Sleep restriction increases blood neutrophils, total cholesterol and low density lipoprotein cholesterol in postmenopausal women: A preliminary study

Kerkhofs, Myriam; Boudjeltia, Karim Zouaoui; Stenuit, Patricia; Brohée, Dany; Cauchie, Philippe; Vanhaeverbeek, Michel

doi:10.1016/j.maturitas.2006.07.007

Cited by 68 publications

(50 citation statements)

References 6 publications

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“…39). This outcome has since been repeatedly demonstrated (13,30,38,44), and it is one of the few consistent physiological findings in humans. In the clinical setting, mild leukocytosis usually would be taken as a sign of underlying infectious disease or inflammatory processes.…”

supporting

confidence: 53%

Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery

Everson¹,

Thalacker²,

Hogg³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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supporting

confidence: 53%

Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery

Everson¹,

Thalacker²,

Hogg³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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“…In agreement with our results, other studies have shown that circulating levels of WBCs, particularly neutrophils, are elevated during SD. 8,11,[27][28][29] In contrast, other studies 3,30,31 did not find such changes. Similar to our findings, Dinges et al 11 reported that the number of WBCs returned to baseline values after 24 h of sleep recovery.…”

Section: Discussionmentioning

confidence: 93%

Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers

et al. 2010

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We investigated the impact of two nights of total sleep deprivation (SD) or four nights of rapid eye movement (REM) SD on immunological parameters in healthy men. Thirty-two volunteers were randomly assigned to three protocols (control, total SD or REM SD). Both SD protocols were followed by three nights of sleep recovery. The control and REM SD groups had regular nights of sleep monitored by polysomnography. Circulating white blood cells (WBCs), T- (CD4/CD8) and B-lymphocytes, Ig classes, complement and cytokine levels were assessed daily. Two nights of total SD increased the numbers of leukocytes and neutrophils compared with baseline levels, and these levels returned to baseline after 24 h of sleep recovery. The CD4(+) T-cells increased during the total SD period (one and two nights) and IgA levels decreased during the entire period of REM SD. These levels did not return to baseline after three nights of sleep recovery. Levels of monocytes, eosinophils, basophils and cytokines (IL-1β, IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ) remained unchanged by both protocols of SD. Our findings suggest that both protocols affected the human immune profile, although in different parameters, and that CD4(+) T-cells and IgA levels were not re-established after sleep recovery.

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“…Experimental sleep restriction has been shown to increase appetite [23], compromise insulin sensitivity [24], raise blood pressure [25], and increase total and low-density lipoprotein (LDL) cholesterol levels [26]. Short sleep duration [27], snoring [28], and shift work [29] have also been found to increase the risk of the metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Daytime sleepiness and risk of coronary heart disease and stroke: results from the Nurses’ Health Study II

et al. 2014

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Objective The objective of this study was to determine whether daytime sleepiness is independently associated with coronary heart disease (CHD) and stroke or whether the positive association is explained by short sleep duration, disturbed sleep, and circadian disruption, conditions that are associated with cardiometabolic risk factors for vascular events. Methods Longitudinal analyses of data from the Nurses’ Health Study II comprising 84,003 female registered nurses aged 37–54 at baseline were conducted in 2001 with follow-up until 2009. Multivariate Cox regression was used to explore the relationship between reported daytime sleepiness and the incidence of either CHD or stroke (n = 500 cases). Results Women who reported daytime sleepiness almost every day, compared with rarely/never, had an elevated adjusted risk of cardiovascular disease (CVD) (hazard ratio (HR) = 1.58, 95% confidence interval (CI) 1.15–2.17). Controlling for sleep variables (sleep duration, snoring, shift work, and sleep adequacy) or potential metabolic biological mediators of disrupted sleep (diabetes, hypercholesterolemia, and hyper-tension) appreciably attenuated the relationship (HR = 1.17, 95% CI 0.84–1.65; and HR = 1.34, 95% CI 0.97–1.85, respectively). Controlling for both sleep variables and metabolic risk factors eliminated an independent association (HR = 1.09, 95% CI 0.77–1.53). A similar pattern was observed for CHD and stroke individually. Conclusions Daytime sleepiness was not an independent risk factor for CVD in this cohort of women, but rather, was associated with sleep characteristics and metabolic abnormalities that are risk factors for CVD.

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Sleep restriction increases blood neutrophils, total cholesterol and low density lipoprotein cholesterol in postmenopausal women: A preliminary study

Cited by 68 publications

References 6 publications

Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery

Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery

Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers

Daytime sleepiness and risk of coronary heart disease and stroke: results from the Nurses’ Health Study II

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