without Fibromyalgia

Abstract: These results suggest that CFS and FM may be different illnesses associated with different problems of sleep regulation.

Cited by 36 publications

References 37 publications

Effects of aging on slow-wave sleep dynamics and human spatial navigational memory consolidation

Effects of aging on slow-wave sleep dynamics and human spatial navigational memory consolidation

Apnea-Induced Rapid Eye Movement Sleep Disruption Impairs Human Spatial Navigational Memory

The role of sleep in chronic fatigue syndrome: a narrative review

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