Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease

Comella, Cynthia L.; Nardine, T. M.; Diederich, Nico J.; Stebbins, Glenn T.

doi:10.1212/wnl.51.2.526

Cited by 350 publications

(172 citation statements)

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“…As a matter of fact, this questionnaire has never been validated in PD patients. The frequency of RBD in PD, as diagnosed by questionnaires, is different from video-polysomnographically diagnosed RBD (its frequency ranges from 33-47%), demonstrating the difficulty to predict RBD clinically [14,28,29]. It should be noted, however, that in a recent Japanese study, 54% of PD patients studied were diagnosed with RBD, based on questionnaire data [30].…”

Section: Sleepwalking and Parkinson's Disease: Prevalencementioning

confidence: 85%

“…In questionnaire-based studies asking for sleepwalking/nighttime wandering in PD patients, frequencies ranging from 2% (4/201) [13], 3% (2/61, resp. 2/66) [9,14] to 5% (16/303) [15] can be found in the literature, however, no detailed characteristics of the phenomenon were studied. The aim of the present study was to assess frequency and characteristics of SW/nighttime wandering in patients with PD.…”

Section: Introductionmentioning

confidence: 99%

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Sleepwalking in Parkinson’s disease: a questionnaire-based survey

Oberholzer

Poryazova

2011

J Neurol

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Sleepwalking (SW) corresponds to a complex sleep-associated behavior that includes locomotion, mental confusion, and amnesia. SW is present in about 10% of children and 2-3% of adults. In a retrospective series of 165 patients with Parkinson's disease (PD), we found adult-onset (''de novo'') SW ''de novo'' in six (4%) of them. The aim of this study was to assess prospectively and systematically the frequency and characteristics of SW in PD patients. A questionnaire including items on sleep quality, sleep disorders, and specifically also SW and REM sleep behavior disorder (RBD), PD characteristics and severity, was sent to the members of the national PD patients organization in Switzerland. In the study, 36/417 patients (9%) reported SW, of which 22 (5%) had adultonset SW. Patients with SW had significantly longer disease duration (p = 0.035), they reported more often hallucinations (p = 0.004) and nightmares (p = 0.003), and they had higher scores, suggestive for RBD in a validated questionnaire (p = 0.001). Patients with SW were also sleepier (trend to a higher Epworth Sleepiness Scale score, p = 0.055). Our data suggest that SW in PD patients is (1) more common than in the general population, and (2) is associated with RBD, nightmares, and hallucinations. Further studies including polysomnographic recordings are needed to confirm the results of this questionnaire-based analysis, to understand the relationship between SW and other nighttime wandering behaviors in PD, and to clarify the underlying mechanisms.

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Section: Sleepwalking and Parkinson's Disease: Prevalencementioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Sleepwalking in Parkinson’s disease: a questionnaire-based survey

Oberholzer

Poryazova

2011

J Neurol

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“…There is a high occurrence of RBD in patients with PD, up to 60% in some studies [57,58], and up to 80% in DLB patients [59] [60][61][62], with Postuma et al [61] also finding deficits in color discrimination compared with a control population. Using questionnaires, they also found autonomic dysfunction with abnormalities in constipation, erectile dysfunction, and urinary scores [61].…”

Section: While Sleep Disorders Worsen As Pd Advances It Is Clear Thamentioning

confidence: 97%

Premotor Symptoms and Early Diagnosis of Parkinson's Disease

Adler

2011

International Journal of Neuroscience

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“…2 Most patients report vivid, frightening dreams, leading to violent behavior, often resulting in injuries of patients or their bed partners. 3 The prevalence of RBD reported in the general population is < 1%, 4,5 whereas in neurodegenerative disorders, especially synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), a much higher frequency is found. 6,7 It has been shown that PSG is the gold standard for the diagnosis of RBD, since only half of the patients are detected by history.…”

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

REM Sleep Behavior Disorder in Parkinson's Disease: A Questionnaire-Based Survey

Poryazova

Oberholzer

Baumann

et al. 2013

Journal of Clinical Sleep Medicine

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bRIEF SUMMaRYCurrent Knowledge/Study Rationale: RBD is very common in PD and there have been multiple attempts to fi nd a questionnaire based diagnostic tool for RBD. For the fi rst time we use a previously validated questionnaire tool assessment of RBD in a large, unselected sample of PD patients. Study Impact: RBD in PD could be detected by a validated questionnaire tool in 42.6% of the patients, which is comparable to the frequency found in PSG-based studies. It was associated with more advanced disease, sleep fragmentation and hallucinations.

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Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease

Abstract: PD patients with SRI frequently have behavioral features of RBD. If RBD underlies most SRI, treatment with appropriate pharmacologic agents, such as clonazepam, may prevent future occurrences of SRI.

Cited by 350 publications

References 8 publications

Sleepwalking in Parkinson’s disease: a questionnaire-based survey

Sleepwalking in Parkinson’s disease: a questionnaire-based survey

Premotor Symptoms and Early Diagnosis of Parkinson's Disease

REM Sleep Behavior Disorder in Parkinson's Disease: A Questionnaire-Based Survey

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